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Study · Randomized controlled trial · n = 48 · 2020

5 results

Effects of Intranasal Oxytocin on Stress-Induced Cigarette Craving in Daily Smokers.

Van Hedger K, Bershad AK, Lee R, de Wit H

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco1 Jan 2020Cited by 20 (Europe PMC)

PMID30085292 (opens in a new tab)PMCIDPMC7297012 (opens in a new tab)DOI10.1093/ntr/nty159 (opens in a new tab)PepBankPUB-30085292
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In daily smokers, intranasal oxytocin given before or after a stress task did not alter cigarette craving responses to stress.

    In plain wordsIn daily smokers, oxytocin nasal spray did not change cigarette craving during stress compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeStress-induced cigarette craving
    Study

    n = 48

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    40 IU · intranasal · single dose per sessionAs given in this study (human).

    Source sentences

    Summary
    OT did not alter responses to stress, whether it was administered before or after the stressful task, on measures of cigarette craving, anxiety, heart rate, blood pressure, and cortisol levels.
    1 context sentence
    Summary · context
    Daily smokers (n = 48) completed a stress induction task and a nonstressful control task at two different sessions, receiving intranasal OT (40 IU) or placebo (PBO) before or after the task.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In daily smokers, intranasal oxytocin given before or after a stress task did not alter anxiety responses to stress.

    In plain wordsIn daily smokers, oxytocin nasal spray did not change anxiety during stress compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAnxiety response to stress
    Study

    n = 48

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    40 IU · intranasal · single dose per sessionAs given in this study (human).

    Source sentences

    Summary
    OT did not alter responses to stress, whether it was administered before or after the stressful task, on measures of cigarette craving, anxiety, heart rate, blood pressure, and cortisol levels.
    1 context sentence
    Summary · context
    Daily smokers (n = 48) completed a stress induction task and a nonstressful control task at two different sessions, receiving intranasal OT (40 IU) or placebo (PBO) before or after the task.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In daily smokers, intranasal oxytocin given before or after a stress task did not alter the heart rate response to stress.

    In plain wordsIn daily smokers, oxytocin nasal spray did not change the heart rate response to stress compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeHeart rate response to stress
    Study

    n = 48

    Comparator
    Placebo
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    40 IU · intranasal · single dose per sessionAs given in this study (human).

    Source sentences

    Summary
    OT did not alter responses to stress, whether it was administered before or after the stressful task, on measures of cigarette craving, anxiety, heart rate, blood pressure, and cortisol levels.
    1 context sentence
    Summary · context
    Daily smokers (n = 48) completed a stress induction task and a nonstressful control task at two different sessions, receiving intranasal OT (40 IU) or placebo (PBO) before or after the task.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In daily smokers, intranasal oxytocin given before or after a stress task did not alter the blood pressure response to stress.

    In plain wordsIn daily smokers, oxytocin nasal spray did not change the blood pressure response to stress compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeBlood pressure response to stress
    Study

    n = 48

    Comparator
    Placebo
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    40 IU · intranasal · single dose per sessionAs given in this study (human).

    Source sentences

    Summary
    OT did not alter responses to stress, whether it was administered before or after the stressful task, on measures of cigarette craving, anxiety, heart rate, blood pressure, and cortisol levels.
    1 context sentence
    Summary · context
    Daily smokers (n = 48) completed a stress induction task and a nonstressful control task at two different sessions, receiving intranasal OT (40 IU) or placebo (PBO) before or after the task.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In daily smokers, intranasal oxytocin given before or after a stress task did not alter the cortisol response to stress.

    In plain wordsIn daily smokers, oxytocin nasal spray did not change cortisol levels during stress compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeCortisol response to stress
    Study

    n = 48

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    40 IU · intranasal · single dose per sessionAs given in this study (human).

    Source sentences

    Summary
    OT did not alter responses to stress, whether it was administered before or after the stressful task, on measures of cigarette craving, anxiety, heart rate, blood pressure, and cortisol levels.
    1 context sentence
    Summary · context
    Daily smokers (n = 48) completed a stress induction task and a nonstressful control task at two different sessions, receiving intranasal OT (40 IU) or placebo (PBO) before or after the task.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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