Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals.

Cataldo LR, Fernández-Verdejo R, Santos JL, Galgani JE

Journal of investigative medicine : the official publication of the American Federation for Clinical Research27 Mar 2018Cited by 45 (Europe PMC)

PMID29593067DOI10.1136/jim-2017-000681PepBankPUB-29593067

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In lean and obese humans, plasma MOTS‑c concentration was similar between the groups.
In plain wordsNatural MOTS‑c levels in blood were similar in lean and obese people.
Peptide
MOTS-c
Outcome
No significant changePlasma MOTS-c in lean versus obese
Study
n = 20
Comparator
Lean individuals
Outcome group
Endogenous peptide levels · Metabolic and weight
Measurements
Plasma MOTS-c
0.48 ng/mL
lean
Plasma MOTS-c
0.52 ng/mL
obese
Source sentences
Summary
Although plasma MOTS-c concentration was similar in lean and obese individuals (0.48±0.16 and 0.52±0.15 ng/mL; p=0.60)
1 context sentence(design, population, supporting numbers)
Summary · context
To gain insight into MOTS-c regulation, we measured plasma MOTS-c concentration and analyzed its relationship with insulin sensitivity surrogates, in lean and obese humans (n=10 per group).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2959306701
02HumanEndogenous levelObservational studyOther
Plasma MOTS‑c concentration correlated positively with the HOMA index of insulin resistance.
In plain wordsHigher natural MOTS‑c levels were linked to higher insulin resistance scores.
Peptide
MOTS-c
Outcome
IncreaseMOTS-c correlation with HOMA
Study
n = 20
Outcome group
Glycemic control · Metabolic and weight
Measurements
Correlation with HOMA
0.53 r
all participants
Source sentences
Summary
it was correlated with HOMA (r=0.53; p<0.05) and Matsuda index (r=-0.46; p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
To gain insight into MOTS-c regulation, we measured plasma MOTS-c concentration and analyzed its relationship with insulin sensitivity surrogates, in lean and obese humans (n=10 per group).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2959306702
03HumanEndogenous levelObservational studyOther
Plasma MOTS‑c concentration correlated with the Matsuda insulin sensitivity index (r=-0.46).
In plain wordsNatural MOTS‑c levels were linked to the Matsuda insulin sensitivity score, in the direction of lower sensitivity with higher levels.
Peptide
MOTS-c
Outcome
DecreaseMOTS-c correlation with Matsuda index
Study
n = 20
Outcome group
Glycemic control · Metabolic and weight
Measurements
Correlation with Matsuda index
−0.46 r
all participants
Source sentences
Summary
it was correlated with HOMA (r=0.53; p<0.05) and Matsuda index (r=-0.46; p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
To gain insight into MOTS-c regulation, we measured plasma MOTS-c concentration and analyzed its relationship with insulin sensitivity surrogates, in lean and obese humans (n=10 per group).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2959306703
04HumanEndogenous levelObservational studyOther
When analysed separately, the associations between plasma MOTS‑c and insulin sensitivity measures remained only in lean individuals.
In plain wordsThe link between natural MOTS‑c and insulin resistance was seen only in lean people, not in obese people.
Peptide
MOTS-c
Outcome
MixedMOTS-c associations by group
Study
n = 20
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Notably, when the groups were analyzed separately, the associations remained only in lean individuals.
1 context sentence(design, population, supporting numbers)
Summary · context
To gain insight into MOTS-c regulation, we measured plasma MOTS-c concentration and analyzed its relationship with insulin sensitivity surrogates, in lean and obese humans (n=10 per group).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2959306704

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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