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Study · Non-randomized trial · n = 20 · 2018

3 results

[Anti-inflammatory effects of neurotrophic therapy (a pilot study)].

Malashenkova IK, Krynskiy SA, Hailov NA, Ogurtsov DP, Selezneva ND, Fedorova YB, Ponomareva EV, Kolyhalov IV, Gavrilova SI, Didkovsky NA

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2018Cited by 7 (Europe PMC)

PMID29927402 (opens in a new tab)DOI10.17116/jnevro20181185139 (opens in a new tab)PepBankPUB-29927402
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In patients with mild cognitive impairment, clinical improvement appeared 6 and/or 22 weeks after Cerebrolysin treatment.

    In plain wordsIn patients with mild cognitive impairment, clinical improvement appeared 6 and/or 22 weeks after Cerebrolysin treatment.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseClinical improvement
    Study

    n = 20

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intravenous · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    An improvement was seen 6 and/or 22 weeks after treatment.
    2 context sentences
    Summary · context
    Twenty patients with MCI were treated with cerebrolysin administered intravenously during 4 weeks.
    Summary · context
    Serum levels of immunoglobulins, inflammatory markers, neurotrophic factors were measured in dynamics in patients and controls using ELISA.
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients with mild cognitive impairment, the study identified four response types after Cerebrolysin treatment, including no effect.

    In plain wordsIn patients with mild cognitive impairment, the study identified four response types after Cerebrolysin treatment, including no effect.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableResponse patterns
    Study

    n = 20

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intravenous · 4 weeksAs given in this study (human).

    Measurements

    Number of response types
    4 types
    Response to neurotrophic treatment, including no effect

    Source sentences

    Summary
    Four types of response to neurotrophic treatment (fast long-term, fast short-term, delayed long-term), without effect were determined, the longer duration of positive effect of cerebrolysin was shown.
    2 context sentences
    Summary · context
    Twenty patients with MCI were treated with cerebrolysin administered intravenously during 4 weeks.
    Summary · context
    Serum levels of immunoglobulins, inflammatory markers, neurotrophic factors were measured in dynamics in patients and controls using ELISA.
  3. 03HumanNon-randomized trialMechanism

    In patients with mild cognitive impairment given Cerebrolysin, humoral immunity indices, clinical blood test results, cortisol and neurotrophin levels assessed before and after treatment differed between patients with and without a positive effect.

    In plain wordsIn patients with mild cognitive impairment given Cerebrolysin, immunity measures, blood tests, cortisol and neurotrophin levels differed between those with and without a positive effect.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedImmunity, blood test, cortisol and neurotrophin differences between responders and nonresponders
    Study

    n: not reported in source

    Comparator
    Patients without positive effect
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · intravenous · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    There were differences in the indices of humoral immunity, clinical blood test results, cortisol and neurotrophin levels assessed before and after treatment between the patients with- and without positive effect of cerebrolysin.
    2 context sentences
    Summary · context
    Twenty patients with MCI were treated with cerebrolysin administered intravenously during 4 weeks.
    Summary · context
    Serum levels of immunoglobulins, inflammatory markers, neurotrophic factors were measured in dynamics in patients and controls using ELISA.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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