Modulation of GABA- and Glycine-Activated Ionic Currents with Semax in Isolated Cerebral Neurons.

Sharonova IN, Bukanova YV, Myasoedov NF, Skrebitskii VG

Bulletin of experimental biology and medicine26 Mar 2018Cited by 2 (Europe PMC)

PMID29577196DOI10.1007/s10517-018-4043-8PepBankPUB-29577196

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In neurons isolated from rat cerebellum, Semax at 1 μM augmented the amplitude of GABA-activated ionic currents in Purkinje cells by 147±13%.
In plain wordsIn isolated rat nerve cells, Semax strengthened GABA-activated electrical currents in cerebellar Purkinje cells.
Peptide
Semax
Outcome
IncreaseGABA-activated current amplitude in cerebellum Purkinje cells
Study
ratn: not reported in source
neurons isolated from rat brain (concentration-clamp)
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
1 μM · perfusion solutionAs given in this study (rat).
Measurements
GABA-activated current amplitude increase
147%
cerebellum Purkinje cells, 1 μM
Source sentences
Summary
The concentration-clamp experiments with neurons isolated from the rat brain showed that nootropic and neuroprotective drug Semax added to perfusion solution at concentration of 1 μM augmented the amplitude of GABA-activated ionic currents in cerebellum Purkinje cells by 147±13%.
Report a problemFND-2957719601
02LabIn vitro (cells)Activity measurement
In neurons isolated from rat hippocampus, Semax at 0.1 μM diminished the amplitude of glycine-activated chloride currents to 68% of the control level.
In plain wordsIn isolated rat nerve cells, Semax weakened glycine-activated currents in hippocampal neurons.
Peptide
Semax
Outcome
DecreaseGlycine-activated current amplitude in hippocampal pyramidal neurons (0.1 μM)
Study
ratn: not reported in source
neurons isolated from rat brain (concentration-clamp)
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.1 μM · perfusion solutionAs given in this study (rat).
Measurements
Glycine-activated current amplitude
68 % of control
hippocampal pyramidal neurons, 0.1 μM
Source sentences
Summary
In addition, Semax in perfusion solution (0.1 and 1 μM) diminished the amplitude of glycine-activated chloride currents in hippocampal pyramidal neurons down to 68 and 43% control level, respectively.
Report a problemFND-2957719602
03LabIn vitro (cells)Activity measurement
In neurons isolated from rat hippocampus, Semax at 1 μM diminished the amplitude of glycine-activated chloride currents to 43% of the control level.
In plain wordsIn isolated rat nerve cells, Semax at a higher concentration weakened glycine-activated currents in hippocampal neurons more strongly.
Peptide
Semax
Outcome
DecreaseGlycine-activated current amplitude in hippocampal pyramidal neurons (1 μM)
Study
ratn: not reported in source
neurons isolated from rat brain (concentration-clamp)
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
1 μM · perfusion solutionAs given in this study (rat).
Measurements
Glycine-activated current amplitude
43 % of control
hippocampal pyramidal neurons, 1 μM
Source sentences
Summary
In addition, Semax in perfusion solution (0.1 and 1 μM) diminished the amplitude of glycine-activated chloride currents in hippocampal pyramidal neurons down to 68 and 43% control level, respectively.
Report a problemFND-2957719603
04LabIn vitro (cells)Activity measurement
In isolated rat brain neurons, Semax accelerated the falling edge of glycine-activated current, both after short co-application with the agonist and after addition to the perfusion solution.
In plain wordsIn isolated rat nerve cells, Semax made glycine-activated currents fade faster.
Peptide
Semax
Outcome
DecreaseFalling edge of glycine-activated current
Study
ratn: not reported in source
neurons isolated from rat brain (concentration-clamp)
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · perfusion solutionAs given in this study (rat).
Source sentences
Summary
Semax accelerated the falling edge of glycine-activated current both after a short-term co-application with agonist and after addition of this peptide into perfusion solution.
Report a problemFND-2957719604
05LabIn vitro (cells)Activity measurement
In isolated rat brain neurons, the potentiating and inhibitory effects of Semax developed slowly and were poorly reversible.
In plain wordsIn isolated rat nerve cells, Semax effects on these currents built up slowly and hardly reversed.
Peptide
Semax
Outcome
Not applicableTime course and reversibility of Semax effects on GABA and glycine currents
Study
ratn: not reported in source
neurons isolated from rat brain (concentration-clamp)
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · perfusion solutionAs given in this study (rat).
Source sentences
Summary
Both potentiating and inhibitory effects developed slowly, and they were poorly reversible, which indicated a probable implication of second messengers in the observed phenomena.
Report a problemFND-2957719605

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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