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Study · Measured the body's own peptide · 2019

1 result

Selective L4 Dorsal Root Ganglion Stimulation Evokes Pain Relief and Changes of Inflammatory Markers: Part I Profiling of Saliva and Serum Molecular Patterns.

Gravius N, Chaudhry SR, Muhammad S, Boström A, Gravius S, Randau T, Scheele D, Westhofen P, Kruppenbacher J, Stoffel-Wagner B, Maier C, Weidlich A and 5 more

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Yearwood TL, Chakravarthy KV, Kramer JM, Hurlemann R, Kinfe TM

Neuromodulation : journal of the International Neuromodulation Society25 Oct 2018Cited by 33 (Europe PMC)

PMID30358008 (opens in a new tab)DOI10.1111/ner.12866 (opens in a new tab)PepBankPUB-30358008
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialOther

    In patients with complex regional pain syndrome, the body's own saliva oxytocin concentration rose after three months of L4 dorsal root ganglion stimulation, but not significantly.

    In plain wordsIn people with complex regional pain syndrome, the body's own oxytocin in saliva rose a little after nerve stimulation, but not by a significant amount.

    Peptide
    Oxytocin
    Outcome
    No significant changeSaliva oxytocin concentration after L4 dorsal root ganglion stimulation
    Study

    n = 12

    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    saliva oxytocin concentrations increased in CRPS subjects after L4-DRGSTIM (p = 0.65).
    2 context sentences
    Summary · context
    saliva oxytocin nonsignificantly increased after L4-DRGSTIM .
    Summary · context
    This study enrolled 24 subjects (12 refractory CRPS patients plus suitably matched healthy controls) and performed immunoassays of inflammatory mediators in saliva and serum along with score-based assessments of pain, mood, and sleep quality at baseline and after three months of selective L4-DRGSTIM .

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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