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Study · In vitro (cells) · 2018

11 results

Mechano-growth factor protects against mechanical overload induced damage and promotes migration of growth plate chondrocytes through RhoA/YAP pathway.

Jing X, Ye Y, Bao Y, Zhang J, Huang J, Wang R, Guo J, Guo F

Experimental cell research20 Feb 2018Cited by 14 (Europe PMC)

PMID29470961 (opens in a new tab)DOI10.1016/j.yexcr.2018.02.021 (opens in a new tab)PepBankPUB-29470961
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In growth plate chondrocytes, MGF treatment had no effect on proliferation.

    In plain wordsIn growth plate cells in a dish, MGF did not change how fast the cells multiplied.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeChondrocyte proliferation
    Study

    n: not reported in source

    growth plate chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment of MGF had no effect on growth plate chondrocytes proliferation and differentiation.
    1 context sentence
    Summary · context
    In the present study, we found that MGF mRNA expression of growth plate chondrocytes was upregulated in response to mechanical stimuli.
  2. 02LabIn vitro (cells)Efficacy outcome

    In growth plate chondrocytes, MGF treatment had no effect on differentiation.

    In plain wordsIn growth plate cells in a dish, MGF did not change how the cells matured.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeChondrocyte differentiation
    Study

    n: not reported in source

    growth plate chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment of MGF had no effect on growth plate chondrocytes proliferation and differentiation.
    1 context sentence
    Summary · context
    In the present study, we found that MGF mRNA expression of growth plate chondrocytes was upregulated in response to mechanical stimuli.
  3. 03LabIn vitro (cells)Efficacy outcome

    In growth plate chondrocytes under mechanical overload, MGF inhibited apoptosis.

    In plain wordsIn growth plate cells in a dish under mechanical strain, MGF reduced cell death.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseChondrocyte apoptosis under mechanical overload
    Study

    n: not reported in source

    growth plate chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    But it could inhibit growth plate chondrocytes apoptosis and inflammation under mechanical overload.
    1 context sentence
    Summary · context
    In the present study, we found that MGF mRNA expression of growth plate chondrocytes was upregulated in response to mechanical stimuli.
  4. 04LabIn vitro (cells)Efficacy outcome

    In growth plate chondrocytes under mechanical overload, MGF inhibited inflammation.

    In plain wordsIn growth plate cells in a dish under mechanical strain, MGF reduced inflammation.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseChondrocyte inflammation under mechanical overload
    Study

    n: not reported in source

    growth plate chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    But it could inhibit growth plate chondrocytes apoptosis and inflammation under mechanical overload.
    1 context sentence
    Summary · context
    In the present study, we found that MGF mRNA expression of growth plate chondrocytes was upregulated in response to mechanical stimuli.
  5. 05LabIn vitro (cells)Efficacy outcome

    In growth plate chondrocytes, MGF significantly enhanced migration in wound healing and transwell assays.

    In plain wordsIn growth plate cells in a dish, MGF made the cells move more.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseChondrocyte migration
    Study

    n: not reported in source

    growth plate chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, both wound healing and transwell assay indicated that MGF could significantly enhance growth plate chondrocytes migration which was accompanied with YAP activation and nucleus translocation.
    1 context sentence
    Summary · context
    In the present study, we found that MGF mRNA expression of growth plate chondrocytes was upregulated in response to mechanical stimuli.
  6. 06LabIn vitro (cells)Mechanism

    In growth plate chondrocytes, MGF-enhanced migration was accompanied by YAP activation and nucleus translocation.

    In plain wordsIn growth plate cells in a dish, the faster cell movement with MGF came with activation of the YAP protein.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseYAP activation and nuclear translocation
    Study

    n: not reported in source

    growth plate chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, both wound healing and transwell assay indicated that MGF could significantly enhance growth plate chondrocytes migration which was accompanied with YAP activation and nucleus translocation.
    1 context sentence
    Summary · context
    In the present study, we found that MGF mRNA expression of growth plate chondrocytes was upregulated in response to mechanical stimuli.
  7. 07LabIn vitro (cells)Mechanism

    In growth plate chondrocytes, knockdown of YAP with siRNA suppressed the migration induced by MGF.

    In plain wordsIn growth plate cells in a dish, MGF needed the YAP protein to make cells move.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableYAP dependence of MGF-induced migration
    Study

    n: not reported in source

    growth plate chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Knockdown of YAP with YAP siRNA suppressed migration induced by MGF, indicating the essential role of YAP in MGF promoting growth plate chondrocytes migration.
    1 context sentence
    Summary · context
    In the present study, we found that MGF mRNA expression of growth plate chondrocytes was upregulated in response to mechanical stimuli.
  8. 08LabIn vitro (cells)Mechanism

    In growth plate chondrocytes, MGF promoted YAP activation through RhoA GTPase-mediated cytoskeleton reorganization, and RhoA inhibition with C3 toxin abrogated it.

    In plain wordsIn growth plate cells in a dish, MGF activated YAP through RhoA, and blocking RhoA stopped this.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableRhoA-mediated YAP activation
    Study

    n: not reported in source

    growth plate chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, MGF promoted YAP activation through RhoA GTPase mediated cytoskeleton reorganization, RhoA inhibition using C3 toxin abrogated MGF induced YAP activation.
    1 context sentence
    Summary · context
    In the present study, we found that MGF mRNA expression of growth plate chondrocytes was upregulated in response to mechanical stimuli.
  9. 09LabIn vitro (cells)Mechanism

    In growth plate chondrocytes, MGF promoted focal adhesion formation.

    In plain wordsIn growth plate cells in a dish, MGF increased the formation of cell attachment sites.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseFocal adhesion formation
    Study

    n: not reported in source

    growth plate chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, we found that MGF promoted focal adhesion(FA) formation and knockdown of YAP with YAP siRNA partially suppressed the activation of FA kinase, implying that YAP is associated with FA formation.
    1 context sentence
    Summary · context
    In the present study, we found that MGF mRNA expression of growth plate chondrocytes was upregulated in response to mechanical stimuli.
  10. 10LabIn vitro (cells)Mechanism

    In growth plate chondrocytes, knockdown of YAP with siRNA partially suppressed the activation of focal adhesion kinase in cells where MGF promoted focal adhesion formation.

    In plain wordsIn growth plate cells in a dish, switching off YAP partly reduced the activation of a cell attachment enzyme that MGF affected.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableFocal adhesion kinase activation after YAP knockdown
    Study

    n: not reported in source

    growth plate chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, we found that MGF promoted focal adhesion(FA) formation and knockdown of YAP with YAP siRNA partially suppressed the activation of FA kinase, implying that YAP is associated with FA formation.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 11LabEndogenous levelIn vitro (cells)Mechanism

    In growth plate chondrocytes, MGF mRNA expression was upregulated in response to mechanical stimuli.

    In plain wordsIn growth plate cells in a dish, mechanical strain raised the body's own MGF mRNA levels.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF mRNA expression under mechanical stimuli
    Study

    n: not reported in source

    growth plate chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    In the present study, we found that MGF mRNA expression of growth plate chondrocytes was upregulated in response to mechanical stimuli.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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