PTH (1-34) and growth hormone in prevention of disuse osteopenia and sarcopenia in rats.

Brent MB, Brüel A, Thomsen JS

Bone20 Feb 2018Cited by 28 (Europe PMC)

PMID29475111DOI10.1016/j.bone.2018.02.017PepBankPUB-29475111

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with disuse, PTH fully counteracted immobilization-related loss of trabecular BV/TV versus BTX alone.
In plain wordsIn rats, PTH prevented the loss of trabecular bone volume compared with disuse alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTrabecular BV/TV
Study
ratsn: not reported in source
Female Wistar rats with botulinum toxin-induced disuse
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 μg/kg/day · 6 weeksAs given in this study (rats).
Source sentences
Summary
PTH fully counteracted the immobilization-induced lower BV/TV, Tb.Th, and distal femoral metaphyseal strength.
3 context sentences(design, population, supporting numbers)
Summary · context
Disuse was achieved by injecting 4IU botulinum toxin A (BTX) into the right hindlimb musculature of 12-14-week-old female Wistar rats.
Summary · context
PTH (1-34) (60μg/kg/day) and GH (5mg/kg/day).
Summary · context
The animals were sacrificed after 6weeks of treatment.
Report a problemFND-2947511101
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with disuse, PTH fully counteracted immobilization-related loss of trabecular thickness versus BTX alone.
In plain wordsIn rats, PTH prevented the loss of trabecular thickness compared with disuse alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTrabecular thickness
Study
ratsn: not reported in source
Female Wistar rats with botulinum toxin-induced disuse
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 μg/kg/day · 6 weeksAs given in this study (rats).
Source sentences
Summary
PTH fully counteracted the immobilization-induced lower BV/TV, Tb.Th, and distal femoral metaphyseal strength.
3 context sentences(design, population, supporting numbers)
Summary · context
Disuse was achieved by injecting 4IU botulinum toxin A (BTX) into the right hindlimb musculature of 12-14-week-old female Wistar rats.
Summary · context
PTH (1-34) (60μg/kg/day) and GH (5mg/kg/day).
Summary · context
The animals were sacrificed after 6weeks of treatment.
Report a problemFND-2947511102
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with disuse, PTH fully counteracted immobilization-related loss of distal femoral metaphyseal strength versus BTX alone.
In plain wordsIn rats, PTH prevented the loss of femoral bone strength compared with disuse alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseDistal femoral metaphyseal strength
Study
ratsn: not reported in source
Female Wistar rats with botulinum toxin-induced disuse
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
60 μg/kg/day · 6 weeksAs given in this study (rats).
Source sentences
Summary
PTH fully counteracted the immobilization-induced lower BV/TV, Tb.Th, and distal femoral metaphyseal strength.
3 context sentences(design, population, supporting numbers)
Summary · context
Disuse was achieved by injecting 4IU botulinum toxin A (BTX) into the right hindlimb musculature of 12-14-week-old female Wistar rats.
Summary · context
PTH (1-34) (60μg/kg/day) and GH (5mg/kg/day).
Summary · context
The animals were sacrificed after 6weeks of treatment.
Report a problemFND-2947511103

Studies that did not test the peptide alone5

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

04AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In rats with disuse, combined PTH and GH increased distal femoral metaphyseal strength versus BTX alone.
In plain wordsIn rats, PTH with growth hormone increased femoral bone strength compared with disuse alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCombination distal femoral metaphyseal strength
Study
ratsn: not reported in source
Female Wistar rats with botulinum toxin-induced disuse
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Measurements
Bone strength increase
45%
PTH plus GH versus BTX
Source sentences
Summary
Combination of PTH and GH increased distal femoral metaphyseal bone strength (+45%, p<0.001), BV/TV (+50%, p<0.05), Tb.Th (+40%, p<0.05), and whole femoral aBMD (+15%, p<0.001) compared to BTX and muscle mass (+21%, p<0.05) compared to BTX+PTH.
3 context sentences(design, population, supporting numbers)
Summary · context
Disuse was achieved by injecting 4IU botulinum toxin A (BTX) into the right hindlimb musculature of 12-14-week-old female Wistar rats.
Summary · context
PTH (1-34) (60μg/kg/day) and GH (5mg/kg/day).
Summary · context
The animals were sacrificed after 6weeks of treatment.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2947511104
05AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In rats with disuse, combined PTH and GH increased trabecular BV/TV versus BTX alone.
In plain wordsIn rats, PTH with growth hormone increased trabecular bone volume compared with disuse alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCombination trabecular BV/TV
Study
ratsn: not reported in source
Female Wistar rats with botulinum toxin-induced disuse
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Measurements
BV/TV increase
50%
PTH plus GH versus BTX
Source sentences
Summary
Combination of PTH and GH increased distal femoral metaphyseal bone strength (+45%, p<0.001), BV/TV (+50%, p<0.05), Tb.Th (+40%, p<0.05), and whole femoral aBMD (+15%, p<0.001) compared to BTX and muscle mass (+21%, p<0.05) compared to BTX+PTH.
3 context sentences(design, population, supporting numbers)
Summary · context
Disuse was achieved by injecting 4IU botulinum toxin A (BTX) into the right hindlimb musculature of 12-14-week-old female Wistar rats.
Summary · context
PTH (1-34) (60μg/kg/day) and GH (5mg/kg/day).
Summary · context
The animals were sacrificed after 6weeks of treatment.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2947511105
06AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In rats with disuse, combined PTH and GH increased trabecular thickness versus BTX alone.
In plain wordsIn rats, PTH with growth hormone increased trabecular thickness compared with disuse alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCombination trabecular thickness
Study
ratsn: not reported in source
Female Wistar rats with botulinum toxin-induced disuse
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Measurements
Trabecular thickness increase
40%
PTH plus GH versus BTX
Source sentences
Summary
Combination of PTH and GH increased distal femoral metaphyseal bone strength (+45%, p<0.001), BV/TV (+50%, p<0.05), Tb.Th (+40%, p<0.05), and whole femoral aBMD (+15%, p<0.001) compared to BTX and muscle mass (+21%, p<0.05) compared to BTX+PTH.
3 context sentences(design, population, supporting numbers)
Summary · context
Disuse was achieved by injecting 4IU botulinum toxin A (BTX) into the right hindlimb musculature of 12-14-week-old female Wistar rats.
Summary · context
PTH (1-34) (60μg/kg/day) and GH (5mg/kg/day).
Summary · context
The animals were sacrificed after 6weeks of treatment.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2947511106
07AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In rats with disuse, combined PTH and GH increased whole femoral areal BMD versus BTX alone.
In plain wordsIn rats, PTH with growth hormone increased femoral bone density compared with disuse alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCombination whole femoral aBMD
Study
ratsn: not reported in source
Female Wistar rats with botulinum toxin-induced disuse
Comparator
BTX alone
Outcome group
Bone and joint · Musculoskeletal
Measurements
aBMD increase
15%
PTH plus GH versus BTX
Source sentences
Summary
Combination of PTH and GH increased distal femoral metaphyseal bone strength (+45%, p<0.001), BV/TV (+50%, p<0.05), Tb.Th (+40%, p<0.05), and whole femoral aBMD (+15%, p<0.001) compared to BTX and muscle mass (+21%, p<0.05) compared to BTX+PTH.
3 context sentences(design, population, supporting numbers)
Summary · context
Disuse was achieved by injecting 4IU botulinum toxin A (BTX) into the right hindlimb musculature of 12-14-week-old female Wistar rats.
Summary · context
PTH (1-34) (60μg/kg/day) and GH (5mg/kg/day).
Summary · context
The animals were sacrificed after 6weeks of treatment.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2947511107
08AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In rats with disuse, combined PTH and GH increased muscle mass versus PTH alone during BTX-induced disuse.
In plain wordsIn rats, PTH with growth hormone increased muscle mass compared with PTH alone during disuse.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCombination muscle mass
Study
ratsn: not reported in source
Female Wistar rats with botulinum toxin-induced disuse
Comparator
BTX plus PTH
Outcome group
Muscle injury and repair · Musculoskeletal
Measurements
Muscle mass increase
21%
PTH plus GH versus BTX plus PTH
Source sentences
Summary
Combination of PTH and GH increased distal femoral metaphyseal bone strength (+45%, p<0.001), BV/TV (+50%, p<0.05), Tb.Th (+40%, p<0.05), and whole femoral aBMD (+15%, p<0.001) compared to BTX and muscle mass (+21%, p<0.05) compared to BTX+PTH.
3 context sentences(design, population, supporting numbers)
Summary · context
Disuse was achieved by injecting 4IU botulinum toxin A (BTX) into the right hindlimb musculature of 12-14-week-old female Wistar rats.
Summary · context
PTH (1-34) (60μg/kg/day) and GH (5mg/kg/day).
Summary · context
The animals were sacrificed after 6weeks of treatment.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2947511108

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Keywords

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