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Study · Animal study (in vivo) · mouse · 2018

4 results

Cerebrolysin increases motor recovery and decreases inflammation in a mouse model of autoimmune encephalitis.

Toader LE, Roşu GC, Cătălin B, Pirici I, Gîlceavă IC, Albu VC, Istrate-Ofiţeru AM, Mureşanu DF, Pirici D

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie1 Jan 2018Cited by 5 (Europe PMC)

PMID30534814 (opens in a new tab)PepBankPUB-30534814
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with autoimmune encephalitis, Cerebrolysin treatment was associated with lower motor deficit scores than no treatment.

    In plain wordsIn mice with autoimmune encephalitis, Cerebrolysin-treated animals had lower motor deficit scores than untreated animals.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseMotor deficit scores
    Study

    mousen = 20

    Experimental autoimmune encephalitis
    Comparator
    Untreated EAE mice
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results showed higher deficit scores for untreated animals compared to treated animals.
    2 context sentences
    Summary · context
    In this study, we aimed to evaluate the motor function, as well as the degree of demyelination and inflammatory changes in the brains of mice immunized for the myelin oligodendrocyte glycoprotein (MOG)35-55, and treated with Cerebrolysin.
    Summary · context
    Animals were randomly assigned to one of the three groups: (i) EAE untreated group (n=10), (ii) EAE treated group (n=10), and (iii) control group (n=5), and their motor dysfunction was followed until the clinical pathology begun to improve.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with autoimmune encephalitis, optical nerve myelin density differed significantly between Cerebrolysin-treated and untreated animals.

    In plain wordsIn mice with autoimmune encephalitis, optical nerve myelin density differed between Cerebrolysin-treated and untreated animals.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedOptical nerve myelin density
    Study

    mousen = 20

    Experimental autoimmune encephalitis
    Comparator
    Untreated EAE mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After harvesting the tissue, we have first evaluated the density of myelin in the optical nerves, cervical spinal cord and medulla and we found significant differences between treated and untreated groups of animals.
    2 context sentences
    Summary · context
    In this study, we aimed to evaluate the motor function, as well as the degree of demyelination and inflammatory changes in the brains of mice immunized for the myelin oligodendrocyte glycoprotein (MOG)35-55, and treated with Cerebrolysin.
    Summary · context
    Animals were randomly assigned to one of the three groups: (i) EAE untreated group (n=10), (ii) EAE treated group (n=10), and (iii) control group (n=5), and their motor dysfunction was followed until the clinical pathology begun to improve.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with autoimmune encephalitis, cervical spinal cord myelin density differed significantly between Cerebrolysin-treated and untreated animals.

    In plain wordsIn mice with autoimmune encephalitis, cervical spinal cord myelin density differed between Cerebrolysin-treated and untreated animals.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedCervical spinal cord myelin density
    Study

    mousen = 20

    Experimental autoimmune encephalitis
    Comparator
    Untreated EAE mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After harvesting the tissue, we have first evaluated the density of myelin in the optical nerves, cervical spinal cord and medulla and we found significant differences between treated and untreated groups of animals.
    2 context sentences
    Summary · context
    In this study, we aimed to evaluate the motor function, as well as the degree of demyelination and inflammatory changes in the brains of mice immunized for the myelin oligodendrocyte glycoprotein (MOG)35-55, and treated with Cerebrolysin.
    Summary · context
    Animals were randomly assigned to one of the three groups: (i) EAE untreated group (n=10), (ii) EAE treated group (n=10), and (iii) control group (n=5), and their motor dysfunction was followed until the clinical pathology begun to improve.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with autoimmune encephalitis, medulla myelin density differed significantly between Cerebrolysin-treated and untreated animals.

    In plain wordsIn mice with autoimmune encephalitis, medulla myelin density differed between Cerebrolysin-treated and untreated animals.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedMedulla myelin density
    Study

    mousen = 20

    Experimental autoimmune encephalitis
    Comparator
    Untreated EAE mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After harvesting the tissue, we have first evaluated the density of myelin in the optical nerves, cervical spinal cord and medulla and we found significant differences between treated and untreated groups of animals.
    2 context sentences
    Summary · context
    In this study, we aimed to evaluate the motor function, as well as the degree of demyelination and inflammatory changes in the brains of mice immunized for the myelin oligodendrocyte glycoprotein (MOG)35-55, and treated with Cerebrolysin.
    Summary · context
    Animals were randomly assigned to one of the three groups: (i) EAE untreated group (n=10), (ii) EAE treated group (n=10), and (iii) control group (n=5), and their motor dysfunction was followed until the clinical pathology begun to improve.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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