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Study · Animal study (in vivo) · rabbit · 2018

4 results

Growth hormone-releasing peptide 6 prevents cutaneous hypertrophic scarring: early mechanistic data from a proteome study.

Fernández-Mayola M, Betancourt L, Molina-Kautzman A, Palomares S, Mendoza-Marí Y, Ugarte-Moreno D, Aguilera-Barreto A, Bermúdez-Álvarez Y, Besada V, González LJ, García-Ojalvo A, Mir-Benítez AJ, Urquiza-Rodríguez A, Berlanga-Acosta J

International wound journal21 Feb 2018Cited by 9 (Europe PMC)

PMID29464859 (opens in a new tab)PMCIDPMC7949743 (opens in a new tab)DOI10.1111/iwj.12895 (opens in a new tab)PepBankPUB-29464859
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, topical GHRP6 prevented hypertrophic scar onset compared with vehicle.

    In plain wordsIn rabbits, topical GHRP6 prevented hypertrophic scars compared with vehicle.

    Peptide
    GHRP-6
    Outcome
    DecreaseHypertrophic scar prevention
    Study

    rabbitn: not reported in source

    Hypertrophic scar model
    Comparator
    Vehicle
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · topical · day 1 to day 30 post-woundingAs given in this study (rabbit).

    Source sentences

    Summary
    GHRP6 prevented the onset of HTS without the untoward reactions induced by the first-line treatment triamcinolone acetonide (TA)
    2 context sentences
    Summary · context
    In the prevention approach, the wounds were assigned to topically receive GHRP6, triamcinolone acetonide (TA), or vehicle (1% sodium carboxy methylcellulose [CMC]) from day 1 to day 30 post-wounding.
    Summary · context
    Two independent sets of experiments addressing prevention and reversion effects were conducted on the classic HTS model in rabbits.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In rabbits, GHRP6 prevented hypertrophic scars without the untoward reactions induced by triamcinolone acetonide.

    In plain wordsIn rabbits, GHRP6 did not produce the unwanted reactions that triamcinolone acetonide produced.

    Peptide
    GHRP-6
    Outcome
    DecreaseUntoward reactions
    Study

    rabbitn: not reported in source

    Hypertrophic scar model
    Comparator
    Triamcinolone acetonide
    Outcome group
    Adverse events · Skin and wound
    Studied dose
    Dose not stated · topical · day 1 to day 30 post-woundingAs given in this study (rabbit).

    Source sentences

    Summary
    GHRP6 prevented the onset of HTS without the untoward reactions induced by the first-line treatment triamcinolone acetonide (TA)
    2 context sentences
    Summary · context
    In the prevention approach, the wounds were assigned to topically receive GHRP6, triamcinolone acetonide (TA), or vehicle (1% sodium carboxy methylcellulose [CMC]) from day 1 to day 30 post-wounding.
    Summary · context
    Two independent sets of experiments addressing prevention and reversion effects were conducted on the classic HTS model in rabbits.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits, GHRP6 did not significantly reverse mature hypertrophic scars compared with sterile saline.

    In plain wordsIn rabbits, GHRP6 did not significantly reverse mature scars compared with sterile saline.

    Peptide
    GHRP-6
    Outcome
    No significant changeReversal of mature hypertrophic scars
    Study

    rabbitn: not reported in source

    Hypertrophic scar model
    Comparator
    Sterile saline
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · infiltration · 4 consecutive weeksAs given in this study (rabbit).

    Source sentences

    Summary
    GHRP6 prevented the onset of HTS without the untoward reactions induced by the first-line treatment triamcinolone acetonide (TA); however, it failed to significantly reverse mature HTS.
    2 context sentences
    Summary · context
    The reversion scheme was based on the infiltration of either GHRP6 or sterile saline in mature HTS for 4 consecutive weeks.
    Summary · context
    Two independent sets of experiments addressing prevention and reversion effects were conducted on the classic HTS model in rabbits.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rabbits, preliminary proteomics linked GHRP6's scar prevention to pathways involving lipid metabolism, cytoskeleton, epidermal differentiation, and extracellular matrix dynamics.

    In plain wordsIn rabbits, preliminary protein analysis linked GHRP6's scar prevention to several cellular pathways.

    Peptide
    GHRP-6
    Outcome
    Direction not reportedProteomic pathways associated with fibrosis prevention
    Study

    rabbitn: not reported in source

    Hypertrophic scar model
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The preliminary proteomic study suggests that the anti-fibrotic preventing effect exerted by GHRP6 depends on different pathways involved in lipid metabolism, cytoskeleton arrangements, epidermal cells' differentiation, and ECM dynamics.
    2 context sentences
    Summary · context
    Tissue samples were collected for proteomics after 1 hour of HTS induction and treatment with either GHRP6 or vehicle.
    Summary · context
    Two independent sets of experiments addressing prevention and reversion effects were conducted on the classic HTS model in rabbits.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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