Lixisenatide, a novel GLP-1 analog, protects against cerebral ischemia/reperfusion injury in diabetic rats.

Abdel-Latif RG, Heeba GH, Taye A, Khalifa MMA

Naunyn-Schmiedeberg's archives of pharmacology18 Apr 2018Cited by 31 (Europe PMC)

PMID29671019DOI10.1007/s00210-018-1497-1PepBankPUB-29671019

Publisher page PubMedAsk about this study

Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In diabetic rats with cerebral ischemia/reperfusion injury, lixisenatide ameliorated glucose intolerance.
In plain wordsIn rats with diabetes and brain injury, lixisenatide improved glucose intolerance.
Peptide
Lixisenatide
Outcome
DecreaseGlucose intolerance
Study
ratn: not reported in source
Adult male Wistar rats with diabetes and cerebral ischemia/reperfusion injury
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Apart from ameliorating glucose intolerance and insulin resistance,
2 context sentences(design, population, supporting numbers)
Summary · context
This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury.
Summary · context
T2DM-induced adult male Wistar rats were administered lixisenatide or glimepiride prior to induction of global cerebral I/R-induced injury.
Report a problemFND-2967101901
02AnimalAnimal study (in vivo)Mechanism
In diabetic rats with cerebral ischemia/reperfusion injury, lixisenatide ameliorated insulin resistance.
In plain wordsIn rats with diabetes and brain injury, lixisenatide improved insulin resistance.
Peptide
Lixisenatide
Outcome
DecreaseInsulin resistance
Study
ratn: not reported in source
Adult male Wistar rats with diabetes and cerebral ischemia/reperfusion injury
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Apart from ameliorating glucose intolerance and insulin resistance,
2 context sentences(design, population, supporting numbers)
Summary · context
This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury.
Summary · context
T2DM-induced adult male Wistar rats were administered lixisenatide or glimepiride prior to induction of global cerebral I/R-induced injury.
Report a problemFND-2967101902
03AnimalAnimal study (in vivo)Mechanism
In diabetic rats with cerebral injury, lixisenatide surpassed glimepiride in neurological function enhancement and suppression of oxidative stress, inflammation and apoptosis.
In plain wordsIn rats with diabetes and brain injury, lixisenatide surpassed glimepiride in neurological function and suppression of injury processes.
Peptide
Lixisenatide
Outcome
MixedNeurological function and cerebral injury pathways
Study
ratn: not reported in source
Adult male Wistar rats with diabetes and cerebral ischemia/reperfusion injury
Comparator
Glimepiride
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
lixisenatide was found to be superior to glimepiride as protective treatment in terms of enhancing behavioral/neurological functions and suppressing cerebral oxidative stress, inflammation, and apoptosis in cerebral I/R-injured diabetic rats.
2 context sentences(design, population, supporting numbers)
Summary · context
This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury.
Summary · context
T2DM-induced adult male Wistar rats were administered lixisenatide or glimepiride prior to induction of global cerebral I/R-induced injury.
Report a problemFND-2967101903
04AnimalAnimal study (in vivo)Mechanism
In diabetic rats with cerebral injury, lixisenatide relieved carotid endothelial dysfunction, unlike glimepiride.
In plain wordsIn rats with diabetes and brain injury, lixisenatide relieved carotid vessel dysfunction, unlike glimepiride.
Peptide
Lixisenatide
Outcome
DecreaseCarotid endothelial dysfunction
Study
ratn: not reported in source
Adult male Wistar rats with diabetes and cerebral ischemia/reperfusion injury
Comparator
Glimepiride
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Unlike glimepiride, lixisenatide relieved carotid endothelial dysfunction by increasing eNOS expression.
2 context sentences(design, population, supporting numbers)
Summary · context
This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury.
Summary · context
T2DM-induced adult male Wistar rats were administered lixisenatide or glimepiride prior to induction of global cerebral I/R-induced injury.
Report a problemFND-2967101904
05AnimalAnimal study (in vivo)Mechanism
In diabetic rats with cerebral injury, lixisenatide increased carotid eNOS expression, unlike glimepiride.
In plain wordsIn rats with diabetes and brain injury, lixisenatide increased carotid eNOS expression, unlike glimepiride.
Peptide
Lixisenatide
Outcome
IncreaseeNOS expression
Study
ratn: not reported in source
Adult male Wistar rats with diabetes and cerebral ischemia/reperfusion injury
Comparator
Glimepiride
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Unlike glimepiride, lixisenatide relieved carotid endothelial dysfunction by increasing eNOS expression.
2 context sentences(design, population, supporting numbers)
Summary · context
This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury.
Summary · context
T2DM-induced adult male Wistar rats were administered lixisenatide or glimepiride prior to induction of global cerebral I/R-induced injury.
Report a problemFND-2967101905
06AnimalAnimal study (in vivo)Mechanism
In diabetic rats with cerebral injury, lixisenatide dampened vascular nitrosative and oxidative stress.
In plain wordsIn rats with diabetes and brain injury, lixisenatide reduced vascular nitrosative and oxidative stress.
Peptide
Lixisenatide
Outcome
DecreaseVascular nitrosative and oxidative stress
Study
ratn: not reported in source
Adult male Wistar rats with diabetes and cerebral ischemia/reperfusion injury
Outcome group
Oxidative stress · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
It also dampened vascular nitrosative/oxidative stress via suppression of iNOS and NADPH oxidase expressions.
2 context sentences(design, population, supporting numbers)
Summary · context
This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury.
Summary · context
T2DM-induced adult male Wistar rats were administered lixisenatide or glimepiride prior to induction of global cerebral I/R-induced injury.
Report a problemFND-2967101906
07AnimalAnimal study (in vivo)Mechanism
In diabetic rats with cerebral injury, lixisenatide suppressed vascular iNOS expression.
In plain wordsIn rats with diabetes and brain injury, lixisenatide reduced vascular iNOS expression.
Peptide
Lixisenatide
Outcome
DecreaseiNOS expression
Study
ratn: not reported in source
Adult male Wistar rats with diabetes and cerebral ischemia/reperfusion injury
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
It also dampened vascular nitrosative/oxidative stress via suppression of iNOS and NADPH oxidase expressions.
2 context sentences(design, population, supporting numbers)
Summary · context
This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury.
Summary · context
T2DM-induced adult male Wistar rats were administered lixisenatide or glimepiride prior to induction of global cerebral I/R-induced injury.
Report a problemFND-2967101907
08AnimalAnimal study (in vivo)Mechanism
In diabetic rats with cerebral injury, lixisenatide suppressed vascular NADPH oxidase expression.
In plain wordsIn rats with diabetes and brain injury, lixisenatide reduced vascular NADPH oxidase expression.
Peptide
Lixisenatide
Outcome
DecreaseNADPH oxidase expression
Study
ratn: not reported in source
Adult male Wistar rats with diabetes and cerebral ischemia/reperfusion injury
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
It also dampened vascular nitrosative/oxidative stress via suppression of iNOS and NADPH oxidase expressions.
2 context sentences(design, population, supporting numbers)
Summary · context
This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury.
Summary · context
T2DM-induced adult male Wistar rats were administered lixisenatide or glimepiride prior to induction of global cerebral I/R-induced injury.
Report a problemFND-2967101908

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

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Lixisenatide, a novel GLP-1 analog, protects against cerebral ischemia/reperfusion injury in diabetic rats.

Summary

Results from this study8

Version history

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MeSH terms

Keywords