In healthy volunteers, intranasal 1% Semax was linked to a greater volume of the rostral subcomponent of the default mode network on resting state fMRI compared with placebo.
In plain wordsIn healthy adults, a Semax nasal spray was linked to a larger part of a brain network at rest than placebo.
- Peptide
- Semax
- Outcome
- IncreaseDefault mode network rostral (medial frontal cortex) subcomponent volume
- Study
n = 24
- Comparator
- Placebo
- Outcome group
- Brain and neuronal activity · Nervous system and cognition
- Studied dose
- 1% · intranasalAs given in this study (human).
Source sentences
A greater volume of the default mode network rostral (medial frontal cortex) subcomponent was detected in the Semax group in comparison with controls.
2 context sentences(design, population, supporting numbers)
The study was carried out on two groups of healthy volunteers (11 men and 13 women aged 43.9±9.5 years).
Resting state fMRI was carried out 3 times: directly before and 5 and 20 min after intranasal 1% Semax (14 subjects) or placebo (10 subjects).