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Study · Not a test of the peptide alone · 2018

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It is Time to Carpe Diem with Porcine ACTH - A Comparison of Porcine Sequence Corticotropin to Tetracosactide Hexaacetate in Testing the Hypothalamic Pituitary Adrenal Axis in Healthy Individuals.

Wagmode NB, Mathew V, Bantwal G, Ayyar V, George B, Patanjali CP, Michael J

Indian journal of endocrinology and metabolism1 Sept 2018Cited by 10 (Europe PMC)

PMID30294573 (opens in a new tab)PMCIDPMC6166546 (opens in a new tab)DOI10.4103/ijem.ijem_114_18 (opens in a new tab)PepBankPUB-30294573
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cosyntropin.

  1. 01HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, tetracosactide produced mean serum cortisol of 30.3 (±7.83) μg/dl at 30 minutes.

    In plain wordsIn healthy volunteers, serum cortisol averaged 30.3 μg/dl at 30 minutes after tetracosactide.

    Peptide
    Cosyntropin
    Outcome
    Not applicableSerum cortisol at 30 minutes
    Study

    n = 15

    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    Serum cortisol
    30.3 μg/dl
    30 minutes
    Reported variability
    7.83 μg/dl
    30 minutes

    Source sentences

    Summary
    Mean serum cortisol values with tetracosactide were 30.3 (±7.83) μg/dl and 31.27 (±7.36) μg/dl at 30 and 60 minutes, respectively.
    1 context sentence
    Summary · context
    Fifteen healthy volunteers were enrolled. Serum cortisol was measured at 0 minute in all subjects and at 30 and 60 minutes after tetracosactide hexaacetate 250 μg intravenously. Four weeks later, serum cortisol level was measured at 0 minute and at 30 and 60 minutes following 24 units of porcine seq…

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  2. 02HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, tetracosactide produced mean serum cortisol of 31.27 (±7.36) μg/dl at 60 minutes.

    In plain wordsIn healthy volunteers, serum cortisol averaged 31.27 μg/dl at 60 minutes after tetracosactide.

    Peptide
    Cosyntropin
    Outcome
    Not applicableSerum cortisol at 60 minutes
    Study

    n = 15

    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    Serum cortisol
    31.27 μg/dl
    60 minutes
    Reported variability
    7.36 μg/dl
    60 minutes

    Source sentences

    Summary
    Mean serum cortisol values with tetracosactide were 30.3 (±7.83) μg/dl and 31.27 (±7.36) μg/dl at 30 and 60 minutes, respectively.
    1 context sentence
    Summary · context
    Fifteen healthy volunteers were enrolled. Serum cortisol was measured at 0 minute in all subjects and at 30 and 60 minutes after tetracosactide hexaacetate 250 μg intravenously. Four weeks later, serum cortisol level was measured at 0 minute and at 30 and 60 minutes following 24 units of porcine seq…

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  3. 03HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, all subjects had an adequate response at 30 minutes after tetracosactide.

    In plain wordsAll healthy volunteers had an adequate response at 30 minutes after tetracosactide.

    Peptide
    Cosyntropin
    Outcome
    Not applicableAdequate cortisol response at 30 minutes
    Study

    n = 15

    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Source sentences

    Summary
    All subjects had a response qualified as normal or adequate at 30 minutes itself.
    1 context sentence
    Summary · context
    Fifteen healthy volunteers were enrolled. Serum cortisol was measured at 0 minute in all subjects and at 30 and 60 minutes after tetracosactide hexaacetate 250 μg intravenously. Four weeks later, serum cortisol level was measured at 0 minute and at 30 and 60 minutes following 24 units of porcine seq…

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  4. 04HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, peak cortisol was comparable with tetracosactide and porcine sequence corticotropin (P = 0.686).

    In plain wordsIn healthy volunteers, tetracosactide and porcine sequence corticotropin produced comparable peak cortisol.

    Peptide
    Cosyntropin
    Outcome
    No significant changePeak serum cortisol
    Study

    n = 15

    Comparator
    Porcine sequence corticotropin
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    Peak cortisol
    32.65 μg/dl
    tetracosactide
    Reported variability
    7.76 μg/dl
    tetracosactide
    Peak cortisol
    31.59 μg/dl
    porcine sequence corticotropin
    Reported variability
    6.4 μg/dl
    porcine sequence corticotropin
    P
    0.686
    between treatments

    Source sentences

    Summary
    Mean peak serum cortisol response was 32.65 (±7.76) μg/dl in tetracosactide group and 31.59 (±6.4) μg/dl in porcine sequence corticotropin group, and the responses in two groups were comparable (P = 0.686).
    1 context sentence
    Summary · context
    Fifteen healthy volunteers were enrolled. Serum cortisol was measured at 0 minute in all subjects and at 30 and 60 minutes after tetracosactide hexaacetate 250 μg intravenously. Four weeks later, serum cortisol level was measured at 0 minute and at 30 and 60 minutes following 24 units of porcine seq…

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  5. 05HumanNot a test of Cosyntropin aloneNon-randomized trialSafety outcome

    In healthy volunteers, tetracosactide caused no immediate side effects.

    In plain wordsHealthy volunteers had no immediate side effects after tetracosactide.

    Peptide
    Cosyntropin
    Outcome
    Not applicableImmediate side effects
    Study

    n = 15

    Outcome group
    Adverse events · Endocrine and hormones

    Source sentences

    Summary
    There were no immediate side effects in both groups, with a lower cost of procedure in the porcine corticotropin group.
    1 context sentence
    Summary · context
    Fifteen healthy volunteers were enrolled. Serum cortisol was measured at 0 minute in all subjects and at 30 and 60 minutes after tetracosactide hexaacetate 250 μg intravenously. Four weeks later, serum cortisol level was measured at 0 minute and at 30 and 60 minutes following 24 units of porcine seq…

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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