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Study · Randomized controlled trial · 2019

15 results

Bone mineral density response rates are greater in patients treated with abaloparatide compared with those treated with placebo or teriparatide: Results from the ACTIVE phase 3 trial.

Miller PD, Hattersley G, Lau E, Fitzpatrick LA, Harris AG, Williams GC, Hu MY, Riis BJ, Russo L, Christiansen C

Bone22 Oct 2018Cited by 54 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. 15 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In women with postmenopausal osteoporosis, 19.1% with abaloparatide versus 0.9% with placebo gained >3% BMD at all three skeletal sites at month 6.

    In plain wordsIn women with osteoporosis, abaloparatide had more responders than placebo for >3% bone density gains at all three sites.

    Outcome
    Increase>3% BMD responders at month 6
    Study

    n: not reported in source

    Comparator
    Placebo
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Proportion of >3% BMD responders at month 6
    19.1%
    abaloparatide
    Proportion of >3% BMD responders at month 6
    0.9%
    placebo

    Source sentences

    Summary
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    3 context sentences
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women with postmenopausal osteoporosis, 19.1% with abaloparatide versus 6.5% with teriparatide gained >3% BMD at all three skeletal sites at month 6.

    In plain wordsIn women with osteoporosis, abaloparatide had more responders than teriparatide for >3% bone density gains at all three sites.

    Outcome
    Increase>3% BMD responders at month 6
    Study

    n: not reported in source

    Comparator
    Teriparatide
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Proportion of >3% BMD responders at month 6
    19.1%
    abaloparatide
    Proportion of >3% BMD responders at month 6
    6.5%
    teriparatide

    Source sentences

    Summary
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    3 context sentences
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In women with postmenopausal osteoporosis, 33.2% with abaloparatide versus 1.5% with placebo gained >3% BMD at all three skeletal sites at month 12.

    In plain wordsIn women with osteoporosis, abaloparatide had more responders than placebo for >3% bone density gains at all three sites.

    Outcome
    Increase>3% BMD responders at month 12
    Study

    n: not reported in source

    Comparator
    Placebo
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Proportion of >3% BMD responders at month 12
    33.2%
    abaloparatide
    Proportion of >3% BMD responders at month 12
    1.5%
    placebo

    Source sentences

    Summary
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    3 context sentences
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In women with postmenopausal osteoporosis, 33.2% with abaloparatide versus 19.8% with teriparatide gained >3% BMD at all three skeletal sites at month 12.

    In plain wordsIn women with osteoporosis, abaloparatide had more responders than teriparatide for >3% bone density gains at all three sites.

    Outcome
    Increase>3% BMD responders at month 12
    Study

    n: not reported in source

    Comparator
    Teriparatide
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Proportion of >3% BMD responders at month 12
    33.2%
    abaloparatide
    Proportion of >3% BMD responders at month 12
    19.8%
    teriparatide

    Source sentences

    Summary
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    3 context sentences
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In women with postmenopausal osteoporosis, 44.5% with abaloparatide versus 1.9% with placebo gained >3% BMD at all three skeletal sites at month 18.

    In plain wordsIn women with osteoporosis, abaloparatide had more responders than placebo for >3% bone density gains at all three sites.

    Outcome
    Increase>3% BMD responders at month 18
    Study

    n: not reported in source

    Comparator
    Placebo
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Proportion of >3% BMD responders at month 18
    44.5%
    abaloparatide
    Proportion of >3% BMD responders at month 18
    1.9%
    placebo

    Source sentences

    Summary
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    3 context sentences
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In women with postmenopausal osteoporosis, 44.5% with abaloparatide versus 32.0% with teriparatide gained >3% BMD at all three skeletal sites at month 18.

    In plain wordsIn women with osteoporosis, abaloparatide had more responders than teriparatide for >3% bone density gains at all three sites.

    Outcome
    Increase>3% BMD responders at month 18
    Study

    n: not reported in source

    Comparator
    Teriparatide
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Proportion of >3% BMD responders at month 18
    44.5%
    abaloparatide
    Proportion of >3% BMD responders at month 18
    32%
    teriparatide

    Source sentences

    Summary
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    3 context sentences
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In women with postmenopausal osteoporosis, abaloparatide had more responders with >0% BMD gains at all three skeletal sites than placebo.

    In plain wordsIn women with osteoporosis, abaloparatide had more responders than placebo for >0% bone density gains at all three sites.

    Outcome
    Increase>0% BMD responders
    Study

    n: not reported in source

    Comparator
    Placebo
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Findings were similar for the >0% and >6% responder thresholds.
    4 context sentences
    Summary · context
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  8. 08HumanRandomized controlled trialEfficacy outcome

    In women with postmenopausal osteoporosis, abaloparatide had more responders with >0% BMD gains at all three skeletal sites than teriparatide.

    In plain wordsIn women with osteoporosis, abaloparatide had more responders than teriparatide for >0% bone density gains at all three sites.

    Outcome
    Increase>0% BMD responders
    Study

    n: not reported in source

    Comparator
    Teriparatide
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Findings were similar for the >0% and >6% responder thresholds.
    4 context sentences
    Summary · context
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  9. 09HumanRandomized controlled trialEfficacy outcome

    In women with postmenopausal osteoporosis, abaloparatide had more responders with >6% BMD gains at all three skeletal sites than placebo.

    In plain wordsIn women with osteoporosis, abaloparatide had more responders than placebo for >6% bone density gains at all three sites.

    Outcome
    Increase>6% BMD responders
    Study

    n: not reported in source

    Comparator
    Placebo
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Findings were similar for the >0% and >6% responder thresholds.
    4 context sentences
    Summary · context
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  10. 10HumanRandomized controlled trialEfficacy outcome

    In women with postmenopausal osteoporosis, abaloparatide had more responders with >6% BMD gains at all three skeletal sites than teriparatide.

    In plain wordsIn women with osteoporosis, abaloparatide had more responders than teriparatide for >6% bone density gains at all three sites.

    Outcome
    Increase>6% BMD responders
    Study

    n: not reported in source

    Comparator
    Teriparatide
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Findings were similar for the >0% and >6% responder thresholds.
    4 context sentences
    Summary · context
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  11. 11HumanObservational studyEfficacy outcome

    In women with postmenopausal osteoporosis, 6.5% with teriparatide versus 19.1% with abaloparatide gained >3% BMD at all three skeletal sites at month 6.

    In plain wordsIn women with osteoporosis, teriparatide had fewer responders than abaloparatide for >3% bone density gains at all three sites.

    Outcome
    Decrease>3% BMD responders at month 6
    Study

    n: not reported in source

    Comparator
    Abaloparatide
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Proportion of >3% BMD responders at month 6
    6.5%
    teriparatide
    Proportion of >3% BMD responders at month 6
    19.1%
    abaloparatide

    Source sentences

    Summary
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    3 context sentences
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  12. 12HumanObservational studyEfficacy outcome

    In women with postmenopausal osteoporosis, 19.8% with teriparatide versus 33.2% with abaloparatide gained >3% BMD at all three skeletal sites at month 12.

    In plain wordsIn women with osteoporosis, teriparatide had fewer responders than abaloparatide for >3% bone density gains at all three sites.

    Outcome
    Decrease>3% BMD responders at month 12
    Study

    n: not reported in source

    Comparator
    Abaloparatide
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    >3% BMD responders at month 12
    19.8%
    teriparatide group
    >3% BMD responders at month 12
    33.2%
    abaloparatide group (comparator)

    Source sentences

    Summary
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    3 context sentences
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  13. 13HumanObservational studyEfficacy outcome

    In women with postmenopausal osteoporosis, 32.0% with teriparatide versus 44.5% with abaloparatide gained >3% BMD at all three skeletal sites at month 18.

    In plain wordsIn women with osteoporosis, teriparatide had fewer responders than abaloparatide for >3% bone density gains at all three sites.

    Outcome
    Decrease>3% BMD responders at month 18
    Study

    n: not reported in source

    Comparator
    Abaloparatide
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    >3% BMD responders at month 18
    32%
    teriparatide group
    >3% BMD responders at month 18
    44.5%
    abaloparatide group (comparator)

    Source sentences

    Summary
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    3 context sentences
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  14. 14HumanObservational studyEfficacy outcome

    In women with postmenopausal osteoporosis, teriparatide had fewer responders with >0% BMD gains at all three skeletal sites than abaloparatide.

    In plain wordsIn women with osteoporosis, teriparatide had fewer responders than abaloparatide for >0% bone density gains at all three sites.

    Outcome
    Decrease>0% BMD responders
    Study

    n: not reported in source

    Comparator
    Abaloparatide
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Findings were similar for the >0% and >6% responder thresholds.
    4 context sentences
    Summary · context
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.
  15. 15HumanObservational studyEfficacy outcome

    In women with postmenopausal osteoporosis, teriparatide had fewer responders with >6% BMD gains at all three skeletal sites than abaloparatide.

    In plain wordsIn women with osteoporosis, teriparatide had fewer responders than abaloparatide for >6% bone density gains at all three sites.

    Outcome
    Decrease>6% BMD responders
    Study

    n: not reported in source

    Comparator
    Abaloparatide
    Analysis
    Exploratory
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Findings were similar for the >0% and >6% responder thresholds.
    4 context sentences
    Summary · context
    At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
    Summary · context
    Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
    Summary · context
    Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
    Summary · context
    Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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