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Study · Animal study (in vivo) · rat · 2018

8 results

Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats.

Mahmoudi J, Mohaddes G, Erfani M, Sadigh-Eteghad S, Karimi P, Rajabi M, Reyhani-Rad S, Farajdokht F

Brain research bulletin9 May 2018Cited by 33 (Europe PMC)

PMID29752991 (opens in a new tab)DOI10.1016/j.brainresbull.2018.05.008 (opens in a new tab)PepBankPUB-29752991
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with nitroglycerin-induced migraine, Cerebrolysin reduced mechanical hyperalgesia.

    In plain wordsIn rats with nitroglycerin-induced migraine, Cerebrolysin reduced mechanical hyperalgesia.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseMechanical hyperalgesia
    Study

    ratn: not reported in source

    Nitroglycerin-induced migraine
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    2.5 and 5 ml/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    whereas CBL treatment markedly reduced mechanical and thermal hyperalgesia, head grooming, and light-aversive behaviors induced by NTG.
    3 context sentences
    Summary · context
    Experiments were carried out on 8 weeks, male Wistar rats.
    Summary · context
    Chronic migraine was modeled by injection (10 mg/kg, i.p) of nitroglycerin (NTG) on days 3, 5, 7, and 9.
    Summary · context
    CBL (2.5 and 5 ml/kg, i.p.) was injected every day for 10 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with nitroglycerin-induced migraine, Cerebrolysin reduced thermal hyperalgesia.

    In plain wordsIn rats with nitroglycerin-induced migraine, Cerebrolysin reduced thermal hyperalgesia.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseThermal hyperalgesia
    Study

    ratn: not reported in source

    Nitroglycerin-induced migraine
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    2.5 and 5 ml/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    whereas CBL treatment markedly reduced mechanical and thermal hyperalgesia, head grooming, and light-aversive behaviors induced by NTG.
    3 context sentences
    Summary · context
    Experiments were carried out on 8 weeks, male Wistar rats.
    Summary · context
    Chronic migraine was modeled by injection (10 mg/kg, i.p) of nitroglycerin (NTG) on days 3, 5, 7, and 9.
    Summary · context
    CBL (2.5 and 5 ml/kg, i.p.) was injected every day for 10 days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with nitroglycerin-induced migraine, Cerebrolysin reduced head grooming.

    In plain wordsIn rats with nitroglycerin-induced migraine, Cerebrolysin reduced head grooming.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseHead grooming
    Study

    ratn: not reported in source

    Nitroglycerin-induced migraine
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    2.5 and 5 ml/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    whereas CBL treatment markedly reduced mechanical and thermal hyperalgesia, head grooming, and light-aversive behaviors induced by NTG.
    3 context sentences
    Summary · context
    Experiments were carried out on 8 weeks, male Wistar rats.
    Summary · context
    Chronic migraine was modeled by injection (10 mg/kg, i.p) of nitroglycerin (NTG) on days 3, 5, 7, and 9.
    Summary · context
    CBL (2.5 and 5 ml/kg, i.p.) was injected every day for 10 days.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with nitroglycerin-induced migraine, Cerebrolysin reduced light-aversive behaviors.

    In plain wordsIn rats with nitroglycerin-induced migraine, Cerebrolysin reduced light-aversive behaviors.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseLight-aversive behaviors
    Study

    ratn: not reported in source

    Nitroglycerin-induced migraine
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    2.5 and 5 ml/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    whereas CBL treatment markedly reduced mechanical and thermal hyperalgesia, head grooming, and light-aversive behaviors induced by NTG.
    3 context sentences
    Summary · context
    Experiments were carried out on 8 weeks, male Wistar rats.
    Summary · context
    Chronic migraine was modeled by injection (10 mg/kg, i.p) of nitroglycerin (NTG) on days 3, 5, 7, and 9.
    Summary · context
    CBL (2.5 and 5 ml/kg, i.p.) was injected every day for 10 days.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with migraine, Cerebrolysin significantly reduced blood CGRP levels.

    In plain wordsIn rats with migraine, Cerebrolysin reduced blood CGRP levels.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBlood CGRP
    Study

    ratn: not reported in source

    Nitroglycerin-induced migraine
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 and 5 ml/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    Also, blood levels of CGRP, PACAP, and pro-inflammatory cytokines (TNF-α and IL-1β) significantly decreased by CBL administration.
    3 context sentences
    Summary · context
    Experiments were carried out on 8 weeks, male Wistar rats.
    Summary · context
    Chronic migraine was modeled by injection (10 mg/kg, i.p) of nitroglycerin (NTG) on days 3, 5, 7, and 9.
    Summary · context
    CBL (2.5 and 5 ml/kg, i.p.) was injected every day for 10 days.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with migraine, Cerebrolysin significantly reduced blood PACAP levels.

    In plain wordsIn rats with migraine, Cerebrolysin reduced blood PACAP levels.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBlood PACAP
    Study

    ratn: not reported in source

    Nitroglycerin-induced migraine
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 and 5 ml/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    Also, blood levels of CGRP, PACAP, and pro-inflammatory cytokines (TNF-α and IL-1β) significantly decreased by CBL administration.
    3 context sentences
    Summary · context
    Experiments were carried out on 8 weeks, male Wistar rats.
    Summary · context
    Chronic migraine was modeled by injection (10 mg/kg, i.p) of nitroglycerin (NTG) on days 3, 5, 7, and 9.
    Summary · context
    CBL (2.5 and 5 ml/kg, i.p.) was injected every day for 10 days.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with migraine, Cerebrolysin significantly reduced blood TNF-α levels.

    In plain wordsIn rats with migraine, Cerebrolysin reduced blood TNF-α levels.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBlood TNF-α
    Study

    ratn: not reported in source

    Nitroglycerin-induced migraine
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    2.5 and 5 ml/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    Also, blood levels of CGRP, PACAP, and pro-inflammatory cytokines (TNF-α and IL-1β) significantly decreased by CBL administration.
    3 context sentences
    Summary · context
    Experiments were carried out on 8 weeks, male Wistar rats.
    Summary · context
    Chronic migraine was modeled by injection (10 mg/kg, i.p) of nitroglycerin (NTG) on days 3, 5, 7, and 9.
    Summary · context
    CBL (2.5 and 5 ml/kg, i.p.) was injected every day for 10 days.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with migraine, Cerebrolysin significantly reduced blood IL-1β levels.

    In plain wordsIn rats with migraine, Cerebrolysin reduced blood IL-1β levels.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBlood IL-1β
    Study

    ratn: not reported in source

    Nitroglycerin-induced migraine
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    2.5 and 5 ml/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    Also, blood levels of CGRP, PACAP, and pro-inflammatory cytokines (TNF-α and IL-1β) significantly decreased by CBL administration.
    3 context sentences
    Summary · context
    Experiments were carried out on 8 weeks, male Wistar rats.
    Summary · context
    Chronic migraine was modeled by injection (10 mg/kg, i.p) of nitroglycerin (NTG) on days 3, 5, 7, and 9.
    Summary · context
    CBL (2.5 and 5 ml/kg, i.p.) was injected every day for 10 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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