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Study · Measured the body's own peptide · 2018

2 results

Focal, but not global, cerebral ischaemia causes loss of myenteric neurons and upregulation of vasoactive intestinal peptide in mouse ileum.

Cheng X, Svensson M, Yang Y, Deierborg T, Ekblad E, Voss U

International journal of experimental pathology1 Feb 2018Cited by 8 (Europe PMC)

PMID29577471 (opens in a new tab)DOI10.1111/iep.12263 (opens in a new tab)PepBankPUB-29577471
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In mice with focal cerebral ischaemia (pMCAO), the number of VIP-immunoreactive submucous neurons in the ileum was higher 7 days after surgery than in sham mice.

    In plain wordsIn mice, a stroke-like brain injury raised the number of the body's own VIP-containing nerve cells in the gut.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP-immunoreactive submucous neurons 7 days after pMCAO
    Study

    mousen: not reported in source

    Mouse ileum after cerebral ischaemia (pMCAO, GCIR, CCH)
    Comparator
    Sham-operated mice
    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    an increased number of VIP-IR submucous neurons were found in mouse ileum 7 days after pMCAO.
    1 context sentence
    Summary · context
    Focal cerebral ischaemia, modelled by permanent middle cerebral artery occlusion (pMCAO) and global cerebral ischaemia, modelled with either transient occlusion of both common carotid arteries followed by reperfusion (GCIR) or chronic cerebral hypoperfusion (CCH) was performed on C56BL/6 mice.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In mice with global cerebral ischaemia (GCIR or CCH), relative numbers of VIP-immunoreactive ileal neurons did not change.

    In plain wordsIn mice, reduced blood flow to the whole brain did not change the number of the body's own VIP-containing gut nerve cells.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeVIP-immunoreactive neuron numbers after global cerebral ischaemia
    Study

    mousen: not reported in source

    Mouse ileum after cerebral ischaemia (pMCAO, GCIR, CCH)
    Comparator
    Sham-operated mice
    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    None of the global ischaemia models showed any alterations in neuronal survival or relative numbers of VIP- and nNOS-IR neurons.
    1 context sentence
    Summary · context
    Focal cerebral ischaemia, modelled by permanent middle cerebral artery occlusion (pMCAO) and global cerebral ischaemia, modelled with either transient occlusion of both common carotid arteries followed by reperfusion (GCIR) or chronic cerebral hypoperfusion (CCH) was performed on C56BL/6 mice.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:40 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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