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Study · Measured the body's own peptide · 2018

2 results

Independent elevation of peripheral oxytocin concentrations and reduction in cognitive empathy during 4-fluoroamphetamine intoxication.

Dolder PC, de Sousa Fernandes Perna EB, Mason NL, Hutten NRPW, Toennes SW, Theunissen EL, Ramaekers JG, Kuypers KPC

Human psychopharmacology25 Oct 2018Cited by 5 (Europe PMC)

PMID30357914 (opens in a new tab)DOI10.1002/hup.2680 (opens in a new tab)PepBankPUB-30357914
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialOther

    In healthy poly-drug users, 4-fluoroamphetamine increased plasma oxytocin levels one hour after treatment versus placebo.

    In plain wordsIn healthy drug users, 4-fluoroamphetamine raised the body's own oxytocin levels more than placebo did.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin one hour after 4-FA
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Hormone levels · Endocrine and hormones

    Source sentences

    Summary
    One hour after treatment, plasma oxytocin levels were significantly increased compared with placebo.
    2 context sentences
    Summary · context
    Twelve healthy poly-drug users were included in a double-blind placebo-controlled two-way crossover study.
    Summary · context
    Treatments were 4-FA (100 mg) and placebo; empathy was assessed by means of the multifaceted empathy test, and blood samples were taken before and after treatment administration to determine oxytocin concentrations.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialOther

    In healthy poly-drug users, the 4-fluoroamphetamine-induced rise in oxytocin was unrelated to the behavioral effects.

    In plain wordsIn healthy drug users, the rise in the body's own oxytocin after 4-fluoroamphetamine was not linked to the behavioral effects.

    Peptide
    Oxytocin
    Outcome
    No significant changeAssociation of oxytocin change with behavioral effects
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Hormone levels · Endocrine and hormones

    Source sentences

    Summary
    Behavioral and hormonal effects were unrelated.
    2 context sentences
    Summary · context
    Twelve healthy poly-drug users were included in a double-blind placebo-controlled two-way crossover study.
    Summary · context
    Treatments were 4-FA (100 mg) and placebo; empathy was assessed by means of the multifaceted empathy test, and blood samples were taken before and after treatment administration to determine oxytocin concentrations.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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