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Study · Measured the body's own peptide · 2018

3 results

Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia.

Rubin LH, Li S, Yao L, Keedy SK, Reilly JL, Hill SK, Bishop JR, Sue Carter C, Pournajafi-Nazarloo H, Drogos LL, Gershon E, Pearlson GD and 5 more

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Tamminga CA, Clementz BA, Keshavan MS, Lui S, Sweeney JA

Schizophrenia research6 Jul 2018Cited by 19 (Europe PMC)

PMID30539769 (opens in a new tab)PMCIDPMC6293995 (opens in a new tab)DOI10.1016/j.schres.2018.07.003 (opens in a new tab)PepBankPUB-30539769
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In women with schizophrenia, lower serum oxytocin levels were associated with lower resting brain activity (ALFF) in frontal and cerebellar cortices.

    In plain wordsIn women with schizophrenia, lower levels of the body's own oxytocin were linked to lower resting activity in frontal and cerebellar brain areas.

    Peptide
    Oxytocin
    Outcome
    Not applicableSerum oxytocin and ALFF in female patients with schizophrenia
    Study

    n: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition

    Source sentences

    Summary
    In female patients, lower OT levels were associated with lower ALFF in frontal and cerebellar cortices (p's < 0.05)
    2 context sentences
    Summary · context
    OT and AVP serum concentrations were assayed in 35 individuals with schizophrenia (23 men) and 60 controls (24 men) from the Chicago BSNIP study site.
    Summary · context
    Regional cerebral function was assessed with resting state fMRI by measuring the amplitude of low-frequency fluctuations (ALFF) which are believed to reflect intrinsic spontaneous neuronal activity.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In men with schizophrenia, lower serum oxytocin levels were associated with lower resting brain activity (ALFF) in the posterior cingulate.

    In plain wordsIn men with schizophrenia, lower levels of the body's own oxytocin were linked to lower resting activity in the posterior cingulate brain area.

    Peptide
    Oxytocin
    Outcome
    Not applicableSerum oxytocin and ALFF in male patients with schizophrenia
    Study

    n: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition

    Source sentences

    Summary
    In male patients, lower OT levels were associated with lower ALFF in the posterior cingulate
    2 context sentences
    Summary · context
    OT and AVP serum concentrations were assayed in 35 individuals with schizophrenia (23 men) and 60 controls (24 men) from the Chicago BSNIP study site.
    Summary · context
    Regional cerebral function was assessed with resting state fMRI by measuring the amplitude of low-frequency fluctuations (ALFF) which are believed to reflect intrinsic spontaneous neuronal activity.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In healthy men, lower serum oxytocin levels were associated with lower resting brain activity (ALFF) in frontal cortex and higher activity in the thalamus.

    In plain wordsIn healthy men, lower levels of the body's own oxytocin were linked to lower frontal and higher thalamic resting brain activity.

    Peptide
    Oxytocin
    Outcome
    MixedSerum oxytocin and ALFF in male controls
    Study

    n: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition

    Source sentences

    Summary
    In male controls, lower OT levels were associated with lower ALFF in frontal cortex and higher ALFF in the thalamus (p's < 0.05).
    2 context sentences
    Summary · context
    OT and AVP serum concentrations were assayed in 35 individuals with schizophrenia (23 men) and 60 controls (24 men) from the Chicago BSNIP study site.
    Summary · context
    Regional cerebral function was assessed with resting state fMRI by measuring the amplitude of low-frequency fluctuations (ALFF) which are believed to reflect intrinsic spontaneous neuronal activity.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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