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Study · Systematic review · 2018

2 results

Intranasal oxytocin and OXTR genotype effects on resting state functional connectivity: A systematic review.

Seeley SH, Chou YH, O'Connor MF

Neuroscience and biobehavioral reviews19 Sept 2018Cited by 42 (Europe PMC)

PMID30243577 (opens in a new tab)DOI10.1016/j.neubiorev.2018.09.011 (opens in a new tab)PepBankPUB-30243577
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanSystematic reviewMechanism

    In a systematic review of human studies, intranasal oxytocin appeared to modulate resting state functional connectivity, similar to its effects on task fMRI.

    In plain wordsA review of human studies found that nasal oxytocin appears to change brain connectivity at rest, much as it does during tasks.

    Peptide
    Oxytocin
    Outcome
    MixedResting state functional connectivity
    Study

    n: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    IN-OT appears to modulate resting state functional connectivity in a manner similar to its effects on task fMRI, consistent with hypothesized models of IN-OT.
    1 context sentence
    Summary · context
    Of 71 unique citations, 18 articles (13 IN-OT, five OXTR) met full inclusion criteria.
  2. 02HumanSystematic reviewOther

    In a systematic review, age, sex, early life stress and psychopathology emerged as potential moderators of intranasal oxytocin effects on resting state connectivity.

    In plain wordsA review of human studies found that age, sex, early life stress and mental health may change how nasal oxytocin affects the brain.

    Peptide
    Oxytocin
    Outcome
    Not applicableModerators of intranasal oxytocin effects on connectivity
    Study

    n: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Age, sex, early life stress, and psychopathology emerged as potential moderators of both IN-OT and OXTR effects.
    1 context sentence
    Summary · context
    Of 71 unique citations, 18 articles (13 IN-OT, five OXTR) met full inclusion criteria.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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