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Study · Animal study (in vivo) · mouse · 2018

8 results

Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome.

Hacohen-Kleiman G, Sragovich S, Karmon G, Gao AYL, Grigg I, Pasmanik-Chor M, Le A, Korenková V, McKinney RA, Gozes I

The Journal of clinical investigation24 Sept 2018Cited by 93 (Europe PMC)

PMID30106381 (opens in a new tab)PMCIDPMC6205398 (opens in a new tab)DOI10.1172/jci98199 (opens in a new tab)PepBankPUB-30106381
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Adnp-deficient mice, NAP partly ameliorated reduced dendritic spine density.

    In plain wordsIn mice with Adnp deficiency, NAP partly improved reduced dendritic spine density.

    Peptide
    Davunetide
    Outcome
    IncreaseDendritic spine density
    Study

    mousen: not reported in source

    Adnp+/- mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We discovered that Adnp deficiency reduced dendritic spine density and altered synaptic gene expression, both of which were partly ameliorated by NAP treatment.
    1 context sentence
    Summary · context
    Here, we established a unique neuronal membrane-tagged, GFP-expressing Adnp+/- mouse line allowing in vivo synaptic pathology quantification.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In Adnp-deficient mice, NAP partly ameliorated altered synaptic gene expression.

    In plain wordsIn mice with Adnp deficiency, NAP partly corrected altered synaptic gene activity.

    Peptide
    Davunetide
    Outcome
    Direction not reportedSynaptic gene expression
    Study

    mousen: not reported in source

    Adnp+/- mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We discovered that Adnp deficiency reduced dendritic spine density and altered synaptic gene expression, both of which were partly ameliorated by NAP treatment.
    1 context sentence
    Summary · context
    Here, we established a unique neuronal membrane-tagged, GFP-expressing Adnp+/- mouse line allowing in vivo synaptic pathology quantification.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Adnp+/- mice, daily NAP partially reversed global developmental delays.

    In plain wordsIn mice with Adnp deficiency, daily NAP partly reduced developmental delays.

    Peptide
    Davunetide
    Outcome
    DecreaseDevelopmental delays
    Study

    mousen: not reported in source

    Adnp+/- mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · systemic/nasalAs given in this study (mouse).

    Source sentences

    Summary
    Adnp+/-mice further exhibited global developmental delays, vocalization impediments, gait and motor dysfunctions, and social and object memory impairments, all of which were partially reversed by daily NAP administration (systemic/nasal).
    1 context sentence
    Summary · context
    Here, we established a unique neuronal membrane-tagged, GFP-expressing Adnp+/- mouse line allowing in vivo synaptic pathology quantification.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In Adnp+/- mice, daily NAP partially reversed vocalization impediments.

    In plain wordsIn mice with Adnp deficiency, daily NAP partly reduced vocalization problems.

    Peptide
    Davunetide
    Outcome
    DecreaseVocalization impediments
    Study

    mousen: not reported in source

    Adnp+/- mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · systemic/nasalAs given in this study (mouse).

    Source sentences

    Summary
    Adnp+/-mice further exhibited global developmental delays, vocalization impediments, gait and motor dysfunctions, and social and object memory impairments, all of which were partially reversed by daily NAP administration (systemic/nasal).
    1 context sentence
    Summary · context
    Here, we established a unique neuronal membrane-tagged, GFP-expressing Adnp+/- mouse line allowing in vivo synaptic pathology quantification.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In Adnp+/- mice, daily NAP partially reversed gait dysfunction.

    In plain wordsIn mice with Adnp deficiency, daily NAP partly reduced walking problems.

    Peptide
    Davunetide
    Outcome
    DecreaseGait dysfunction
    Study

    mousen: not reported in source

    Adnp+/- mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · systemic/nasalAs given in this study (mouse).

    Source sentences

    Summary
    Adnp+/-mice further exhibited global developmental delays, vocalization impediments, gait and motor dysfunctions, and social and object memory impairments, all of which were partially reversed by daily NAP administration (systemic/nasal).
    1 context sentence
    Summary · context
    Here, we established a unique neuronal membrane-tagged, GFP-expressing Adnp+/- mouse line allowing in vivo synaptic pathology quantification.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In Adnp+/- mice, daily NAP partially reversed motor dysfunction.

    In plain wordsIn mice with Adnp deficiency, daily NAP partly reduced movement problems.

    Peptide
    Davunetide
    Outcome
    DecreaseMotor dysfunction
    Study

    mousen: not reported in source

    Adnp+/- mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · systemic/nasalAs given in this study (mouse).

    Source sentences

    Summary
    Adnp+/-mice further exhibited global developmental delays, vocalization impediments, gait and motor dysfunctions, and social and object memory impairments, all of which were partially reversed by daily NAP administration (systemic/nasal).
    1 context sentence
    Summary · context
    Here, we established a unique neuronal membrane-tagged, GFP-expressing Adnp+/- mouse line allowing in vivo synaptic pathology quantification.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In Adnp+/- mice, daily NAP partially reversed social memory impairment.

    In plain wordsIn mice with Adnp deficiency, daily NAP partly reduced social memory problems.

    Peptide
    Davunetide
    Outcome
    DecreaseSocial memory impairment
    Study

    mousen: not reported in source

    Adnp+/- mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · systemic/nasalAs given in this study (mouse).

    Source sentences

    Summary
    Adnp+/-mice further exhibited global developmental delays, vocalization impediments, gait and motor dysfunctions, and social and object memory impairments, all of which were partially reversed by daily NAP administration (systemic/nasal).
    1 context sentence
    Summary · context
    Here, we established a unique neuronal membrane-tagged, GFP-expressing Adnp+/- mouse line allowing in vivo synaptic pathology quantification.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In Adnp+/- mice, daily NAP partially reversed object memory impairment.

    In plain wordsIn mice with Adnp deficiency, daily NAP partly reduced object memory problems.

    Peptide
    Davunetide
    Outcome
    DecreaseObject memory impairment
    Study

    mousen: not reported in source

    Adnp+/- mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · systemic/nasalAs given in this study (mouse).

    Source sentences

    Summary
    Adnp+/-mice further exhibited global developmental delays, vocalization impediments, gait and motor dysfunctions, and social and object memory impairments, all of which were partially reversed by daily NAP administration (systemic/nasal).
    1 context sentence
    Summary · context
    Here, we established a unique neuronal membrane-tagged, GFP-expressing Adnp+/- mouse line allowing in vivo synaptic pathology quantification.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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