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Study · Non-randomized trial · n = 10 · 2018

3 results

Longitudinal changes in the mismatch field evoked by an empathic voice reflect changes in the empathy quotient in autism spectrum disorder.

Yoshimura Y, Kikuchi M, Hiraishi H, Hasegawa C, Hirosawa T, Takahashi T, Munesue T, Kosaka H, Hiagashida H, Minabe Y

Psychiatry research. Neuroimaging3 Oct 2018Cited by 10 (Europe PMC)

PMID30292077 (opens in a new tab)DOI10.1016/j.pscychresns.2018.05.003 (opens in a new tab)PepBankPUB-30292077
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In adult men with ASD, the MMF amplitude evoked by an empathic voice did not change significantly after the oxytocin administration period.

    In plain wordsIn men with autism, a brain response to an empathic voice did not change significantly after oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeMismatch field (MMF) amplitude in auditory cortex
    Study

    n = 10

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · 8 weeksAs given in this study (human).

    Source sentences

    Summary
    no significant change was observed in the MMF amplitude or EQ score after the administration period of OT
    2 context sentences
    Summary · context
    In the present study, we focused on long-term changes in MMF evoked by an empathic voice and changes in the empathy quotient (EQ) in ASD during an 8-week clinical trial using oxytocin (OT).
    Summary · context
    Ten males with ASD without intellectual disability participated in this pilot study.
  2. 02HumanNon-randomized trialEfficacy outcome

    In adult men with ASD, the empathy quotient score did not change significantly after the oxytocin administration period.

    In plain wordsIn men with autism, empathy scores did not change significantly after oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeEmpathy quotient (EQ) score
    Study

    n = 10

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · 8 weeksAs given in this study (human).

    Source sentences

    Summary
    no significant change was observed in the MMF amplitude or EQ score after the administration period of OT
    2 context sentences
    Summary · context
    In the present study, we focused on long-term changes in MMF evoked by an empathic voice and changes in the empathy quotient (EQ) in ASD during an 8-week clinical trial using oxytocin (OT).
    Summary · context
    Ten males with ASD without intellectual disability participated in this pilot study.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 03HumanNot a test of Oxytocin aloneNon-randomized trialOther

    In adult men with ASD, change in MMF amplitude correlated positively with change in empathy quotient score during the 8-week trial; the authors do not attribute this to oxytocin.

    In plain wordsIn men with autism, changes in a brain response and in empathy scores moved together during the trial. This may not be due to oxytocin.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation between change in MMF amplitude and change in EQ score
    Study

    n = 10

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    a significant positive correlation between the change in the MMF amplitude in the auditory cortex (i.e., right banks of the superior sulcus) and the change in the EQ score during the 8-week clinical trial
    3 context sentences
    Summary · context
    Although we cannot conclude that the observed relationships were caused by OT's effect or by natural changes, our results suggest that MMF evoked by social voice can be a state-dependent marker of empathic abilities in male adults with ASD.
    Summary · context
    In the present study, we focused on long-term changes in MMF evoked by an empathic voice and changes in the empathy quotient (EQ) in ASD during an 8-week clinical trial using oxytocin (OT).
    Summary · context
    Ten males with ASD without intellectual disability participated in this pilot study.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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