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Study · Not a test of the peptide alone · 2018

1 result

Metformin ameliorates TGF-β1-induced osteoblastic differentiation of human aortic valve interstitial cells by inhibiting β-catenin signaling.

Liu F, Chu C, Wei Q, Shi J, Li H, Dong N

Biochemical and biophysical research communications22 Apr 2018Cited by 16 (Europe PMC)

PMID29679571 (opens in a new tab)DOI10.1016/j.bbrc.2018.04.141 (opens in a new tab)PepBankPUB-29679571
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In human valve cells, experiments using AICAR, Compound C and AMPKα siRNA implicated AMPKα in metformin protection against osteoblastic differentiation.

    In plain wordsIn cells, experiments using AICAR and other AMPK tools implicated AMPKα in metformin protection against bone-like differentiation.

    Peptide
    AICAR (acadesine)
    Outcome
    Not applicableAMPK mediation of metformin effects
    Study

    humann: not reported in source

    Human aortic valve interstitial cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Experiments using AICAR, Compound C and AMPKα siRNA showed that the beneficial effect of metformin on TGF-β1-induced osteoblastic differentiation of human AVICs was mediated by AMPKα.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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