Effect of intermittent teriparatide (PTH 1-34) on the alveolar healing process in orchiectomized rats.

de Oliveira D, de Oliveira Puttini I, Silva Gomes-Ferreira PH, Palin LP, Matsumoto MA, Okamoto R

Clinical oral investigations6 Oct 2018Cited by 18 (Europe PMC)

PMID30291494DOI10.1007/s00784-018-2672-yPepBankPUB-30291494

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats after tooth extraction, bone volume fraction did not differ significantly among sham, untreated orchiectomized, and teriparatide-treated orchiectomized groups.
In plain wordsIn rats after tooth extraction, bone volume fraction did not differ significantly between teriparatide-treated animals and sham or untreated groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeBone volume fraction
Study
ratn = 54
Orchiectomized male rats after upper incisor extraction
Comparator
Sham and untreated orchiectomized groups
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
For the BV/TV, Tb.Sp, and Tb.Th parameters, no significant statistical difference was observed among the three experimental groups (p > 0.05).
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty-four male rats were divided into three groups: fictitious surgery (SHAM), bilateral orchiectomy (ORQ NT), and bilateral orchiectomy treated with teriparatide (ORQ TERI).
Summary · context
Right upper incisor extraction was performed.
Summary · context
After 14 and 42 days, the rats were euthanized.
Report a problemFND-3029149406
02AnimalAnimal study (in vivo)Efficacy outcome
In rats after tooth extraction, trabecular separation did not differ significantly among sham, untreated orchiectomized, and teriparatide-treated orchiectomized groups.
In plain wordsIn rats after tooth extraction, trabecular separation did not differ significantly between teriparatide-treated animals and sham or untreated groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeTrabecular separation
Study
ratn = 54
Orchiectomized male rats after upper incisor extraction
Comparator
Sham and untreated orchiectomized groups
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
For the BV/TV, Tb.Sp, and Tb.Th parameters, no significant statistical difference was observed among the three experimental groups (p > 0.05).
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty-four male rats were divided into three groups: fictitious surgery (SHAM), bilateral orchiectomy (ORQ NT), and bilateral orchiectomy treated with teriparatide (ORQ TERI).
Summary · context
Right upper incisor extraction was performed.
Summary · context
After 14 and 42 days, the rats were euthanized.
Report a problemFND-3029149407
03AnimalAnimal study (in vivo)Efficacy outcome
In rats after tooth extraction, trabecular thickness did not differ significantly among sham, untreated orchiectomized, and teriparatide-treated orchiectomized groups.
In plain wordsIn rats after tooth extraction, trabecular thickness did not differ significantly between teriparatide-treated animals and sham or untreated groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeTrabecular thickness
Study
ratn = 54
Orchiectomized male rats after upper incisor extraction
Comparator
Sham and untreated orchiectomized groups
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
For the BV/TV, Tb.Sp, and Tb.Th parameters, no significant statistical difference was observed among the three experimental groups (p > 0.05).
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty-four male rats were divided into three groups: fictitious surgery (SHAM), bilateral orchiectomy (ORQ NT), and bilateral orchiectomy treated with teriparatide (ORQ TERI).
Summary · context
Right upper incisor extraction was performed.
Summary · context
After 14 and 42 days, the rats were euthanized.
Report a problemFND-3029149408
04AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats after tooth extraction, the teriparatide group showed more Wnt labeling.
In plain wordsIn rats with testes removed after tooth extraction, the teriparatide group showed more Wnt labeling than other groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseWnt labeling
Study
ratn: not reported in source
Orchiectomized male rats after upper incisor extraction
Comparator
Other experimental groups
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Days, Wnt, alkaline phosphatase, and osteocalcin revealed more labeling for ORQ TERI and less for TRAP.
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty-four male rats were divided into three groups: fictitious surgery (SHAM), bilateral orchiectomy (ORQ NT), and bilateral orchiectomy treated with teriparatide (ORQ TERI).
Summary · context
Right upper incisor extraction was performed.
Summary · context
After 14 and 42 days, the rats were euthanized.
Report a problemFND-3029149401
05AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats after tooth extraction, the teriparatide group showed more alkaline phosphatase labeling.
In plain wordsIn rats with testes removed after tooth extraction, the teriparatide group showed more alkaline phosphatase labeling than other groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseAlkaline phosphatase labeling
Study
ratn: not reported in source
Orchiectomized male rats after upper incisor extraction
Comparator
Other experimental groups
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Days, Wnt, alkaline phosphatase, and osteocalcin revealed more labeling for ORQ TERI and less for TRAP.
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty-four male rats were divided into three groups: fictitious surgery (SHAM), bilateral orchiectomy (ORQ NT), and bilateral orchiectomy treated with teriparatide (ORQ TERI).
Summary · context
Right upper incisor extraction was performed.
Summary · context
After 14 and 42 days, the rats were euthanized.
Report a problemFND-3029149402
06AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats after tooth extraction, the teriparatide group showed more osteocalcin labeling.
In plain wordsIn rats with testes removed after tooth extraction, the teriparatide group showed more osteocalcin labeling than other groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseOsteocalcin labeling
Study
ratn: not reported in source
Orchiectomized male rats after upper incisor extraction
Comparator
Other experimental groups
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Days, Wnt, alkaline phosphatase, and osteocalcin revealed more labeling for ORQ TERI and less for TRAP.
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty-four male rats were divided into three groups: fictitious surgery (SHAM), bilateral orchiectomy (ORQ NT), and bilateral orchiectomy treated with teriparatide (ORQ TERI).
Summary · context
Right upper incisor extraction was performed.
Summary · context
After 14 and 42 days, the rats were euthanized.
Report a problemFND-3029149403
07AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats after tooth extraction, the teriparatide group showed less TRAP labeling.
In plain wordsIn rats with testes removed after tooth extraction, the teriparatide group showed less TRAP labeling than other groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseTRAP labeling
Study
ratn: not reported in source
Orchiectomized male rats after upper incisor extraction
Comparator
Other experimental groups
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Days, Wnt, alkaline phosphatase, and osteocalcin revealed more labeling for ORQ TERI and less for TRAP.
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty-four male rats were divided into three groups: fictitious surgery (SHAM), bilateral orchiectomy (ORQ NT), and bilateral orchiectomy treated with teriparatide (ORQ TERI).
Summary · context
Right upper incisor extraction was performed.
Summary · context
After 14 and 42 days, the rats were euthanized.
Report a problemFND-3029149404
08AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats after tooth extraction, trabecular number differed significantly between teriparatide-treated and untreated groups; the direction was not reported.
In plain wordsIn rats with testes removed after tooth extraction, trabecular number differed between teriparatide and untreated groups, with no direction reported.
Peptide
Teriparatide (PTH 1-34)
Outcome
Direction not reportedTrabecular number
Study
ratn: not reported in source
Orchiectomized male rats after upper incisor extraction
Comparator
Untreated orchiectomized rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
For the Tb.N in the ORQ NT group was 0.496 mm, a significant statistical difference was observed between the groups of ORQ NT and ORQ TERI (p < 0.05).
3 context sentences(design, population, supporting numbers)
Summary · context
Fifty-four male rats were divided into three groups: fictitious surgery (SHAM), bilateral orchiectomy (ORQ NT), and bilateral orchiectomy treated with teriparatide (ORQ TERI).
Summary · context
Right upper incisor extraction was performed.
Summary · context
After 14 and 42 days, the rats were euthanized.
Report a problemFND-3029149405

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownPhase 4NCT06061354

Teriparatide on Maxillary Sinus Floor Osseointegration

Universidad de Valparaison = 4223 Aug 2023 to est. Dec 2024

Bone Regeneration

Trial page ClinicalTrials.govUpdated 30 Nov 2023

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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