Inherently Lean Rats Have Enhanced Activity and Skeletal Muscle Response to Central Melanocortin Receptors.

Gavini CK, Britton SL, Koch LG, Novak CM

Obesity (Silver Spring, Md.)22 Mar 2018Cited by 9 (Europe PMC)

PMID29566460PMCIDPMC5916025DOI10.1002/oby.22166PepBankPUB-29566460

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In inherently lean HCR rats, intra-VMH MTII changed energy expenditure significantly more than in LCR rats.
In plain wordsIn naturally lean rats, MTII injected into the brain changed energy use more than in less lean rats.
Peptide
Melanotan II
Outcome
IncreaseMTII-induced change in energy expenditure
Study
ratn: not reported in source
High-capacity (HCR) and low-capacity (LCR) runner rats
Comparator
LCR rats
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · intra-VMH microinjectionAs given in this study (rat).
Source sentences
Summary
HCR were significantly more responsive to intra-VMH MTII-induced changes in EE, activity EE, norepinephrine turnover to some muscle subgroups, and muscle mRNA expression of some energetic modulators.
1 context sentence(design, population, supporting numbers)
Summary · context
HCR and LCR rats received intra-VMH microinjections of melanotan II (MTII), a mixed melanocortin receptor agonist.
Report a problemFND-2956646001
02AnimalAnimal study (in vivo)Efficacy outcome
HCR rats showed a significantly greater MTII-induced change in activity energy expenditure than LCR rats.
In plain wordsIn naturally lean rats, MTII changed activity-related energy use more than in less lean rats.
Peptide
Melanotan II
Outcome
IncreaseMTII-induced change in activity energy expenditure
Study
ratn: not reported in source
High-capacity (HCR) and low-capacity (LCR) runner rats
Comparator
LCR rats
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · intra-VMH microinjectionAs given in this study (rat).
Source sentences
Summary
HCR were significantly more responsive to intra-VMH MTII-induced changes in EE, activity EE, norepinephrine turnover to some muscle subgroups, and muscle mRNA expression of some energetic modulators.
2 context sentences(design, population, supporting numbers)
Summary · context
An inherently lean, high-capacity rat phenotype showed elevated response to central melanocortin stimulation of activity EE and use of fat as fuel.
Summary · context
HCR and LCR rats received intra-VMH microinjections of melanotan II (MTII), a mixed melanocortin receptor agonist.
Report a problemFND-2956646002
03AnimalAnimal study (in vivo)Efficacy outcome
HCR rats showed greater MTII-induced norepinephrine turnover in some muscle subgroups than LCR rats.
In plain wordsIn naturally lean rats, MTII raised nerve signalling to some muscles more than in less lean rats.
Peptide
Melanotan II
Outcome
IncreaseMTII-induced norepinephrine turnover in muscle
Study
ratn: not reported in source
High-capacity (HCR) and low-capacity (LCR) runner rats
Comparator
LCR rats
Outcome group
Energy expenditure and thermogenesis · Musculoskeletal
Studied dose
Dose not stated · intra-VMH microinjectionAs given in this study (rat).
Source sentences
Summary
HCR were significantly more responsive to intra-VMH MTII-induced changes in EE, activity EE, norepinephrine turnover to some muscle subgroups, and muscle mRNA expression of some energetic modulators.
2 context sentences(design, population, supporting numbers)
Summary · context
This may be driven by sympathetic outflow to skeletal muscle, which was elevated after MTII.
Summary · context
HCR and LCR rats received intra-VMH microinjections of melanotan II (MTII), a mixed melanocortin receptor agonist.
Report a problemFND-2956646003
04AnimalAnimal study (in vivo)Efficacy outcome
HCR rats showed greater MTII-induced changes in muscle mRNA expression of some energetic modulators than LCR rats.
In plain wordsIn naturally lean rats, MTII changed the activity of some muscle energy genes more than in less lean rats.
Peptide
Melanotan II
Outcome
MixedMTII-induced muscle mRNA expression of energetic modulators
Study
ratn: not reported in source
High-capacity (HCR) and low-capacity (LCR) runner rats
Comparator
LCR rats
Outcome group
Energy expenditure and thermogenesis · Musculoskeletal
Studied dose
Dose not stated · intra-VMH microinjectionAs given in this study (rat).
Source sentences
Summary
HCR were significantly more responsive to intra-VMH MTII-induced changes in EE, activity EE, norepinephrine turnover to some muscle subgroups, and muscle mRNA expression of some energetic modulators.
2 context sentences(design, population, supporting numbers)
Summary · context
Central melanocortin receptor activation also altered skeletal muscle energetic modulators in a manner consistent with elevated EE and lowered respiratory exchange ratio.
Summary · context
HCR and LCR rats received intra-VMH microinjections of melanotan II (MTII), a mixed melanocortin receptor agonist.
Report a problemFND-2956646004
05AnimalAnimal study (in vivo)Efficacy outcome
Limited MTII-induced modulation of muscle thermogenesis during activity was seen in LCR rats only, not in HCR rats.
In plain wordsIn rats, MTII slightly changed muscle heat during activity only in the less lean group, not in the naturally lean group.
Peptide
Melanotan II
Outcome
MixedMTII modulation of muscle thermogenesis during activity
Study
ratn: not reported in source
High-capacity (HCR) and low-capacity (LCR) runner rats
Comparator
LCR rats
Outcome group
Energy expenditure and thermogenesis · Musculoskeletal
Studied dose
Dose not stated · intra-VMH microinjectionAs given in this study (rat).
Source sentences
Summary
Though HCR had high muscle activity thermogenesis, limited MTII-induced modulation of muscle thermogenesis during activity was seen in LCR only.
1 context sentence(design, population, supporting numbers)
Summary · context
HCR and LCR rats received intra-VMH microinjections of melanotan II (MTII), a mixed melanocortin receptor agonist.
Report a problemFND-2956646005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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