Skip to content

Study · Randomized controlled trial · n = 144 · 2019

2 results

Oxytocin differentially modulates specific dorsal and ventral striatal functional connections with frontal and cerebellar regions.

Zhao Z, Ma X, Geng Y, Zhao W, Zhou F, Wang J, Markett S, Biswal BB, Ma Y, Kendrick KM, Becker B

NeuroImage25 Sept 2018Cited by 53 (Europe PMC)

PMID30266264 (opens in a new tab)DOI10.1016/j.neuroimage.2018.09.067 (opens in a new tab)PepBankPUB-30266264
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy men, oxytocin increased resting-state connectivity between ventral striatal and pallidal nodes and upstream frontal regions versus placebo.

    In plain wordsIn healthy men, oxytocin increased brain connectivity between deep reward areas and frontal regions compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseVentral striatal and pallidal connectivity with frontal regions
    Study

    n = 144

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin specifically increased connectivity between ventral striatal and pallidal nodes with upstream frontal regions
    1 context sentence
    Summary · context
    The present study combined the randomized placebo-controlled administration of oxytocin versus placebo in healthy men (n = 144) with fMRI-based resting-state functional connectivity to determine the modulatory role of oxytocin on the major basal ganglia pathways.
  2. 02HumanRandomized controlled trialMechanism

    In healthy men, oxytocin decreased the strength of pathways between the dorsal striatum and posterior cerebellum versus placebo.

    In plain wordsIn healthy men, oxytocin reduced brain connectivity between the dorsal striatum and the back of the cerebellum compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseDorsal striatum and posterior cerebellum connectivity
    Study

    n = 144

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    it decreased the strengths of downstream pathways between the dorsal striatum and posterior cerebellum.
    1 context sentence
    Summary · context
    The present study combined the randomized placebo-controlled administration of oxytocin versus placebo in healthy men (n = 144) with fMRI-based resting-state functional connectivity to determine the modulatory role of oxytocin on the major basal ganglia pathways.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.