Oxytocin Modulates the Intrinsic Dynamics Between Attention-Related Large-Scale Networks.

Xin F, Zhou F, Zhou X, Ma X, Geng Y, Zhao W, Yao S, Dong D, Biswal BB, Kendrick KM, Becker B

Cerebral cortex (New York, N.Y. : 1991)1 Feb 2021Cited by 41 (Europe PMC)

PMID30535355DOI10.1093/cercor/bhy295PepBankPUB-30535355

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanRandomized controlled trialMechanism
In healthy adults, single-dose intranasal oxytocin increased functional integration between subsystems within the salience and default networks versus placebo.
In plain wordsIn healthy adults, one dose of oxytocin increased how closely parts of two brain attention networks worked together, compared with placebo.
Peptide
Oxytocin
Outcome
IncreaseFunctional integration between subsystems within salience and default networks
Study
n = 187
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · single doseAs given in this study (human).
Source sentences
Summary
OXT increased the functional integration between subsystems within SN and DN
1 context sentence(design, population, supporting numbers)
Summary · context
The current randomized placebo (PLC)-controlled between-subject pharmacological resting-state fMRI study in N = 187 (OXT, n = 94; PLC, n = 93; single-dose intranasal administration) healthy male and female participants employed an independent component analysis approach to determine the modulatory e…
Report a problemFND-3053535501
02HumanRandomized controlled trialMechanism
In healthy adults, single-dose intranasal oxytocin increased functional segregation of the default network from the salience and dorsal attention networks versus placebo.
In plain wordsIn healthy adults, one dose of oxytocin made the brain's default network more separate from attention networks, compared with placebo.
Peptide
Oxytocin
Outcome
IncreaseFunctional segregation of default network from attentional control networks
Study
n = 187
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · single doseAs given in this study (human).
Source sentences
Summary
increased functional segregation of the DN with both attentional control networks (SN and DAN).
1 context sentence(design, population, supporting numbers)
Summary · context
The current randomized placebo (PLC)-controlled between-subject pharmacological resting-state fMRI study in N = 187 (OXT, n = 94; PLC, n = 93; single-dose intranasal administration) healthy male and female participants employed an independent component analysis approach to determine the modulatory e…
Report a problemFND-3053535502
03HumanRandomized controlled trialMechanism
In healthy adults, no sex differences were observed in the effects of intranasal oxytocin on the triple network dynamics.
In plain wordsIn healthy adults, oxytocin's effects on brain networks did not differ between men and women.
Peptide
Oxytocin
Outcome
No significant changeSex differences in oxytocin effects
Study
n = 187
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · single doseAs given in this study (human).
Source sentences
Summary
Whereas no sex differences were observed
1 context sentence(design, population, supporting numbers)
Summary · context
The current randomized placebo (PLC)-controlled between-subject pharmacological resting-state fMRI study in N = 187 (OXT, n = 94; PLC, n = 93; single-dose intranasal administration) healthy male and female participants employed an independent component analysis approach to determine the modulatory e…
Report a problemFND-3053535503
04HumanRandomized controlled trialMechanism
In healthy adults, oxytocin effects on the default network and salience network interaction were modulated by autistic traits.
In plain wordsIn healthy adults, how oxytocin affected two brain networks depended on the person's level of autistic traits.
Peptide
Oxytocin
Outcome
Not applicableModulation of default-salience network effects by autistic traits
Study
n = 187
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · single doseAs given in this study (human).
Source sentences
Summary
OXT effects on the DN-SN interaction were modulated by autistic traits
1 context sentence(design, population, supporting numbers)
Summary · context
The current randomized placebo (PLC)-controlled between-subject pharmacological resting-state fMRI study in N = 187 (OXT, n = 94; PLC, n = 93; single-dose intranasal administration) healthy male and female participants employed an independent component analysis approach to determine the modulatory e…
Report a problemFND-3053535504

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 1
9 Oct 2026, 02:49 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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