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Study · Animal study (in vivo) · rat · 2017

7 results

[ANTIINFLAMMATORY AND REGENERATIVE EFFECT OF PEPTIDE THERAPY IN THE MODEL OF OBSTRUCTIVE LUNG PATHOLOGY].

Titova ON, Kuzubova NA, Lebedeva ES, Preobrazhenskaya TN, Surkova EA, Dvorakovskaya IV

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Feb 2017

PMID30199201 (opens in a new tab)PepBankPUB-30199201
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, bronchogen treatment reduced neutrophilic inflammation.

    In plain wordsIn rats with COPD, bronchogen reduced neutrophilic inflammation.

    Peptide
    Bronchogen (AEDL)
    Outcome
    DecreaseNeutrophilic inflammation
    Study

    ratn: not reported in source

    Nitrogen dioxide-induced COPD
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Following the course of peptide treatment the decreased activity of neutrophilic inflammation with the normalization of cellular composition and profile of pro-inflammatory cytokines and enzymes in the bronchoalveolar space was observed.
    1 context sentence
    Summary · context
    The effect of the tetrapeptide bronchogen on the structural and functional state of the bronchial epithelium and inflammatory activity in the lungs was studied in the chronic obstructive pulmonary disease (COPD) model, created in rats by a 60-day intermittent exposure to nitrogen dioxide.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, bronchogen treatment normalized bronchoalveolar cellular composition.

    In plain wordsIn rats with COPD, bronchogen normalized the types of cells in lung lavage fluid.

    Peptide
    Bronchogen (AEDL)
    Outcome
    MixedBALF cellular composition
    Study

    ratn: not reported in source

    Nitrogen dioxide-induced COPD
    Outcome group
    Immune response · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Following the course of peptide treatment the decreased activity of neutrophilic inflammation with the normalization of cellular composition and profile of pro-inflammatory cytokines and enzymes in the bronchoalveolar space was observed.
    1 context sentence
    Summary · context
    The effect of the tetrapeptide bronchogen on the structural and functional state of the bronchial epithelium and inflammatory activity in the lungs was studied in the chronic obstructive pulmonary disease (COPD) model, created in rats by a 60-day intermittent exposure to nitrogen dioxide.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, bronchogen treatment normalized the pro-inflammatory cytokine profile in the bronchoalveolar space.

    In plain wordsIn rats with COPD, bronchogen normalized the inflammatory cytokine profile in lung lavage fluid.

    Peptide
    Bronchogen (AEDL)
    Outcome
    MixedPro-inflammatory cytokine profile
    Study

    ratn: not reported in source

    Nitrogen dioxide-induced COPD
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Following the course of peptide treatment the decreased activity of neutrophilic inflammation with the normalization of cellular composition and profile of pro-inflammatory cytokines and enzymes in the bronchoalveolar space was observed.
    1 context sentence
    Summary · context
    The effect of the tetrapeptide bronchogen on the structural and functional state of the bronchial epithelium and inflammatory activity in the lungs was studied in the chronic obstructive pulmonary disease (COPD) model, created in rats by a 60-day intermittent exposure to nitrogen dioxide.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, bronchogen treatment restored bronchial epithelial structure.

    In plain wordsIn rats with COPD, bronchogen restored the structure of the airway lining.

    Peptide
    Bronchogen (AEDL)
    Outcome
    MixedBronchial epithelial structure
    Study

    ratn: not reported in source

    Nitrogen dioxide-induced COPD
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The structure of bronchial epithelium, disturbed during formation of COPD model, was restored and accompanied by restoration of its functional activity
    1 context sentence
    Summary · context
    The effect of the tetrapeptide bronchogen on the structural and functional state of the bronchial epithelium and inflammatory activity in the lungs was studied in the chronic obstructive pulmonary disease (COPD) model, created in rats by a 60-day intermittent exposure to nitrogen dioxide.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, bronchogen treatment increased secretory immunoglobulin A.

    In plain wordsIn rats with COPD, bronchogen increased secretory immunoglobulin A.

    Peptide
    Bronchogen (AEDL)
    Outcome
    IncreaseSecretory immunoglobulin A
    Study

    ratn: not reported in source

    Nitrogen dioxide-induced COPD
    Outcome group
    Immune response · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    as evidenced by an increase of secretory immunoglobulin A (local immunity marker) and surfactant protein B, responsible for reducing the alveolar surface tension.
    1 context sentence
    Summary · context
    The effect of the tetrapeptide bronchogen on the structural and functional state of the bronchial epithelium and inflammatory activity in the lungs was studied in the chronic obstructive pulmonary disease (COPD) model, created in rats by a 60-day intermittent exposure to nitrogen dioxide.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, bronchogen treatment increased surfactant protein B.

    In plain wordsIn rats with COPD, bronchogen increased surfactant protein B.

    Peptide
    Bronchogen (AEDL)
    Outcome
    IncreaseSurfactant protein B
    Study

    ratn: not reported in source

    Nitrogen dioxide-induced COPD
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    as evidenced by an increase of secretory immunoglobulin A (local immunity marker) and surfactant protein B, responsible for reducing the alveolar surface tension.
    1 context sentence
    Summary · context
    The effect of the tetrapeptide bronchogen on the structural and functional state of the bronchial epithelium and inflammatory activity in the lungs was studied in the chronic obstructive pulmonary disease (COPD) model, created in rats by a 60-day intermittent exposure to nitrogen dioxide.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, bronchogen treatment normalized the enzyme profile in the bronchoalveolar space.

    In plain wordsIn rats with COPD, bronchogen normalized the enzyme profile in lung lavage fluid.

    Peptide
    Bronchogen (AEDL)
    Outcome
    MixedBronchoalveolar enzyme profile
    Study

    ratn: not reported in source

    Nitrogen dioxide-induced COPD
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Following the course of peptide treatment the decreased activity of neutrophilic inflammation with the normalization of cellular composition and profile of pro-inflammatory cytokines and enzymes in the bronchoalveolar space was observed.
    1 context sentence
    Summary · context
    The effect of the tetrapeptide bronchogen on the structural and functional state of the bronchial epithelium and inflammatory activity in the lungs was studied in the chronic obstructive pulmonary disease (COPD) model, created in rats by a 60-day intermittent exposure to nitrogen dioxide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 17:05 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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