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Study · Observational study · n = 254 · 2018

6 results

Evaluation of Hypothalamic-Pituitary-Adrenal Axis by the GHRP2 Test: Comparison With the Insulin Tolerance Test.

Hayakawa T, Kitamura T, Tamada D, Mukai K, Hayashi R, Takahara M, Otsuki M, Shimomura I

Journal of the Endocrine Society26 Jun 2018Cited by 9 (Europe PMC)

PMID30324179 (opens in a new tab)PMCIDPMC6055535 (opens in a new tab)DOI10.1210/js.2018-00102 (opens in a new tab)PepBankPUB-30324179
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanObservational studyOther

    In 254 patients evaluated for hypopituitarism, maximum cortisol during the GHRP2 test correlated strongly with that during the insulin tolerance test.

    In plain wordsPeak cortisol after GHRP2 matched peak cortisol after the insulin test closely.

    Peptide
    GHRP-2
    Outcome
    Not applicableCorrelation of maximum cortisol between GHRP2T and ITT
    Study

    n = 254

    Comparator
    Insulin tolerance test
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Correlation
    0.777 r
    Fmax GHRP2T vs ITT

    Source sentences

    Summary
    A strong correlation was found between Fmax measured using both tests (r = 0.777, P < 0.0001).
    1 context sentence
    Summary · context
    The present retrospective study analyzed the clinical features and laboratory data from 254 patients admitted for evaluation of hypopituitarism who underwent both GHRP2T and ITT.
  2. 02HumanObservational studyOther

    The GHRP2 test had 64% sensitivity and 79% specificity against the insulin tolerance test, so it was not suitable for clinical use in the whole group.

    In plain wordsIn all patients together, the GHRP2 test missed too many cases to replace the insulin test.

    Peptide
    GHRP-2
    Outcome
    Not applicableSensitivity and specificity of GHRP2T for adrenal insufficiency
    Study

    n = 254

    Comparator
    Insulin tolerance test
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Sensitivity
    64%
    GHRP2T vs ITT, all patients
    Specificity
    79%
    GHRP2T vs ITT, all patients

    Source sentences

    Summary
    However, the sensitivity (64%) and specificity (79%) showed that the GHRP2T was not suitable for clinical use.
    1 context sentence
    Summary · context
    The present retrospective study analyzed the clinical features and laboratory data from 254 patients admitted for evaluation of hypopituitarism who underwent both GHRP2T and ITT.
  3. 03HumanObservational studyOther

    Functional adenoma and sex influenced the correlation between maximum cortisol in the two tests.

    In plain wordsThe match between the two tests depended on factors such as sex and a hormone-producing tumour.

    Peptide
    GHRP-2
    Outcome
    MixedFactors that influenced the correlation
    Study

    n = 254

    Comparator
    Insulin tolerance test
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Various factors influenced the correlation, probably through their effects on ghrelin and/or GHSR, including functional adenoma (P P < 0.05).
    1 context sentence
    Summary · context
    The present retrospective study analyzed the clinical features and laboratory data from 254 patients admitted for evaluation of hypopituitarism who underwent both GHRP2T and ITT.
  4. 04HumanObservational studyOther

    In male patients without functional adenoma, the GHRP2 test had 95% sensitivity and 85% specificity against the insulin tolerance test.

    In plain wordsIn men without a hormone-producing tumour, the GHRP2 test agreed well with the insulin test.

    Peptide
    GHRP-2
    Outcome
    Not applicableSensitivity and specificity of GHRP2T in men without functional adenoma
    Study

    n = 104

    Comparator
    Insulin tolerance test
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Sensitivity
    95%
    male, no functional adenoma
    Specificity
    85%
    male, no functional adenoma

    Source sentences

    Summary
    Analysis of the data from male subjects without functional adenoma (n = 104) showed high sensitivity (95%) and specificity (85%) for the GHRP2T.
    1 context sentence
    Summary · context
    The present retrospective study analyzed the clinical features and laboratory data from 254 patients admitted for evaluation of hypopituitarism who underwent both GHRP2T and ITT.
  5. 05HumanObservational studyOther

    In patients with prolactinoma, no substantial correlation was found between maximum cortisol in the two tests.

    In plain wordsIn patients with prolactinoma, the two tests did not match well.

    Peptide
    GHRP-2
    Outcome
    No significant changeCorrelation in patients with prolactinoma
    Study

    n = 30

    Comparator
    Insulin tolerance test
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No substantial correlation was found between Fmax measured using both tests in patients with prolactinoma (n = 30).
    1 context sentence
    Summary · context
    The present retrospective study analyzed the clinical features and laboratory data from 254 patients admitted for evaluation of hypopituitarism who underwent both GHRP2T and ITT.
  6. 06HumanObservational studyOther

    After exclusion of functional adenoma, age and menstruation significantly influenced the association in female patients, and no factor did so in male patients.

    In plain wordsIn women, age and menstruation changed how well the two tests matched. In men, no factor did.

    Peptide
    GHRP-2
    Outcome
    MixedFactors in women without functional adenoma
    Study

    n: not reported in source

    Comparator
    Insulin tolerance test
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The exclusion of patients with functional adenoma revealed no factors that affected the association in male patients; however, age and menstruation significantly influenced it in female patients (P < 0.05).
    1 context sentence
    Summary · context
    The present retrospective study analyzed the clinical features and laboratory data from 254 patients admitted for evaluation of hypopituitarism who underwent both GHRP2T and ITT.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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