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Study · Randomized controlled trial · n = 61 · 2019

2 results

Post-retrieval oxytocin facilitates next day extinction of threat memory in humans.

Hu J, Wang Z, Feng X, Long C, Schiller D

Psychopharmacology29 Oct 2018Cited by 14 (Europe PMC)

PMID30370450 (opens in a new tab)PMCIDPMC6374199 (opens in a new tab)DOI10.1007/s00213-018-5074-6 (opens in a new tab)PepBankPUB-30370450
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy adults, stimulus discrimination during the early phase of extinction on day 3 was equivalent in all groups, including those given oxytocin.

    In plain wordsIn healthy adults, oxytocin did not change how well people told threat cues apart early in extinction on day 3.

    Peptide
    Oxytocin
    Outcome
    No significant changeStimulus discrimination, early extinction phase
    Study

    n = 61

    Comparator
    Placebo after retrieval; oxytocin without retrieval
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    On day 3, all groups showed equivalent stimulus discrimination during the early phase of extinction.
    2 context sentences
    Summary · context
    In a double-blind, randomized, placebo-controlled, between-subject design, 61 healthy human individuals completed a 3-day experiment.
    Summary · context
    On day 2, the participants were randomized to receive an intranasal dose of OT (40 IU) or placebo after memory retrieval, or an intranasal dose of OT (40 IU) without retrieval.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy adults, intranasal oxytocin given after a memory reminder produced a greater decline in stimulus discrimination by the late extinction phase than placebo after a reminder or oxytocin without a reminder.

    In plain wordsIn healthy adults, oxytocin after a memory reminder led to a greater fall in threat discrimination late in extinction than placebo or oxytocin alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseStimulus discrimination, late extinction phase
    Study

    n = 61

    Comparator
    Placebo after retrieval; oxytocin without retrieval
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    However, the group that received OT following a memory reminder showed a greater decline in stimulus discrimination by the late phase of extinction relative to the two other groups.
    2 context sentences
    Summary · context
    In a double-blind, randomized, placebo-controlled, between-subject design, 61 healthy human individuals completed a 3-day experiment.
    Summary · context
    On day 2, the participants were randomized to receive an intranasal dose of OT (40 IU) or placebo after memory retrieval, or an intranasal dose of OT (40 IU) without retrieval.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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