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Study · Animal study (in vivo) · rat · 2018

6 results

Prevention of memory impairment induced by post-traumatic stress disorder by cerebrolysin.

Alzoubi KH, Al-Ibbini AM, Nuseir KQ

Psychiatry research6 Oct 2018Cited by 25 (Europe PMC)

PMID30316170 (opens in a new tab)DOI10.1016/j.psychres.2018.10.008 (opens in a new tab)PepBankPUB-30316170
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to single prolonged stress, Cerebrolysin prevented short-term memory impairment compared with vehicle.

    In plain wordsIn rats exposed to single prolonged stress, Cerebrolysin prevented short-term memory impairment compared with vehicle.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseShort-term memory impairment
    Study

    ratn: not reported in source

    Single prolonged stress model of PTSD
    Comparator
    SPS with vehicle
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Results showed that SPS impaired both short- and long- term memories; and chronic cerebrolysin administration prevented such effect.
    2 context sentences
    Summary · context
    To induce PTSD, the single prolonged stress (SPS) model was used.
    Summary · context
    Rats were allocated into four groups: control (vehicle-treated), CBL (administrated cerebrolysin 2.5 ml/kg by intraperitoneal route for 4 weeks), SPS (as a model of PTSD and administered vehicle), and CBL-SPS (exposed to SPS and administered cerebrolysin for 4 weeks).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to single prolonged stress, Cerebrolysin prevented long-term memory impairment compared with vehicle.

    In plain wordsIn rats exposed to single prolonged stress, Cerebrolysin prevented long-term memory impairment compared with vehicle.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseLong-term memory impairment
    Study

    ratn: not reported in source

    Single prolonged stress model of PTSD
    Comparator
    SPS with vehicle
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Results showed that SPS impaired both short- and long- term memories; and chronic cerebrolysin administration prevented such effect.
    2 context sentences
    Summary · context
    To induce PTSD, the single prolonged stress (SPS) model was used.
    Summary · context
    Rats were allocated into four groups: control (vehicle-treated), CBL (administrated cerebrolysin 2.5 ml/kg by intraperitoneal route for 4 weeks), SPS (as a model of PTSD and administered vehicle), and CBL-SPS (exposed to SPS and administered cerebrolysin for 4 weeks).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats exposed to single prolonged stress, Cerebrolysin prevented decreases in hippocampal GSH levels compared with vehicle.

    In plain wordsIn rats exposed to single prolonged stress, Cerebrolysin prevented decreases in hippocampal GSH levels compared with vehicle.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseHippocampal GSH levels
    Study

    ratn: not reported in source

    Single prolonged stress model of PTSD
    Comparator
    SPS with vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin also prevented decreases in hippocampal GSH levels and GSH/GSSG ratios, and increased GSSG and TBARs, levels induced by PTSD.
    2 context sentences
    Summary · context
    To induce PTSD, the single prolonged stress (SPS) model was used.
    Summary · context
    Rats were allocated into four groups: control (vehicle-treated), CBL (administrated cerebrolysin 2.5 ml/kg by intraperitoneal route for 4 weeks), SPS (as a model of PTSD and administered vehicle), and CBL-SPS (exposed to SPS and administered cerebrolysin for 4 weeks).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats exposed to single prolonged stress, Cerebrolysin prevented decreases in hippocampal GSH/GSSG ratios compared with vehicle.

    In plain wordsIn rats exposed to single prolonged stress, Cerebrolysin prevented decreases in hippocampal GSH/GSSG ratios compared with vehicle.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseHippocampal GSH/GSSG ratio
    Study

    ratn: not reported in source

    Single prolonged stress model of PTSD
    Comparator
    SPS with vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin also prevented decreases in hippocampal GSH levels and GSH/GSSG ratios, and increased GSSG and TBARs, levels induced by PTSD.
    2 context sentences
    Summary · context
    To induce PTSD, the single prolonged stress (SPS) model was used.
    Summary · context
    Rats were allocated into four groups: control (vehicle-treated), CBL (administrated cerebrolysin 2.5 ml/kg by intraperitoneal route for 4 weeks), SPS (as a model of PTSD and administered vehicle), and CBL-SPS (exposed to SPS and administered cerebrolysin for 4 weeks).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats exposed to single prolonged stress, Cerebrolysin prevented increased hippocampal GSSG levels compared with vehicle.

    In plain wordsIn rats exposed to single prolonged stress, Cerebrolysin prevented increased hippocampal GSSG levels compared with vehicle.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseHippocampal GSSG levels
    Study

    ratn: not reported in source

    Single prolonged stress model of PTSD
    Comparator
    SPS with vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin also prevented decreases in hippocampal GSH levels and GSH/GSSG ratios, and increased GSSG and TBARs, levels induced by PTSD.
    2 context sentences
    Summary · context
    To induce PTSD, the single prolonged stress (SPS) model was used.
    Summary · context
    Rats were allocated into four groups: control (vehicle-treated), CBL (administrated cerebrolysin 2.5 ml/kg by intraperitoneal route for 4 weeks), SPS (as a model of PTSD and administered vehicle), and CBL-SPS (exposed to SPS and administered cerebrolysin for 4 weeks).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats exposed to single prolonged stress, Cerebrolysin prevented increased hippocampal TBARs levels compared with vehicle.

    In plain wordsIn rats exposed to single prolonged stress, Cerebrolysin prevented increased hippocampal TBARs levels compared with vehicle.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseHippocampal TBARs levels
    Study

    ratn: not reported in source

    Single prolonged stress model of PTSD
    Comparator
    SPS with vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin also prevented decreases in hippocampal GSH levels and GSH/GSSG ratios, and increased GSSG and TBARs, levels induced by PTSD.
    2 context sentences
    Summary · context
    To induce PTSD, the single prolonged stress (SPS) model was used.
    Summary · context
    Rats were allocated into four groups: control (vehicle-treated), CBL (administrated cerebrolysin 2.5 ml/kg by intraperitoneal route for 4 weeks), SPS (as a model of PTSD and administered vehicle), and CBL-SPS (exposed to SPS and administered cerebrolysin for 4 weeks).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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