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Study · Animal study (in vivo) · rabbit · 2018

9 results

Comparative effects of methylprednisolone and tetracosactide (ACTH1-24) on ischemia/reperfusion injury of the rabbit spinal cord.

Kertmen H, Celikoglu E, Ozturk OC, Gürer B, Bozkurt H, Kanat MA, Arikok AT, Erguder BI, Sargon MF, Sekerci Z

Archives of medical science : AMS31 Jan 2017Cited by 17 (Europe PMC)

PMID30393502 (opens in a new tab)PMCIDPMC6209702 (opens in a new tab)DOI10.5114/aoms.2017.65650 (opens in a new tab)PepBankPUB-30393502
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with spinal cord ischemia-reperfusion injury, tetracosactide reduced tissue myeloperoxidase (p < 0.001).

    In plain wordsIn rabbits with spinal cord injury, tetracosactide reduced tissue myeloperoxidase.

    Peptide
    Cosyntropin
    Outcome
    DecreaseTissue myeloperoxidase
    Study

    rabbitn: not reported in source

    Spinal cord ischemia-reperfusion injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After the administration of tetracosactide, declines were seen in the tissue myeloperoxidase levels (p p = 0.003), xanthine oxidase action (p p < 0.001).
    2 context sentences
    Summary · context
    Rabbits were randomized into the accompanying four groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (methylprednisolone) and group 4 (tetracosactide).
    Summary · context
    In the various groups, the spinal cord ischemia model was made by the impediment of the aorta only caudal to the renal vein.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with spinal cord ischemia-reperfusion injury, tetracosactide reduced tissue malondialdehyde (p = 0.003).

    In plain wordsIn rabbits with spinal cord injury, tetracosactide reduced tissue malondialdehyde.

    Peptide
    Cosyntropin
    Outcome
    DecreaseTissue malondialdehyde
    Study

    rabbitn: not reported in source

    Spinal cord ischemia-reperfusion injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After the administration of tetracosactide, declines were seen in the tissue myeloperoxidase levels (p p = 0.003), xanthine oxidase action (p p < 0.001).
    2 context sentences
    Summary · context
    Rabbits were randomized into the accompanying four groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (methylprednisolone) and group 4 (tetracosactide).
    Summary · context
    In the various groups, the spinal cord ischemia model was made by the impediment of the aorta only caudal to the renal vein.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with spinal cord ischemia-reperfusion injury, tetracosactide reduced xanthine oxidase activity (p < 0.001).

    In plain wordsIn rabbits with spinal cord injury, tetracosactide reduced xanthine oxidase activity.

    Peptide
    Cosyntropin
    Outcome
    DecreaseXanthine oxidase activity
    Study

    rabbitn: not reported in source

    Spinal cord ischemia-reperfusion injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After the administration of tetracosactide, declines were seen in the tissue myeloperoxidase levels (p p = 0.003), xanthine oxidase action (p p < 0.001).
    2 context sentences
    Summary · context
    Rabbits were randomized into the accompanying four groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (methylprednisolone) and group 4 (tetracosactide).
    Summary · context
    In the various groups, the spinal cord ischemia model was made by the impediment of the aorta only caudal to the renal vein.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with spinal cord ischemia-reperfusion injury, tetracosactide reduced caspase-3 activity (p < 0.001).

    In plain wordsIn rabbits with spinal cord injury, tetracosactide reduced caspase-3 activity.

    Peptide
    Cosyntropin
    Outcome
    DecreaseCaspase-3 activity
    Study

    rabbitn: not reported in source

    Spinal cord ischemia-reperfusion injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After the administration of tetracosactide, declines were seen in the tissue myeloperoxidase levels (p p = 0.003), xanthine oxidase action (p p < 0.001).
    2 context sentences
    Summary · context
    Rabbits were randomized into the accompanying four groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (methylprednisolone) and group 4 (tetracosactide).
    Summary · context
    In the various groups, the spinal cord ischemia model was made by the impediment of the aorta only caudal to the renal vein.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with spinal cord ischemia-reperfusion injury, tetracosactide increased serum catalase (p < 0.001).

    In plain wordsIn rabbits with spinal cord injury, tetracosactide increased serum catalase.

    Peptide
    Cosyntropin
    Outcome
    IncreaseSerum catalase
    Study

    rabbitn: not reported in source

    Spinal cord ischemia-reperfusion injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Conversely, both the serum and tissue catalase levels were expanded (p < 0.001).
    2 context sentences
    Summary · context
    Rabbits were randomized into the accompanying four groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (methylprednisolone) and group 4 (tetracosactide).
    Summary · context
    In the various groups, the spinal cord ischemia model was made by the impediment of the aorta only caudal to the renal vein.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with spinal cord ischemia-reperfusion injury, tetracosactide increased tissue catalase (p < 0.001).

    In plain wordsIn rabbits with spinal cord injury, tetracosactide increased tissue catalase.

    Peptide
    Cosyntropin
    Outcome
    IncreaseTissue catalase
    Study

    rabbitn: not reported in source

    Spinal cord ischemia-reperfusion injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Conversely, both the serum and tissue catalase levels were expanded (p < 0.001).
    2 context sentences
    Summary · context
    Rabbits were randomized into the accompanying four groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (methylprednisolone) and group 4 (tetracosactide).
    Summary · context
    In the various groups, the spinal cord ischemia model was made by the impediment of the aorta only caudal to the renal vein.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with spinal cord ischemia-reperfusion injury, tetracosactide improved histopathological scores (p < 0.001).

    In plain wordsIn rabbits with spinal cord injury, tetracosactide improved histopathological scores.

    Peptide
    Cosyntropin
    Outcome
    Direction not reportedHistopathological score
    Study

    rabbitn: not reported in source

    Spinal cord ischemia-reperfusion injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Besides, tetracosactide treatment indicated enhanced results related to the histopathological scores (p p = 0.008) and the Tarlov scores (p < 0.001).
    2 context sentences
    Summary · context
    Rabbits were randomized into the accompanying four groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (methylprednisolone) and group 4 (tetracosactide).
    Summary · context
    In the various groups, the spinal cord ischemia model was made by the impediment of the aorta only caudal to the renal vein.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with spinal cord ischemia-reperfusion injury, tetracosactide improved the ultrastructural score (p = 0.008).

    In plain wordsIn rabbits with spinal cord injury, tetracosactide improved the ultrastructural score.

    Peptide
    Cosyntropin
    Outcome
    Direction not reportedUltrastructural score
    Study

    rabbitn: not reported in source

    Spinal cord ischemia-reperfusion injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Besides, tetracosactide treatment indicated enhanced results related to the histopathological scores (p p = 0.008) and the Tarlov scores (p < 0.001).
    2 context sentences
    Summary · context
    Rabbits were randomized into the accompanying four groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (methylprednisolone) and group 4 (tetracosactide).
    Summary · context
    In the various groups, the spinal cord ischemia model was made by the impediment of the aorta only caudal to the renal vein.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with spinal cord ischemia-reperfusion injury, tetracosactide improved Tarlov scores (p < 0.001).

    In plain wordsIn rabbits with spinal cord injury, tetracosactide improved Tarlov scores.

    Peptide
    Cosyntropin
    Outcome
    Direction not reportedTarlov score
    Study

    rabbitn: not reported in source

    Spinal cord ischemia-reperfusion injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Besides, tetracosactide treatment indicated enhanced results related to the histopathological scores (p p = 0.008) and the Tarlov scores (p < 0.001).
    2 context sentences
    Summary · context
    Rabbits were randomized into the accompanying four groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (methylprednisolone) and group 4 (tetracosactide).
    Summary · context
    In the various groups, the spinal cord ischemia model was made by the impediment of the aorta only caudal to the renal vein.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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