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Study · Randomized controlled trial · n = 85 · 2019

2 results

Where is the love? A double-blind, randomized study of the effects of intranasal oxytocin on stress regulation and aggression.

Romney C, Hahn-Holbrook J, Norman GJ, Moore A, Holt-Lunstad J

International journal of psychophysiology : official journal of the International Organization of Psychophysiology23 Aug 2018Cited by 11 (Europe PMC)

PMID30144492 (opens in a new tab)DOI10.1016/j.ijpsycho.2018.08.010 (opens in a new tab)PepBankPUB-30144492
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy adults, intranasal oxytocin significantly raised hostility scores versus placebo, with hostility higher after administration than at baseline only in the oxytocin group.

    In plain wordsIn healthy adults, oxytocin spray raised self-reported hostility compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseSelf-reported hostility
    Study

    n = 85

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    There was a significant difference between the OT and the placebo group on hostility scores (p = 0.03)
    3 context sentences
    Summary · context
    Self-reported hostility was significantly higher at T2 compared to T1 (p < 0.001) among participants in the oxytocin group while no significant change was found in hostility among the placebo group.
    Summary · context
    The present study investigated these competing predictions in the context of a competitive task among 85 healthy human participants (males and females).
    Summary · context
    Using a randomized double-blind design, participants were assigned to an experimental (intranasal OT) or control (intranasal placebo) group.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy adults, behavioral aggression was slightly higher after oxytocin than placebo directly after administration, and the opposite relationship appeared later, with a significant time by group interaction.

    In plain wordsIn healthy adults, aggression was slightly higher with oxytocin spray right after use and then lower than with placebo as time passed.

    Peptide
    Oxytocin
    Outcome
    MixedBehavioral aggression over time
    Study

    n = 85

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    a significant time by group interaction for behavioral aggression (p < 0.05).
    3 context sentences
    Summary · context
    Behavioral aggression was slightly higher in the OT group (compared to the placebo group) directly after OT administration, however, the opposite relationship was found as the study period progressed.
    Summary · context
    The present study investigated these competing predictions in the context of a competitive task among 85 healthy human participants (males and females).
    Summary · context
    Using a randomized double-blind design, participants were assigned to an experimental (intranasal OT) or control (intranasal placebo) group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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