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Study · In vitro (cell-free) · 2018

3 results

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.

Vyunova TV, Andreeva L, Shevchenko K, Myasoedov N

Protein and peptide letters1 Jan 2018Cited by 7 (Europe PMC)

PMID30255741 (opens in a new tab)DOI10.2174/0929866525666180925144642 (opens in a new tab)PepBankPUB-30255741
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Mechanism

    In brain cell membrane preparations, Selank affected [3H]GABA binding as a positive allosteric modulator.

    In plain wordsIn lab tests, Selank changed GABA binding to brain cell membranes by acting as a positive allosteric modulator.

    Peptide
    Selank
    Outcome
    Increase[3H]GABA binding modulation
    Study

    n: not reported in source

    Brain cell plasma membranes (radioligand binding)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was shown that Selank affect the [3H]GABA binding as a positive allosteric modulator.
    1 context sentence
    Summary · context
    The main method we used was the radioligand - receptor method of analysis.
  2. 02LabIn vitro (cell-free)Mechanism

    In brain cell membrane preparations, joint action of Selank and some benzodiazepines regulated [3H]GABA binding in a way that was not cumulative and differed from either substance alone.

    In plain wordsIn lab tests, Selank and some benzodiazepines together affected GABA binding differently from either substance alone, not by simple addition.

    Peptide
    Selank
    Outcome
    Mixed[3H]GABA binding with Selank plus benzodiazepines
    Study

    n: not reported in source

    Brain cell plasma membranes (radioligand binding)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The joint action of Selank and some of benzodiazepines also regulates activity of [3H]GABA binding in specific manner, which is not cumulative and differs from either substance individually.
    1 context sentence
    Summary · context
    The main method we used was the radioligand - receptor method of analysis.
  3. 03LabIn vitro (cell-free)Mechanism

    In brain cell membrane preparations, Selank blocked the modulatory activity of diazepam and olanzapine on [3H]GABA binding.

    In plain wordsIn lab tests, Selank blocked the effect that diazepam and olanzapine have on GABA binding.

    Peptide
    Selank
    Outcome
    Not applicableBlock of diazepam and olanzapine modulation of GABA binding
    Study

    n: not reported in source

    Brain cell plasma membranes (radioligand binding)
    Comparator
    Diazepam; olanzapine
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Selank is able to block the modulatory activity of Diazepam and Olanzapine, the location of their and peptide binding sites apparently not the same, but potentially may partially overlaps.
    1 context sentence
    Summary · context
    The main method we used was the radioligand - receptor method of analysis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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