Endogenous Oxytocin Levels in Relation to Food Intake, Menstrual Phase, and Age in Females.

Aulinas A, Pulumo RL, Asanza E, Mancuso CJ, Slattery M, Tolley C, Plessow F, Thomas JJ, Eddy KT, Miller KK, Klibanski A, Misra M, Lawson EA

The Journal of clinical endocrinology and metabolism1 Apr 2019Cited by 31 (Europe PMC)

PMID30445502PMCIDPMC6408871DOI10.1210/jc.2018-02036PepBankPUB-30445502

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In healthy females aged 10 to 45 years, mean fasting levels of the body's own oxytocin were 1011.2 pg/mL.
In plain wordsIn healthy girls and women aged 10 to 45, the body's own oxytocin level while fasting averaged 1011.2 pg/mL.
Peptide
Oxytocin
Outcome
Not applicableFasting oxytocin level
Study
n = 55
Outcome group
Endogenous peptide levels · Endocrine and hormones
Measurements
Mean fasting oxytocin
1011.2 pg/mL
fasting
Source sentences
Summary
Mean fasting oxytocin levels were 1011.2 ± 52.3 pg/mL (SEM)
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-five healthy females (age 10 to 45 years).
Summary · context
A standardized mixed meal was administered.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3044550201
02HumanEndogenous levelObservational studyOther
In healthy females, the body's own oxytocin levels decreased at 30 and 60 minutes after a standardized mixed meal, by 19.6% from baseline to nadir.
In plain wordsIn healthy girls and women, the body's own oxytocin level fell after a meal, by 19.6% at its lowest.
Peptide
Oxytocin
Outcome
DecreasePostprandial change in oxytocin
Study
n = 55
Outcome group
Appetite and food intake · Endocrine and hormones
Measurements
Decrease baseline to nadir
19.6%
after mixed meal
Source sentences
Summary
Mean fasting oxytocin levels were 1011.2 ± 52.3 pg/mL (SEM) and decreased at 30 and 60 minutes postmeal (P = 0.001 and P = 0.003, respectively). Mean oxytocin levels decreased19.6% ± 3.0% from baseline to nadir.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-five healthy females (age 10 to 45 years).
Summary · context
A standardized mixed meal was administered.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3044550202
03HumanEndogenous levelObservational studyOther
In healthy females, the body's own oxytocin area under the curve was lower in the early to midfollicular menstrual cycle phase.
In plain wordsIn healthy girls and women, the body's own oxytocin after a meal was lower in the early to mid follicular phase of the cycle.
Peptide
Oxytocin
Outcome
DecreaseOxytocin AUC by menstrual phase
Study
n = 55
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Oxytocin area under the curve was lower in the early to midfollicular menstrual cycle phase (P = 0.0003)
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-five healthy females (age 10 to 45 years).
Summary · context
A standardized mixed meal was administered.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3044550203
04HumanEndogenous levelObservational studyOther
In healthy females, the body's own oxytocin area under the curve was higher in younger females.
In plain wordsIn healthy girls and women, the body's own oxytocin after a meal was higher in younger females.
Peptide
Oxytocin
Outcome
IncreaseOxytocin AUC by age
Study
n = 55
Outcome group
Aging markers · Endocrine and hormones
Source sentences
Summary
Oxytocin area under the curve was lower in the early to midfollicular menstrual cycle phase (P = 0.0003) and higher in younger females (P = 0.002)
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-five healthy females (age 10 to 45 years).
Summary · context
A standardized mixed meal was administered.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3044550204
05HumanEndogenous levelObservational studyOther
In healthy females, the percent change in the body's own oxytocin from baseline to nadir was associated with postprandial hunger (rs = -0.291), and this remained significant after controlling for calories, menstrual cycle status and age.
In plain wordsIn healthy girls and women, the size of the after-meal drop in the body's own oxytocin was linked to how hungry they felt.
Peptide
Oxytocin
Outcome
Not applicableAssociation of oxytocin change with postprandial hunger
Study
n = 55
Outcome group
Appetite and food intake · Endocrine and hormones
Measurements
Spearman correlation with hunger
−0.291 rs
percent change in oxytocin
Source sentences
Summary
The percent change in oxytocin (baseline to nadir) was associated with postprandial hunger (rs = -0.291, P = 0.03) and fullness (rs = 0.345, P = 0.009). These relations remained significant after controlling for calories consumed, menstrual cycle status, and age (P = 0.023 and P = 0.0001, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-five healthy females (age 10 to 45 years).
Summary · context
A standardized mixed meal was administered.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3044550205
06HumanEndogenous levelObservational studyOther
In healthy females, the percent change in the body's own oxytocin from baseline to nadir was associated with postprandial fullness (rs = 0.345), and this remained significant after controlling for calories, menstrual cycle status and age.
In plain wordsIn healthy girls and women, the size of the after-meal drop in the body's own oxytocin was linked to how full they felt.
Peptide
Oxytocin
Outcome
Not applicableAssociation of oxytocin change with postprandial fullness
Study
n = 55
Outcome group
Appetite and food intake · Endocrine and hormones
Measurements
Spearman correlation with fullness
0.345 rs
percent change in oxytocin
Source sentences
Summary
The percent change in oxytocin (baseline to nadir) was associated with postprandial hunger (rs = -0.291, P = 0.03) and fullness (rs = 0.345, P = 0.009). These relations remained significant after controlling for calories consumed, menstrual cycle status, and age (P = 0.023 and P = 0.0001, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-five healthy females (age 10 to 45 years).
Summary · context
A standardized mixed meal was administered.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3044550206

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:48 UTC
First added · source update from Europe PMC

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