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Study · In silico · 2018

2 results

Deciphering cellular biological processes to clinical application: a new perspective for Tα1 treatment targeting multiple diseases.

Matteucci C, Argaw-Denboba A, Balestrieri E, Giovinazzo A, Miele M, D'Agostini C, Pica F, Grelli S, Paci M, Mastino A, Sinibaldi Vallebona P, Garaci E, Tomino C

Expert opinion on biological therapy1 Jul 2018Cited by 15 (Europe PMC)

PMID30063863 (opens in a new tab)DOI10.1080/14712598.2018.1474198 (opens in a new tab)PepBankPUB-30063863
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01Computer modelIn silicoMechanism

    Network enrichment analysis of PBMC transcriptional data predicted that Tα1 regulates immune and metabolic responses, oxidative stress, ion homeostasis, peroxisome biogenesis and drug metabolic process.

    In plain wordsA computer analysis of immune cell gene data predicted that thymosin alpha‑1 affects immune and metabolic processes and stress responses.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableBiological processes regulated by Tα1
    Study

    humann: not reported in source

    PBMC transcriptional profile after in vitro Tα1 treatment
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Networked cellular responses reflected Tα1 regulated biological processes including immune and metabolic responses, response to compounds and oxidative stress, ion homeostasis, peroxisome biogenesis and drug metabolic process.
    1 context sentence
    Summary · context
    We used the transcriptional profile of human peripheral blood mononuclear cells treated in vitro with Tα1 to perform the enrichment network analysis by the Metascape online tools and the disease enrichment analysis by the DAVID online tool.
  2. 02Computer modelIn silicoOther

    Disease enrichment analysis associated the Tα1-induced cellular network with kidney chronic failure, diabetes, cardiovascular, chronic respiratory, neuropsychiatric, neurodegenerative and autoimmune diseases.

    In plain wordsA computer analysis linked the gene changes from thymosin alpha‑1 to several diseases. This is a prediction, not a clinical test.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableDisease associations of Tα1-regulated networks
    Study

    humann: not reported in source

    PBMC transcriptional profile after in vitro Tα1 treatment
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Beyond cancer and infections, the analysis evidenced the association with disorders such as kidney chronic failure, diabetes, cardiovascular, chronic respiratory, neuropsychiatric, neurodegenerative and autoimmune diseases.
    1 context sentence
    Summary · context
    We used the transcriptional profile of human peripheral blood mononuclear cells treated in vitro with Tα1 to perform the enrichment network analysis by the Metascape online tools and the disease enrichment analysis by the DAVID online tool.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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