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Study · Case report or series · n = 5 · 2018

3 results

Evaluation of growth hormone-releasing peptide-2 for diagnosis of thyrotropin-producing pituitary adenomas.

Kageyama K, Sakihara S, Kameda W, Sugiyama A, Takayasu S, Terui K, Daimon M

Endocrine journal5 Jul 2018Cited by 1 (Europe PMC)

PMID29973439 (opens in a new tab)DOI10.1507/endocrj.ej17-0527 (opens in a new tab)PepBankPUB-29973439
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanCase report or seriesActivity measurement

    In 5 patients with TSH-producing adenoma, 2 (40%) had a significant serum TSH response to GHRP‑2, defined as an increase above 50% over baseline.

    In plain wordsIn 2 of 5 patients with TSH-producing pituitary tumours, GHRP‑2 clearly raised TSH.

    Peptide
    GHRP-2
    Outcome
    IncreaseTSH response to GHRP-2 test
    Study

    n = 5

    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Of 5 patients, 2 (40%) showed such a significant response, defined as a >50% increase in serum TSH level above baseline in the GHRP-2 test.
    1 context sentence
    Summary · context
    A total of 5 patients (4 women and 1 man) referred to our departments for further evaluation of pituitary hormones were followed-up using the GHRP-2, TSH-releasing hormone (TRH), octreotide, and bromocriptine tests to examine and evaluate TSH secretory dynamics in TSH-producing adenomas.
  2. 02HumanCase report or seriesActivity measurement

    One further patient showed a 48% increase in serum TSH level after GHRP‑2.

    In plain wordsOne more patient had a TSH rise of 48% after GHRP‑2, just under the cut-off.

    Peptide
    GHRP-2
    Outcome
    IncreaseTSH increase in one additional patient
    Study

    n = 1

    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, 1 patient showed a 48% increase in serum TSH level.
    1 context sentence
    Summary · context
    A total of 5 patients (4 women and 1 man) referred to our departments for further evaluation of pituitary hormones were followed-up using the GHRP-2, TSH-releasing hormone (TRH), octreotide, and bromocriptine tests to examine and evaluate TSH secretory dynamics in TSH-producing adenomas.
  3. 03HumanCase report or seriesActivity measurement

    In one patient whose adenoma was completely removed, serum TSH failed to increase in response to GHRP‑2 after the operation.

    In plain wordsIn a patient whose tumour was removed, GHRP‑2 no longer raised TSH.

    Peptide
    GHRP-2
    Outcome
    No significant changeTSH response after complete adenoma removal
    Study

    n = 1

    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In 1 patient whose adenoma was completely removed, basal serum concentrations of TSH were sufficiently suppressed after the operation, and serum TSH levels failed to increase in response to GHRP-2 administration.
    1 context sentence
    Summary · context
    A total of 5 patients (4 women and 1 man) referred to our departments for further evaluation of pituitary hormones were followed-up using the GHRP-2, TSH-releasing hormone (TRH), octreotide, and bromocriptine tests to examine and evaluate TSH secretory dynamics in TSH-producing adenomas.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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