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Study · Non-randomized trial · n = 156 · 2018

4 results

Oxytocin Administration in High-Intensity Focused Ultrasound Treatment of Myomata.

Lozinski T, Filipowska J, Krol P, Kubaty A, Wegrzyn P

BioMed research international2 Jul 2018Cited by 18 (Europe PMC)

PMID30057909 (opens in a new tab)PMCIDPMC6051281 (opens in a new tab)DOI10.1155/2018/7518026 (opens in a new tab)PepBankPUB-30057909
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Summary

ObjectivesThe aim of the study was to evaluate the clinical efficacy of magnetic resonance-guided High-Intensity Focused Ultrasound (HIFU) in patients with symptomatic uterine fibroids (myomata) after application of oxytocin.Methods156 women with symptomatic uterine fibroids were treated using MR-guided HIFU procedure. 51 patients had additional IV administration of 40 IU of oxytocin in 5% Glucose or 0,9% NaCl solution during therapy. Before and after the procedure we performed MR and measured initial perfused volume, final perfused volume, nonperfused volume (NPV), and treated volume ratio (TVR). The follow-up was up to 15 months to assess efficacy of treatment and relief of symptoms.ResultsNonperfused volume was statistically significantly larger in oxytocin group than in control group (p=0.0019). The remaining parameters did not show significant difference between both groups.ConclusionOxytocin administration seems to improve efficiency of HIFU therapy although further research is required to assess its value. This study' clinical registration number is DRKS00014794.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In women with symptomatic uterine fibroids treated with HIFU, adding intravenous oxytocin gave a significantly larger nonperfused volume than HIFU alone.

    In plain wordsIn women with fibroids, oxytocin given during ultrasound treatment led to a larger treated area than ultrasound treatment alone.

    Peptide
    Oxytocin
    Outcome
    IncreaseNonperfused volume (NPV)
    Study

    n = 156

    Comparator
    HIFU alone (control group)
    Outcome group
    Tumor growth · Reproductive and sexual health
    Studied dose
    40 IU · intravenous · during HIFU therapyAs given in this study (human).

    Source sentences

    Summary
    Nonperfused volume was statistically significantly larger in oxytocin group than in control group (p=0.0019).
    1 context sentence
    Summary · context
    156 women with symptomatic uterine fibroids were treated using MR-guided HIFU procedure. 51 patients had additional IV administration of 40 IU of oxytocin in 5% Glucose or 0,9% NaCl solution during therapy.
  2. 02HumanNon-randomized trialEfficacy outcome

    In women with symptomatic uterine fibroids treated with HIFU, adding intravenous oxytocin did not significantly change initial perfused volume versus HIFU alone.

    In plain wordsIn women with fibroids, oxytocin during ultrasound treatment did not change initial perfused volume compared with ultrasound treatment alone.

    Peptide
    Oxytocin
    Outcome
    No significant changeInitial perfused volume
    Study

    n = 156

    Comparator
    HIFU alone (control group)
    Outcome group
    Tumor growth · Reproductive and sexual health
    Studied dose
    40 IU · intravenous · during HIFU therapyAs given in this study (human).

    Source sentences

    Summary
    The remaining parameters did not show significant difference between both groups.
    2 context sentences
    Summary · context
    measured initial perfused volume, final perfused volume, nonperfused volume (NPV), and treated volume ratio (TVR)
    Summary · context
    156 women with symptomatic uterine fibroids were treated using MR-guided HIFU procedure. 51 patients had additional IV administration of 40 IU of oxytocin in 5% Glucose or 0,9% NaCl solution during therapy.
  3. 03HumanNon-randomized trialEfficacy outcome

    In women with symptomatic uterine fibroids treated with HIFU, adding intravenous oxytocin did not significantly change final perfused volume versus HIFU alone.

    In plain wordsIn women with fibroids, oxytocin during ultrasound treatment did not change final perfused volume compared with ultrasound treatment alone.

    Peptide
    Oxytocin
    Outcome
    No significant changeFinal perfused volume
    Study

    n = 156

    Comparator
    HIFU alone (control group)
    Outcome group
    Tumor growth · Reproductive and sexual health
    Studied dose
    40 IU · intravenous · during HIFU therapyAs given in this study (human).

    Source sentences

    Summary
    The remaining parameters did not show significant difference between both groups.
    2 context sentences
    Summary · context
    measured initial perfused volume, final perfused volume, nonperfused volume (NPV), and treated volume ratio (TVR)
    Summary · context
    156 women with symptomatic uterine fibroids were treated using MR-guided HIFU procedure. 51 patients had additional IV administration of 40 IU of oxytocin in 5% Glucose or 0,9% NaCl solution during therapy.
  4. 04HumanNon-randomized trialEfficacy outcome

    In women with symptomatic uterine fibroids treated with HIFU, adding intravenous oxytocin did not significantly change the treated volume ratio versus HIFU alone.

    In plain wordsIn women with fibroids, oxytocin during ultrasound treatment did not change the treated volume ratio compared with ultrasound treatment alone.

    Peptide
    Oxytocin
    Outcome
    No significant changeTreated volume ratio (TVR)
    Study

    n = 156

    Comparator
    HIFU alone (control group)
    Outcome group
    Tumor growth · Reproductive and sexual health
    Studied dose
    40 IU · intravenous · during HIFU therapyAs given in this study (human).

    Source sentences

    Summary
    The remaining parameters did not show significant difference between both groups.
    2 context sentences
    Summary · context
    measured initial perfused volume, final perfused volume, nonperfused volume (NPV), and treated volume ratio (TVR)
    Summary · context
    156 women with symptomatic uterine fibroids were treated using MR-guided HIFU procedure. 51 patients had additional IV administration of 40 IU of oxytocin in 5% Glucose or 0,9% NaCl solution during therapy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

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