In human primary monocytes, LR12 partly prevented LPS-induced activation compared with LPS without LR12.
In plain wordsIn cells, LR12 partly prevented monocyte activation compared with LPS without LR12.
- Peptide
- Nangibotide
- Outcome
- DecreaseMonocyte activation
- Study
humann: not reported in source
Primary monocytes stimulated with P. gingivalis LPS- Comparator
- LPS without LR12
- Outcome group
- Immune response · Immune and inflammation
- Studied dose
- Dose not stated
Source sentences
This monocytes' activation was partly prevented by LR12.
2 context sentences(design, population, supporting numbers)
P. gingivalis LPS can induce a significant increase in TREM-1 expression (mRNA, membrane-bound and soluble form, p < 0.001) as well as cytokines (IL-1β, TNFα) and chemokines (IL-8) production by monocytes.
To investigate the role of P. gingivalis lipopolysaccharide (LPS) and the effect of LR12, a TREM-1 inhibitory peptide, on the expression of membrane-bound and soluble form of TREM-1 on human primary monocytes, as well as the production of proinflammatory cytokines.Material and methodsCells…