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Study · Randomized controlled trial · n = 27 · 2018

3 results

Effects of Intranasal Oxytocin Administration on Sexual Functions in Healthy Women: A Laboratory Paradigm.

Kruger THC, Deiter F, Zhang Y, Jung S, Schippert C, Kahl KG, Heinrichs M, Schedlowski M, Hartmann U

Journal of clinical psychopharmacology1 Jun 2018Cited by 10 (Europe PMC)

PMID29596150 (opens in a new tab)DOI10.1097/jcp.0000000000000863 (opens in a new tab)PepBankPUB-29596150
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy women, intranasal oxytocin had no effect on subjective sexual parameters compared with placebo.

    In plain wordsIn healthy women, oxytocin nasal spray did not change self-reported sexual measures compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSubjective sexual parameters
    Study

    n = 27

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin administration showed no effect on subjective sexual parameters (eg, postorgasmic tension; P = 0.051).
    1 context sentence
    Summary · context
    In a double-blind, placebo-controlled, crossover laboratory setting, the acute effects of intranasal administered OXT (24 international units) on sexual drive, arousal, orgasm, and refractory aspects of sexual behavior were analyzed in 27 healthy females (mean age ± SD, 27.52 ± 8.04) together with p…
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy women, intranasal oxytocin did not affect vaginal photoplethysmography amplitude or vaginal blood volume compared with placebo.

    In plain wordsIn healthy women, oxytocin nasal spray did not change body measures of sexual arousal compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changePhysiological sexual arousal (vaginal photoplethysmography amplitude and blood volume)
    Study

    n = 27

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Physiological parameters (vaginal photoplethysmography amplitude and vaginal blood volume) showed a response pattern towards sexual arousal but were not affected by OXT.
    1 context sentence
    Summary · context
    In a double-blind, placebo-controlled, crossover laboratory setting, the acute effects of intranasal administered OXT (24 international units) on sexual drive, arousal, orgasm, and refractory aspects of sexual behavior were analyzed in 27 healthy females (mean age ± SD, 27.52 ± 8.04) together with p…
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy women, intranasal oxytocin did not affect sexual drive and other sexual functions compared with placebo.

    In plain wordsIn healthy women, oxytocin nasal spray did not change sexual drive or other sexual functions compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSexual drive and other sexual functions
    Study

    n = 27

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Also, sexual drive and other functions were not affected by OXT.
    1 context sentence
    Summary · context
    In a double-blind, placebo-controlled, crossover laboratory setting, the acute effects of intranasal administered OXT (24 international units) on sexual drive, arousal, orgasm, and refractory aspects of sexual behavior were analyzed in 27 healthy females (mean age ± SD, 27.52 ± 8.04) together with p…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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