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Study · Not a test of the peptide alone · 2018

9 results

Gene cloning, expression and immune adjuvant properties of the recombinant fusion peptide Tα1-BLP on avian influenza inactivate virus vaccine.

Zhang C, Zhou J, Cai K, Zhang W, Liao C, Wang C

Microbial pathogenesis3 May 2018Cited by 2 (Europe PMC)

PMID29730515 (opens in a new tab)DOI10.1016/j.micpath.2018.05.003 (opens in a new tab)PepBankPUB-29730515
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone9

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    In chickens immunized with H9N2 inactivated virus plus the Tα1-BLP fusion peptide, HI antibody titers were enhanced.

    In plain wordsIn chickens, a vaccine given with a thymosin alpha‑1 fusion peptide raised antibody levels.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseHI antibody titers
    Study

    chickenn: not reported in source

    H9N2 avian influenza WIV vaccination model
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Tα1-BLP enhanced HI antibody and antigen-specific IgG antibodies titers
    1 context sentence
    Summary · context
    To evaluate the immune adjuvant properties of Tα1-BLP, chickens were immunized with Tα1-BLP combined with H9N2 avian influenza whole-inactivated virus (WIV).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    In chickens immunized with H9N2 inactivated virus plus the Tα1-BLP fusion peptide, antigen-specific IgG titers were enhanced.

    In plain wordsIn chickens, a vaccine given with a thymosin alpha‑1 fusion peptide raised virus-specific IgG antibody levels.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAntigen-specific IgG antibody titers
    Study

    chickenn: not reported in source

    H9N2 avian influenza WIV vaccination model
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Tα1-BLP enhanced HI antibody and antigen-specific IgG antibodies titers
    1 context sentence
    Summary · context
    To evaluate the immune adjuvant properties of Tα1-BLP, chickens were immunized with Tα1-BLP combined with H9N2 avian influenza whole-inactivated virus (WIV).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 03AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    In chickens immunized with H9N2 inactivated virus plus the Tα1-BLP fusion peptide, the level of virus-neutralizing antibodies increased.

    In plain wordsIn chickens, a vaccine given with a thymosin alpha‑1 fusion peptide raised levels of antibodies that neutralize the virus.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAIV-neutralizing antibodies
    Study

    chickenn: not reported in source

    H9N2 avian influenza WIV vaccination model
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    increased the level of AIV-neutralizing antibodies
    1 context sentence
    Summary · context
    To evaluate the immune adjuvant properties of Tα1-BLP, chickens were immunized with Tα1-BLP combined with H9N2 avian influenza whole-inactivated virus (WIV).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  4. 04AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Mechanism

    In chickens immunized with H9N2 inactivated virus plus the Tα1-BLP fusion peptide, Th1-type cytokine secretion was induced.

    In plain wordsIn chickens, a vaccine given with a thymosin alpha‑1 fusion peptide increased Th1-type immune signalling molecules.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseTh1-type cytokine secretion
    Study

    chickenn: not reported in source

    H9N2 avian influenza WIV vaccination model
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    induced the secretion of Th1- and Th2-type cytokines
    2 context sentences
    Summary · context
    The titers of HI antibody, antigen-specific antibodies, AIV-neutralizing antibodies, levels of Th1-type cytokines (IFN-γ) and Th2-type cytokines (IL-4) and lymphocyte proliferation responses were determined.
    Summary · context
    To evaluate the immune adjuvant properties of Tα1-BLP, chickens were immunized with Tα1-BLP combined with H9N2 avian influenza whole-inactivated virus (WIV).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  5. 05AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Mechanism

    In chickens immunized with H9N2 inactivated virus plus the Tα1-BLP fusion peptide, Th2-type cytokine secretion was induced.

    In plain wordsIn chickens, a vaccine given with a thymosin alpha‑1 fusion peptide increased Th2-type immune signalling molecules.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseTh2-type cytokine secretion
    Study

    chickenn: not reported in source

    H9N2 avian influenza WIV vaccination model
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    induced the secretion of Th1- and Th2-type cytokines
    2 context sentences
    Summary · context
    The titers of HI antibody, antigen-specific antibodies, AIV-neutralizing antibodies, levels of Th1-type cytokines (IFN-γ) and Th2-type cytokines (IL-4) and lymphocyte proliferation responses were determined.
    Summary · context
    To evaluate the immune adjuvant properties of Tα1-BLP, chickens were immunized with Tα1-BLP combined with H9N2 avian influenza whole-inactivated virus (WIV).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  6. 06AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Mechanism

    In chickens immunized with H9N2 inactivated virus plus the Tα1-BLP fusion peptide, T and B lymphocyte proliferation was promoted.

    In plain wordsIn chickens, a vaccine given with a thymosin alpha‑1 fusion peptide increased the growth of immune cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseT and B lymphocyte proliferation
    Study

    chickenn: not reported in source

    H9N2 avian influenza WIV vaccination model
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    promoted the proliferation of T and B lymphocyte, Furthermore, virus challenge experiment and HE staining confirmed that Tα1-BLP contributed to inhibition replication of the virus from chicken lungs and protected the lungs from damage.
    1 context sentence
    Summary · context
    To evaluate the immune adjuvant properties of Tα1-BLP, chickens were immunized with Tα1-BLP combined with H9N2 avian influenza whole-inactivated virus (WIV).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  7. 07AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    In chickens immunized with H9N2 inactivated virus plus the Tα1-BLP fusion peptide, virus replication in the lungs was inhibited after challenge.

    In plain wordsIn chickens, a vaccine given with a thymosin alpha‑1 fusion peptide reduced virus growth in the lungs after exposure.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseViral replication in chicken lungs after challenge
    Study

    chickenn: not reported in source

    H9N2 avian influenza WIV vaccination model
    Outcome group
    Antiviral activity · Infection

    Source sentences

    Summary
    virus challenge experiment and HE staining confirmed that Tα1-BLP contributed to inhibition replication of the virus from chicken lungs
    2 context sentences
    Summary · context
    What's more, the viral loads and pathologic changes of lung tissue were observed by virus challenge experiment and HE staining to evaluate the immune protection of chickens.
    Summary · context
    To evaluate the immune adjuvant properties of Tα1-BLP, chickens were immunized with Tα1-BLP combined with H9N2 avian influenza whole-inactivated virus (WIV).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  8. 08AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    In chickens immunized with H9N2 inactivated virus plus the Tα1-BLP fusion peptide, the lungs were protected from damage after virus challenge.

    In plain wordsIn chickens, a vaccine given with a thymosin alpha‑1 fusion peptide protected the lungs from damage after virus exposure.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseLung damage after challenge
    Study

    chickenn: not reported in source

    H9N2 avian influenza WIV vaccination model
    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    protected the lungs from damage.
    2 context sentences
    Summary · context
    What's more, the viral loads and pathologic changes of lung tissue were observed by virus challenge experiment and HE staining to evaluate the immune protection of chickens.
    Summary · context
    To evaluate the immune adjuvant properties of Tα1-BLP, chickens were immunized with Tα1-BLP combined with H9N2 avian influenza whole-inactivated virus (WIV).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  9. 09LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Other

    The Tα1-BLP gene in a recombinant plasmid was successfully expressed in E. coli BL21.

    In plain wordsIn lab bacteria, the gene for the thymosin alpha‑1 fusion peptide was expressed successfully.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableRecombinant expression of Tα1-BLP gene
    Study

    Escherichia colin: not reported in source

    E. coli BL21
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    provided evidence that the gene of Tα1-BLP in a recombinant prokaryotic expression plasmid was successfully expressed in E. coli BL21

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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