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Study · Animal study (in vivo) · rat · 2018

12 results

Effectiveness of arginase inhibitors against experimentally induced stroke.

Barakat W, Fahmy A, Askar M, El-Kannishy S

Naunyn-Schmiedeberg's archives of pharmacology29 Mar 2018Cited by 17 (Europe PMC)

PMID29600431 (opens in a new tab)DOI10.1007/s00210-018-1489-1 (opens in a new tab)PepBankPUB-29600431
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental stroke, Cerebrolysin ameliorated stroke-related behavior alteration.

    In plain wordsIn rats with experimental stroke, Cerebrolysin improved altered behavior.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableBehavior alteration
    Study

    ratn: not reported in source

    Middle cerebral artery occlusion
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with L-citruline and L-ornithine and the standard neuroprotective drug cerebrolysin ameliorated all the deleterious effects of stroke.
    2 context sentences
    Summary · context
    MCAO resulted in alteration in rat behavior, brain infarct, and edema associated with disruption of the blood-brain barrier (BBB).
    Summary · context
    The current study was designed to investigate the effect of arginase inhibitors (L-citruline and L-ornithine) against ischemic stroke induced in rats by middle cerebral artery occlusion (MCAO).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental stroke, Cerebrolysin ameliorated brain infarct.

    In plain wordsIn rats with experimental stroke, Cerebrolysin reduced brain infarct.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBrain infarct
    Study

    ratn: not reported in source

    Middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with L-citruline and L-ornithine and the standard neuroprotective drug cerebrolysin ameliorated all the deleterious effects of stroke.
    2 context sentences
    Summary · context
    MCAO resulted in alteration in rat behavior, brain infarct, and edema associated with disruption of the blood-brain barrier (BBB).
    Summary · context
    The current study was designed to investigate the effect of arginase inhibitors (L-citruline and L-ornithine) against ischemic stroke induced in rats by middle cerebral artery occlusion (MCAO).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental stroke, Cerebrolysin ameliorated brain edema.

    In plain wordsIn rats with experimental stroke, Cerebrolysin reduced brain swelling.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBrain edema
    Study

    ratn: not reported in source

    Middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with L-citruline and L-ornithine and the standard neuroprotective drug cerebrolysin ameliorated all the deleterious effects of stroke.
    2 context sentences
    Summary · context
    MCAO resulted in alteration in rat behavior, brain infarct, and edema associated with disruption of the blood-brain barrier (BBB).
    Summary · context
    The current study was designed to investigate the effect of arginase inhibitors (L-citruline and L-ornithine) against ischemic stroke induced in rats by middle cerebral artery occlusion (MCAO).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental stroke, Cerebrolysin ameliorated blood-brain barrier disruption.

    In plain wordsIn rats with experimental stroke, Cerebrolysin reduced blood-brain barrier disruption.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBlood-brain barrier disruption
    Study

    ratn: not reported in source

    Middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with L-citruline and L-ornithine and the standard neuroprotective drug cerebrolysin ameliorated all the deleterious effects of stroke.
    2 context sentences
    Summary · context
    MCAO resulted in alteration in rat behavior, brain infarct, and edema associated with disruption of the blood-brain barrier (BBB).
    Summary · context
    The current study was designed to investigate the effect of arginase inhibitors (L-citruline and L-ornithine) against ischemic stroke induced in rats by middle cerebral artery occlusion (MCAO).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with experimental stroke, Cerebrolysin ameliorated arginase I overexpression.

    In plain wordsIn rats with experimental stroke, Cerebrolysin reduced excess arginase I expression.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseArginase I expression
    Study

    ratn: not reported in source

    Middle cerebral artery occlusion
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with L-citruline and L-ornithine and the standard neuroprotective drug cerebrolysin ameliorated all the deleterious effects of stroke.
    2 context sentences
    Summary · context
    This was mediated through overexpression of arginase I and II, inducible NOS (iNOS), malondialdehyde (MDA), advanced glycation end products (AGEs), TNF-α, and IL-1β and downregulation of endothelial nitric oxide synthase (eNOS).
    Summary · context
    The current study was designed to investigate the effect of arginase inhibitors (L-citruline and L-ornithine) against ischemic stroke induced in rats by middle cerebral artery occlusion (MCAO).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with experimental stroke, Cerebrolysin ameliorated arginase II overexpression.

    In plain wordsIn rats with experimental stroke, Cerebrolysin reduced excess arginase II expression.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseArginase II expression
    Study

    ratn: not reported in source

    Middle cerebral artery occlusion
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with L-citruline and L-ornithine and the standard neuroprotective drug cerebrolysin ameliorated all the deleterious effects of stroke.
    2 context sentences
    Summary · context
    This was mediated through overexpression of arginase I and II, inducible NOS (iNOS), malondialdehyde (MDA), advanced glycation end products (AGEs), TNF-α, and IL-1β and downregulation of endothelial nitric oxide synthase (eNOS).
    Summary · context
    The current study was designed to investigate the effect of arginase inhibitors (L-citruline and L-ornithine) against ischemic stroke induced in rats by middle cerebral artery occlusion (MCAO).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats with experimental stroke, Cerebrolysin ameliorated inducible NOS overexpression.

    In plain wordsIn rats with experimental stroke, Cerebrolysin reduced excess inducible NOS expression.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseInducible NOS expression
    Study

    ratn: not reported in source

    Middle cerebral artery occlusion
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with L-citruline and L-ornithine and the standard neuroprotective drug cerebrolysin ameliorated all the deleterious effects of stroke.
    2 context sentences
    Summary · context
    This was mediated through overexpression of arginase I and II, inducible NOS (iNOS), malondialdehyde (MDA), advanced glycation end products (AGEs), TNF-α, and IL-1β and downregulation of endothelial nitric oxide synthase (eNOS).
    Summary · context
    The current study was designed to investigate the effect of arginase inhibitors (L-citruline and L-ornithine) against ischemic stroke induced in rats by middle cerebral artery occlusion (MCAO).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats with experimental stroke, Cerebrolysin ameliorated elevated malondialdehyde.

    In plain wordsIn rats with experimental stroke, Cerebrolysin reduced elevated malondialdehyde.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseMalondialdehyde
    Study

    ratn: not reported in source

    Middle cerebral artery occlusion
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with L-citruline and L-ornithine and the standard neuroprotective drug cerebrolysin ameliorated all the deleterious effects of stroke.
    2 context sentences
    Summary · context
    This was mediated through overexpression of arginase I and II, inducible NOS (iNOS), malondialdehyde (MDA), advanced glycation end products (AGEs), TNF-α, and IL-1β and downregulation of endothelial nitric oxide synthase (eNOS).
    Summary · context
    The current study was designed to investigate the effect of arginase inhibitors (L-citruline and L-ornithine) against ischemic stroke induced in rats by middle cerebral artery occlusion (MCAO).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats with experimental stroke, Cerebrolysin ameliorated elevated advanced glycation end products.

    In plain wordsIn rats with experimental stroke, Cerebrolysin reduced elevated advanced glycation end products.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAdvanced glycation end products
    Study

    ratn: not reported in source

    Middle cerebral artery occlusion
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with L-citruline and L-ornithine and the standard neuroprotective drug cerebrolysin ameliorated all the deleterious effects of stroke.
    2 context sentences
    Summary · context
    This was mediated through overexpression of arginase I and II, inducible NOS (iNOS), malondialdehyde (MDA), advanced glycation end products (AGEs), TNF-α, and IL-1β and downregulation of endothelial nitric oxide synthase (eNOS).
    Summary · context
    The current study was designed to investigate the effect of arginase inhibitors (L-citruline and L-ornithine) against ischemic stroke induced in rats by middle cerebral artery occlusion (MCAO).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats with experimental stroke, Cerebrolysin ameliorated elevated TNF-α.

    In plain wordsIn rats with experimental stroke, Cerebrolysin reduced elevated TNF-α.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseTNF-alpha
    Study

    ratn: not reported in source

    Middle cerebral artery occlusion
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with L-citruline and L-ornithine and the standard neuroprotective drug cerebrolysin ameliorated all the deleterious effects of stroke.
    2 context sentences
    Summary · context
    This was mediated through overexpression of arginase I and II, inducible NOS (iNOS), malondialdehyde (MDA), advanced glycation end products (AGEs), TNF-α, and IL-1β and downregulation of endothelial nitric oxide synthase (eNOS).
    Summary · context
    The current study was designed to investigate the effect of arginase inhibitors (L-citruline and L-ornithine) against ischemic stroke induced in rats by middle cerebral artery occlusion (MCAO).
  11. 11AnimalAnimal study (in vivo)Mechanism

    In rats with experimental stroke, Cerebrolysin ameliorated elevated IL-1β.

    In plain wordsIn rats with experimental stroke, Cerebrolysin reduced elevated IL-1β.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseIL-1beta
    Study

    ratn: not reported in source

    Middle cerebral artery occlusion
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with L-citruline and L-ornithine and the standard neuroprotective drug cerebrolysin ameliorated all the deleterious effects of stroke.
    2 context sentences
    Summary · context
    This was mediated through overexpression of arginase I and II, inducible NOS (iNOS), malondialdehyde (MDA), advanced glycation end products (AGEs), TNF-α, and IL-1β and downregulation of endothelial nitric oxide synthase (eNOS).
    Summary · context
    The current study was designed to investigate the effect of arginase inhibitors (L-citruline and L-ornithine) against ischemic stroke induced in rats by middle cerebral artery occlusion (MCAO).
  12. 12AnimalAnimal study (in vivo)Mechanism

    In rats with experimental stroke, Cerebrolysin ameliorated endothelial NOS downregulation.

    In plain wordsIn rats with experimental stroke, Cerebrolysin restored reduced endothelial NOS expression.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseEndothelial NOS expression
    Study

    ratn: not reported in source

    Middle cerebral artery occlusion
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with L-citruline and L-ornithine and the standard neuroprotective drug cerebrolysin ameliorated all the deleterious effects of stroke.
    2 context sentences
    Summary · context
    This was mediated through overexpression of arginase I and II, inducible NOS (iNOS), malondialdehyde (MDA), advanced glycation end products (AGEs), TNF-α, and IL-1β and downregulation of endothelial nitric oxide synthase (eNOS).
    Summary · context
    The current study was designed to investigate the effect of arginase inhibitors (L-citruline and L-ornithine) against ischemic stroke induced in rats by middle cerebral artery occlusion (MCAO).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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