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Study · PubMed tag: Network Meta-Analysis, Comparative Study · 2018

Retracted

Comparison of acupuncture and other drugs for chronic constipation: A network meta-analysis.

Zhu L, Ma Y, Deng X

PloS one25 Apr 2018Cited by 6 (Europe PMC)

PMID29694378 (opens in a new tab)PMCIDPMC5918910 (opens in a new tab)DOI10.1371/journal.pone.0196128 (opens in a new tab)PepBankPUB-29694378
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Summary

The objective of this study was to compare the efficacy and side effects of acupuncture, sham acupuncture and drugs in the treatment of chronic constipation. Randomized controlled trials (RCTs) assessing the effects of acupuncture and drugs for chronic constipation were comprehensively retrieved from electronic databases (such as PubMed, Cochrane Library, Embase, CNKI, Wanfang Database, VIP Database and CBM) up to December 2017. Additional references were obtained from review articles. With quality evaluations and data extraction, a network meta-analysis (NMA) was performed using a random-effects model under a frequentist framework. A total of 40 studies (n = 11032) were included: 39 were high-quality studies and 1 was a low-quality study. NMA showed that (1) acupuncture improved the symptoms of chronic constipation more effectively than drugs; (2) the ranking of treatments in terms of efficacy in diarrhoea-predominant irritable bowel syndrome was acupuncture, polyethylene glycol, lactulose, linaclotide, lubiprostone, bisacodyl, prucalopride, sham acupuncture, tegaserod, and placebo; (3) the ranking of side effects were as follows: lactulose, lubiprostone, bisacodyl, polyethylene glycol, prucalopride, linaclotide, placebo and tegaserod; and (4) the most commonly used acupuncture point for chronic constipation was ST25. Acupuncture is more effective than drugs in improving chronic constipation and has the least side effects. In the future, large-scale randomized controlled trials are needed to prove this. Sham acupuncture may have curative effects that are greater than the placebo effect. In the future, it is necessary to perform high-quality studies to support this finding. Polyethylene glycol also has acceptable curative effects with fewer side effects than other drugs.
CC BYText from Europe PMC. No result points at this text yet.

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This study is retracted. Results from a retracted study never count as evidence.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 16:37 UTC

    Status changed: status, notices · status retracted · status notice from Retraction Watch (Crossref)

  2. Version 1

    27 Oct 2026, 16:34 UTC

    First added · status retracted · source update from Europe PMC

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