In women with postmenopausal osteoporosis, 19.1% with abaloparatide versus 0.9% with placebo gained >3% BMD at all three skeletal sites at month 6.
In plain wordsIn women with osteoporosis, abaloparatide had more responders than placebo for >3% bone density gains at all three sites.
- Peptide
- Abaloparatide (Tymlos)
- Outcome
- Increase>3% BMD responders at month 6
- Study
n: not reported in source
- Comparator
- Placebo
- Analysis
- Exploratory
- Outcome group
- Bone and joint · Musculoskeletal
- Studied dose
- Dose not stated
Measurements
- Proportion of >3% BMD responders at month 6
- 19.1%
- abaloparatide
- Proportion of >3% BMD responders at month 6
- 0.9%
- placebo
Source sentences
At months 6, 12, and 18, there were significantly more >3% BMD responders in the abaloparatide group compared with placebo and teriparatide: month 6, 19.1% vs 0.9% for placebo and 6.5% for teriparatide; month 12, 33.2% vs 1.5% and 19.8%; month 18, 44.5% vs 1.9% and 32.0% (P < 0.001 for all compariso…
3 context sentences(design, population, supporting numbers)
Here, we report a prospective, exploratory BMD responder analysis from ACTIVE.
Proportions of patients experiencing BMD gains from baseline of >0%, >3%, and >6% at the total hip, femoral neck, and lumbar spine at 6, 12, and 18 months of treatment were compared among the placebo, abaloparatide, and teriparatide groups in ACTIVE.
Responders were defined prospectively as patients experiencing BMD gains at all 3 anatomic sites.