Cerebrolysin Reduces Astrogliosis and Axonal Injury and Enhances Neurogenesis in Rats After Closed Head Injury.

Zhang Y, Chopp M, Zhang ZG, Zhang Y, Zhang L, Lu M, Zhang T, Winter S, Doppler E, Brandstäetter H, Mahmood A, Xiong Y

Neurorehabilitation and neural repair30 Nov 2018Cited by 24 (Europe PMC)

PMID30499355DOI10.1177/1545968318809916PepBankPUB-30499355

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with mild TBI, cerebrolysin significantly reduced amyloid precursor protein accumulation versus placebo.
In plain wordsIn rats with brain injury, cerebrolysin reduced amyloid precursor protein accumulation compared with placebo.
Peptide
Cerebrolysin
Outcome
DecreaseAmyloid precursor protein accumulation
Study
ratn: not reported in source
Closed head impact mild traumatic brain injury
Comparator
Placebo
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.8, 2.5, 7.5 mL/kg · 10 consecutive daysAs given in this study (rat).
Source sentences
Summary
Compared with placebo, cerebrolysin significantly reduced amyloid precursor protein accumulation, astrogliosis, and axonal damage in various brain regions and increased the number of neuroblasts and neurogenesis in the dentate gyrus.
1 context sentence(design, population, supporting numbers)
Summary · context
adult Wistar rats with mild TBI induced by a closed head impact were randomly assigned to one of the cerebrolysin dose groups (0.8, 2.5, 7.5 mL/kg) or placebo
Report a problemFND-3049935501
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with mild TBI, cerebrolysin significantly reduced astrogliosis versus placebo.
In plain wordsIn rats with brain injury, cerebrolysin reduced astrogliosis compared with placebo.
Peptide
Cerebrolysin
Outcome
DecreaseAstrogliosis
Study
ratn: not reported in source
Closed head impact mild traumatic brain injury
Comparator
Placebo
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.8, 2.5, 7.5 mL/kg · 10 consecutive daysAs given in this study (rat).
Source sentences
Summary
Compared with placebo, cerebrolysin significantly reduced amyloid precursor protein accumulation, astrogliosis, and axonal damage in various brain regions and increased the number of neuroblasts and neurogenesis in the dentate gyrus.
1 context sentence(design, population, supporting numbers)
Summary · context
adult Wistar rats with mild TBI induced by a closed head impact were randomly assigned to one of the cerebrolysin dose groups (0.8, 2.5, 7.5 mL/kg) or placebo
Report a problemFND-3049935502
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with mild TBI, cerebrolysin significantly reduced axonal damage versus placebo.
In plain wordsIn rats with brain injury, cerebrolysin reduced axonal damage compared with placebo.
Peptide
Cerebrolysin
Outcome
DecreaseAxonal damage
Study
ratn: not reported in source
Closed head impact mild traumatic brain injury
Comparator
Placebo
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.8, 2.5, 7.5 mL/kg · 10 consecutive daysAs given in this study (rat).
Source sentences
Summary
Compared with placebo, cerebrolysin significantly reduced amyloid precursor protein accumulation, astrogliosis, and axonal damage in various brain regions and increased the number of neuroblasts and neurogenesis in the dentate gyrus.
1 context sentence(design, population, supporting numbers)
Summary · context
adult Wistar rats with mild TBI induced by a closed head impact were randomly assigned to one of the cerebrolysin dose groups (0.8, 2.5, 7.5 mL/kg) or placebo
Report a problemFND-3049935503
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with mild TBI, cerebrolysin increased neuroblast numbers in the dentate gyrus versus placebo.
In plain wordsIn rats with brain injury, cerebrolysin increased new immature neurons compared with placebo.
Peptide
Cerebrolysin
Outcome
IncreaseDentate gyrus neuroblast number
Study
ratn: not reported in source
Closed head impact mild traumatic brain injury
Comparator
Placebo
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.8, 2.5, 7.5 mL/kg · 10 consecutive daysAs given in this study (rat).
Source sentences
Summary
Compared with placebo, cerebrolysin significantly reduced amyloid precursor protein accumulation, astrogliosis, and axonal damage in various brain regions and increased the number of neuroblasts and neurogenesis in the dentate gyrus.
1 context sentence(design, population, supporting numbers)
Summary · context
adult Wistar rats with mild TBI induced by a closed head impact were randomly assigned to one of the cerebrolysin dose groups (0.8, 2.5, 7.5 mL/kg) or placebo
Report a problemFND-3049935504
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with mild TBI, cerebrolysin increased dentate gyrus neurogenesis versus placebo.
In plain wordsIn rats with brain injury, cerebrolysin increased formation of new neurons compared with placebo.
Peptide
Cerebrolysin
Outcome
IncreaseDentate gyrus neurogenesis
Study
ratn: not reported in source
Closed head impact mild traumatic brain injury
Comparator
Placebo
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.8, 2.5, 7.5 mL/kg · 10 consecutive daysAs given in this study (rat).
Source sentences
Summary
Compared with placebo, cerebrolysin significantly reduced amyloid precursor protein accumulation, astrogliosis, and axonal damage in various brain regions and increased the number of neuroblasts and neurogenesis in the dentate gyrus.
1 context sentence(design, population, supporting numbers)
Summary · context
adult Wistar rats with mild TBI induced by a closed head impact were randomly assigned to one of the cerebrolysin dose groups (0.8, 2.5, 7.5 mL/kg) or placebo
Report a problemFND-3049935505
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with mild TBI, cerebrolysin showed a significant dose effect on functional outcomes at 3 months versus saline.
In plain wordsIn rats with brain injury, cerebrolysin showed a dose effect on function compared with saline.
Peptide
Cerebrolysin
Outcome
Not applicableFunctional outcome dose effect
Study
ratn: not reported in source
Closed head impact mild traumatic brain injury
Comparator
Saline
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
0.8, 2.5, 7.5 mL/kg · 10 consecutive daysAs given in this study (rat).
Source sentences
Summary
There was a significant dose effect of cerebrolysin on functional outcomes at 3 months after injury compared with saline treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
adult Wistar rats with mild TBI induced by a closed head impact were randomly assigned to one of the cerebrolysin dose groups (0.8, 2.5, 7.5 mL/kg) or placebo
Report a problemFND-3049935506
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with mild TBI, cerebrolysin at ⩾0.8 mL/kg significantly improved cognitive function versus saline.
In plain wordsIn rats with brain injury, cerebrolysin improved cognitive function compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseCognitive function
Study
ratn: not reported in source
Closed head impact mild traumatic brain injury
Comparator
Saline
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
⩾0.8 mL/kg · 10 consecutive daysAs given in this study (rat).
Source sentences
Summary
Cerebrolysin at a dose of ⩾0.8 mL/kg significantly improved cognitive function, whereas at a dose of ⩾2.5 mL/kg, cerebrolysin also significantly improved sensorimotor function at various time points.
2 context sentences(design, population, supporting numbers)
Summary · context
There was a significant dose effect of cerebrolysin on functional outcomes at 3 months after injury compared with saline treatment.
Summary · context
adult Wistar rats with mild TBI induced by a closed head impact were randomly assigned to one of the cerebrolysin dose groups (0.8, 2.5, 7.5 mL/kg) or placebo
Report a problemFND-3049935507
08AnimalAnimal study (in vivo)Efficacy outcome
In rats with mild TBI, cerebrolysin at ⩾2.5 mL/kg significantly improved sensorimotor function versus saline at various times.
In plain wordsIn rats with brain injury, cerebrolysin improved sensorimotor function compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseSensorimotor function
Study
ratn: not reported in source
Closed head impact mild traumatic brain injury
Comparator
Saline
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
⩾2.5 mL/kg · 10 consecutive daysAs given in this study (rat).
Source sentences
Summary
Cerebrolysin at a dose of ⩾0.8 mL/kg significantly improved cognitive function, whereas at a dose of ⩾2.5 mL/kg, cerebrolysin also significantly improved sensorimotor function at various time points.
2 context sentences(design, population, supporting numbers)
Summary · context
There was a significant dose effect of cerebrolysin on functional outcomes at 3 months after injury compared with saline treatment.
Summary · context
adult Wistar rats with mild TBI induced by a closed head impact were randomly assigned to one of the cerebrolysin dose groups (0.8, 2.5, 7.5 mL/kg) or placebo
Report a problemFND-3049935508

Studies that did not test the peptide alone1

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

09AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Other
In rats with mild TBI studied with cerebrolysin, multiple histological and functional outcomes correlated significantly 90 days after injury.
In plain wordsIn rats with brain injury studied with cerebrolysin, tissue findings were linked to functional outcomes.
Peptide
Cerebrolysin
Outcome
Not applicableHistological and functional outcome correlations
Study
ratn: not reported in source
Closed head impact mild traumatic brain injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
There were significant correlations between multiple histological and functional outcomes 90 days after mTBI.
1 context sentence(design, population, supporting numbers)
Summary · context
adult Wistar rats with mild TBI induced by a closed head impact were randomly assigned to one of the cerebrolysin dose groups (0.8, 2.5, 7.5 mL/kg) or placebo
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3049935509

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownPhase 4NCT06078215

CERebrolysine Effect on Blood-brain Barrier in acUte Ischemic Stroke

Poznan University of Medical Sciencesn = 35010 Jan 2023 to est. 31 Mar 2025

Acute Ischemic Stroke

Trial page ClinicalTrials.govUpdated 13 Oct 2023

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.