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Study · Randomized controlled trial · n = 16 · 2018

2 results

Effects of oxytocin on working memory and executive control system connectivity in posttraumatic stress disorder.

Flanagan JC, Hand A, Jarnecke AM, Moran-Santa Maria MM, Brady KT, Joseph JE

Experimental and clinical psychopharmacology1 Aug 2018Cited by 39 (Europe PMC)

PMID30070567 (opens in a new tab)PMCIDPMC6075739 (opens in a new tab)DOI10.1037/pha0000197 (opens in a new tab)PepBankPUB-30070567
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with PTSD, oxytocin (24 IU) improved performance in the 2-back condition of the n-back task compared with placebo.

    In plain wordsIn people with PTSD, oxytocin improved working memory task performance more than placebo.

    Peptide
    Oxytocin
    Outcome
    Increase2-back working memory performance
    Study

    n = 16

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IUAs given in this study (human).

    Source sentences

    Summary
    Results indicate that individuals with PTSD on oxytocin performed better in the 2-back condition of the n-back task compared with individuals with PTSD on placebo.
    1 context sentence
    Summary · context
    Using a double-blind, placebo-controlled design, this study employed functional MRI (fMRI) and the n-back working memory task to examine the effects of oxytocin (24 IU) versus placebo on working memory and dorsolateral prefrontal cortex (DLPFC) connectivity among individuals with PTSD (n = 16) as co…
  2. 02HumanRandomized controlled trialMechanism

    In adults with PTSD, oxytocin increased connectivity between the dorsolateral prefrontal cortex and the anterior cingulate in the 2-back condition compared with placebo.

    In plain wordsIn people with PTSD, oxytocin increased brain connectivity between two regions during a memory task, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseDLPFC-anterior cingulate connectivity in the 2-back condition
    Study

    n = 16

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IUAs given in this study (human).

    Source sentences

    Summary
    Results also indicate that connectivity between DLPFC and anterior cingulate increased in the 2-back condition among individuals with PTSD on oxytocin as compared with placebo.
    1 context sentence
    Summary · context
    Using a double-blind, placebo-controlled design, this study employed functional MRI (fMRI) and the n-back working memory task to examine the effects of oxytocin (24 IU) versus placebo on working memory and dorsolateral prefrontal cortex (DLPFC) connectivity among individuals with PTSD (n = 16) as co…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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