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Study · Animal study (in vivo) · mouse · 2018

12 results

Durability of protective effect of dulaglutide on pancreatic β-cells in diabetic mice: GLP-1 receptor expression is not reduced despite long-term dulaglutide exposure.

Kimura T, Obata A, Shimoda M, Hirukawa H, Kanda-Kimura Y, Nogami Y, Kohara K, Nakanishi S, Mune T, Kaku K, Kaneto H

Diabetes & metabolism6 Feb 2018Cited by 35 (Europe PMC)

PMID29525225 (opens in a new tab)DOI10.1016/j.diabet.2017.10.007 (opens in a new tab)PepBankPUB-29525225
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In db/m mice, dulaglutide did not decrease beta-cell GLP-1R expression compared with controls.

    In plain wordsIn mice without diabetes, dulaglutide did not decrease beta-cell GLP-1R expression compared with controls.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    No significant changeBeta-cell GLP-1R expression in non-diabetic mice
    Study

    mousen: not reported in source

    db/m mice
    Comparator
    Control vehicle
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    0.6 mg/kg twice weekly · 17 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In db/m mice, GLP-1R expression in β-cells did not decrease, not even after long-term administration of Dula, compared with control mice
    1 context sentence
    Summary · context
    Seven-week-old male db/db and db/m mice were given either Dula (0.6mg/kg×2/week) or a control vehicle (CTL) for 17 weeks.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In db/db mice, dulaglutide increased GLP-1R expression compared with control db/db mice.

    In plain wordsIn diabetic mice, dulaglutide increased GLP-1R expression compared with control diabetic mice.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseBeta-cell GLP-1R expression in diabetic mice
    Study

    mousen: not reported in source

    db/db mice
    Comparator
    Control vehicle
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    0.6 mg/kg twice weekly · 17 weeksAs given in this study (mouse).

    Source sentences

    Summary
    while GLP-1R expression in 24-week-old db/db mice treated with Dula was augmented, rather than downregulated, compared with 24-week-old CTL db/db mice.
    1 context sentence
    Summary · context
    Seven-week-old male db/db and db/m mice were given either Dula (0.6mg/kg×2/week) or a control vehicle (CTL) for 17 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In db/db mice, dulaglutide decreased food intake compared with controls.

    In plain wordsIn diabetic mice, dulaglutide decreased food intake compared with controls.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseFood intake
    Study

    mousen: not reported in source

    db/db mice
    Comparator
    Control vehicle
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.6 mg/kg twice weekly · 17 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In db/db mice treated with Dula, food intake and blood glucose levels were significantly decreased up to 24 weeks of age compared with CTL db/db mice, and their expression levels of various β-cell-related genes, insulin content and GSIS were also enhanced.
    1 context sentence
    Summary · context
    Seven-week-old male db/db and db/m mice were given either Dula (0.6mg/kg×2/week) or a control vehicle (CTL) for 17 weeks.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In db/db mice, dulaglutide decreased blood glucose compared with controls.

    In plain wordsIn diabetic mice, dulaglutide decreased blood glucose compared with controls.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseBlood glucose
    Study

    mousen: not reported in source

    db/db mice
    Comparator
    Control vehicle
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0.6 mg/kg twice weekly · 17 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In db/db mice treated with Dula, food intake and blood glucose levels were significantly decreased up to 24 weeks of age compared with CTL db/db mice, and their expression levels of various β-cell-related genes, insulin content and GSIS were also enhanced.
    1 context sentence
    Summary · context
    Seven-week-old male db/db and db/m mice were given either Dula (0.6mg/kg×2/week) or a control vehicle (CTL) for 17 weeks.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In db/db mice, dulaglutide enhanced beta-cell-related gene expression compared with controls.

    In plain wordsIn diabetic mice, dulaglutide increased beta-cell-related gene expression compared with controls.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseBeta-cell-related gene expression
    Study

    mousen: not reported in source

    db/db mice
    Comparator
    Control vehicle
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    0.6 mg/kg twice weekly · 17 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In db/db mice treated with Dula, food intake and blood glucose levels were significantly decreased up to 24 weeks of age compared with CTL db/db mice, and their expression levels of various β-cell-related genes, insulin content and GSIS were also enhanced.
    1 context sentence
    Summary · context
    Seven-week-old male db/db and db/m mice were given either Dula (0.6mg/kg×2/week) or a control vehicle (CTL) for 17 weeks.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In db/db mice, dulaglutide enhanced insulin content compared with controls.

    In plain wordsIn diabetic mice, dulaglutide increased insulin content compared with controls.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseIslet insulin content
    Study

    mousen: not reported in source

    db/db mice
    Comparator
    Control vehicle
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    0.6 mg/kg twice weekly · 17 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In db/db mice treated with Dula, food intake and blood glucose levels were significantly decreased up to 24 weeks of age compared with CTL db/db mice, and their expression levels of various β-cell-related genes, insulin content and GSIS were also enhanced.
    1 context sentence
    Summary · context
    Seven-week-old male db/db and db/m mice were given either Dula (0.6mg/kg×2/week) or a control vehicle (CTL) for 17 weeks.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In db/db mice, dulaglutide enhanced glucose-stimulated insulin secretion compared with controls.

    In plain wordsIn diabetic mice, dulaglutide increased glucose-stimulated insulin secretion compared with controls.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseGlucose-stimulated insulin secretion
    Study

    mousen: not reported in source

    db/db mice
    Comparator
    Control vehicle
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    0.6 mg/kg twice weekly · 17 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In db/db mice treated with Dula, food intake and blood glucose levels were significantly decreased up to 24 weeks of age compared with CTL db/db mice, and their expression levels of various β-cell-related genes, insulin content and GSIS were also enhanced.
    1 context sentence
    Summary · context
    Seven-week-old male db/db and db/m mice were given either Dula (0.6mg/kg×2/week) or a control vehicle (CTL) for 17 weeks.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In db/db mice, dulaglutide suppressed oxidative stress compared with controls.

    In plain wordsIn diabetic mice, dulaglutide reduced oxidative stress compared with controls.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseOxidative stress
    Study

    mousen: not reported in source

    db/db mice
    Comparator
    Control vehicle
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    0.6 mg/kg twice weekly · 17 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In contrast, oxidative and endoplasmic reticulum stress, inflammation, fibrosis and apoptosis were suppressed with Dula treatment.
    1 context sentence
    Summary · context
    Seven-week-old male db/db and db/m mice were given either Dula (0.6mg/kg×2/week) or a control vehicle (CTL) for 17 weeks.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In db/db mice, dulaglutide suppressed endoplasmic reticulum stress compared with controls.

    In plain wordsIn diabetic mice, dulaglutide reduced endoplasmic reticulum stress compared with controls.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseEndoplasmic reticulum stress
    Study

    mousen: not reported in source

    db/db mice
    Comparator
    Control vehicle
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    0.6 mg/kg twice weekly · 17 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In contrast, oxidative and endoplasmic reticulum stress, inflammation, fibrosis and apoptosis were suppressed with Dula treatment.
    1 context sentence
    Summary · context
    Seven-week-old male db/db and db/m mice were given either Dula (0.6mg/kg×2/week) or a control vehicle (CTL) for 17 weeks.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In db/db mice, dulaglutide suppressed inflammation compared with controls.

    In plain wordsIn diabetic mice, dulaglutide reduced inflammation compared with controls.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseInflammation
    Study

    mousen: not reported in source

    db/db mice
    Comparator
    Control vehicle
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    0.6 mg/kg twice weekly · 17 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In contrast, oxidative and endoplasmic reticulum stress, inflammation, fibrosis and apoptosis were suppressed with Dula treatment.
    1 context sentence
    Summary · context
    Seven-week-old male db/db and db/m mice were given either Dula (0.6mg/kg×2/week) or a control vehicle (CTL) for 17 weeks.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In db/db mice, dulaglutide suppressed fibrosis compared with controls.

    In plain wordsIn diabetic mice, dulaglutide reduced fibrosis compared with controls.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseFibrosis
    Study

    mousen: not reported in source

    db/db mice
    Comparator
    Control vehicle
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    0.6 mg/kg twice weekly · 17 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In contrast, oxidative and endoplasmic reticulum stress, inflammation, fibrosis and apoptosis were suppressed with Dula treatment.
    1 context sentence
    Summary · context
    Seven-week-old male db/db and db/m mice were given either Dula (0.6mg/kg×2/week) or a control vehicle (CTL) for 17 weeks.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In db/db mice, dulaglutide suppressed apoptosis compared with controls.

    In plain wordsIn diabetic mice, dulaglutide reduced cell death compared with controls.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseApoptosis
    Study

    mousen: not reported in source

    db/db mice
    Comparator
    Control vehicle
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    0.6 mg/kg twice weekly · 17 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In contrast, oxidative and endoplasmic reticulum stress, inflammation, fibrosis and apoptosis were suppressed with Dula treatment.
    1 context sentence
    Summary · context
    Seven-week-old male db/db and db/m mice were given either Dula (0.6mg/kg×2/week) or a control vehicle (CTL) for 17 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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