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Study · Non-randomized trial · 2019

1 result

Insulin glargine/lixisenatide fixed-ratio combination improves glycaemic variability and control without increasing hypoglycaemia.

Aronson R, Umpierrez G, Stager W, Kovatchev B

Diabetes, obesity & metabolism10 Dec 2018Cited by 15 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In patients with diabetes, iGlarLixi improved SMPG, SD of SMPG, HBGI, AUCn, MAG, and MAGE versus insulin glargine at week 30.

    In plain wordsIn patients with diabetes, iGlarLixi improved SMPG, SD of SMPG, HBGI, AUCn, MAG, and MAGE versus insulin glargine at week 30.

    Outcome
    Direction not reportedGlycemic variability markers
    Study

    n: not reported in source

    Comparator
    Insulin glargine
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Significant improvements were observed in SMPG, SD of SMPG, HBGI, AUCn, MAG and MAGE compared with iGlar, and in SMPG, HBGI and AUCn, compared with Lixi.
    2 context sentences
    Summary · context
    The GV features that were measured were mean and SD of self-measured plasma glucose (SMPG), high blood glucose index (HBGI) and low blood glucose index, area under the SMPG curve for each patient (AUCn), mean absolute glucose (MAG) and mean amplitude of glycaemic excursions (MAGE).
    Summary · context
    By week 30, iGlarLixi improved all GV markers from baseline, with no increased hypoglycaemia risk.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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