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Study · Non-randomized trial · n = 110 · 2018

3 results

[The efficacy of semax in the tretament of patients at different stages of ischemic stroke].

Gusev EI, Martynov MY, Kostenko EV, Petrova LV, Bobyreva SN

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2018Cited by 16 (Europe PMC)

PMID29798983 (opens in a new tab)DOI10.17116/jnevro20181183261-68 (opens in a new tab)PepBankPUB-29798983
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialMechanism

    In adults after ischemic stroke, semax administration increased plasma BDNF levels regardless of the timing of rehabilitation, and the levels stayed high during the whole study period.

    In plain wordsIn people after stroke, semax raised blood levels of BDNF, a nerve growth protein, and the levels stayed high during the study.

    Peptide
    Semax
    Outcome
    IncreasePlasma BDNF level
    Study

    n = 110

    Comparator
    Patients without semax (semax- subgroups)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    6000 mcg/day, 2 courses · 2 courses of 10 days with a 20-day intervalAs given in this study (human).

    Source sentences

    Summary
    Administration of semax, regardless of the timing of rehabilitation, increased BDNF plasma levels which remained high during the whole study period.
    3 context sentences
    Summary · context
    One hundred and ten patients after IS (43 men, 67 women, mean age 58.0±9.7, Ме 63 years) were examined.
    Summary · context
    Each group was subdivided into semax+ and semax- subgroups.
    Summary · context
    Standard regimen of semax included 2 courses (6000 mcg/day) for 10 days with 20 day interval.
  2. 02HumanNon-randomized trialEfficacy outcome

    In adults after ischemic stroke, semax administration and high BDNF levels accelerated improvement of the Barthel index score.

    In plain wordsIn people after stroke, semax and high BDNF levels were linked to faster gains in daily living ability.

    Peptide
    Semax
    Outcome
    IncreaseSpeed of Barthel index improvement
    Study

    n = 110

    Comparator
    Patients without semax (semax- subgroups)
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    6000 mcg/day, 2 courses · 2 courses of 10 days with a 20-day intervalAs given in this study (human).

    Source sentences

    Summary
    Administration of semax and high BDNF levels accelerated the improvement and ameliorated the final outcome of Barthel score index.
    3 context sentences
    Summary · context
    One hundred and ten patients after IS (43 men, 67 women, mean age 58.0±9.7, Ме 63 years) were examined.
    Summary · context
    Each group was subdivided into semax+ and semax- subgroups.
    Summary · context
    Standard regimen of semax included 2 courses (6000 mcg/day) for 10 days with 20 day interval.
  3. 03HumanNon-randomized trialEfficacy outcome

    In adults after ischemic stroke, semax administration and high BDNF levels ameliorated the final outcome of the Barthel score index.

    In plain wordsIn people after stroke, semax and high BDNF levels were linked to a better final daily living score.

    Peptide
    Semax
    Outcome
    IncreaseFinal Barthel index score
    Study

    n = 110

    Comparator
    Patients without semax (semax- subgroups)
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    6000 mcg/day, 2 courses · 2 courses of 10 days with a 20-day intervalAs given in this study (human).

    Source sentences

    Summary
    Administration of semax and high BDNF levels accelerated the improvement and ameliorated the final outcome of Barthel score index.
    3 context sentences
    Summary · context
    One hundred and ten patients after IS (43 men, 67 women, mean age 58.0±9.7, Ме 63 years) were examined.
    Summary · context
    Each group was subdivided into semax+ and semax- subgroups.
    Summary · context
    Standard regimen of semax included 2 courses (6000 mcg/day) for 10 days with 20 day interval.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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