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Study · Animal study (in vivo) · mouse · 2018

5 results

Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice.

Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y

American journal of physiology. Heart and circulatory physiology16 Feb 2018Cited by 34 (Europe PMC)

PMID29451816 (opens in a new tab)PMCIDPMC6032086 (opens in a new tab)DOI10.1152/ajpheart.00718.2017 (opens in a new tab)PepBankPUB-29451816
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged hyperlipidemic mice, aortic calcification progressed similarly with teriparatide and PBS vehicle.

    In plain wordsIn mice, aortic calcification progressed similarly with lower-dose teriparatide and vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeAortic calcification progression at lower dose
    Study

    micen: not reported in source

    Aged female apolipoprotein E-deficient mice with aortic calcification
    Comparator
    PBS vehicle
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    40 µg/kg daily · injection · 4.5 weeksAs given in this study (mice).

    Source sentences

    Summary
    In both cohorts, aortic calcification detected by microCT progressed similarly in all groups.
    2 context sentences
    Summary · context
    Female apolipoprotein E-deficient mice were aged for over 1 yr to induce aortic calcification, treated for 4.5 wk with daily injections of control vehicle (PBS), 40 µg/kg teriparatide (PTH40), or 400 µg/kg teriparatide (PTH400), and assayed for aortic calcification by microcomputed tomography (micro…
    Summary · context
    In a followup cohort, aged female apolipoprotein E-deficient mice were treated with PBS or PTH400 and assayed for aortic calcification by serial microCT and micropositron emission tomography.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aged hyperlipidemic mice, aortic calcification progressed similarly with teriparatide and PBS vehicle in both cohorts.

    In plain wordsIn mice, aortic calcification progressed similarly with higher-dose teriparatide and vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeAortic calcification progression at higher dose
    Study

    micen: not reported in source

    Aged female apolipoprotein E-deficient mice with aortic calcification
    Comparator
    PBS vehicle
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    400 µg/kg daily · injection · 4.5 weeksAs given in this study (mice).

    Source sentences

    Summary
    In both cohorts, aortic calcification detected by microCT progressed similarly in all groups.
    2 context sentences
    Summary · context
    Female apolipoprotein E-deficient mice were aged for over 1 yr to induce aortic calcification, treated for 4.5 wk with daily injections of control vehicle (PBS), 40 µg/kg teriparatide (PTH40), or 400 µg/kg teriparatide (PTH400), and assayed for aortic calcification by microcomputed tomography (micro…
    Summary · context
    In a followup cohort, aged female apolipoprotein E-deficient mice were treated with PBS or PTH400 and assayed for aortic calcification by serial microCT and micropositron emission tomography.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aged hyperlipidemic mice, aortic fluoride tracer incorporation decreased during teriparatide treatment.

    In plain wordsIn mice, aortic fluoride tracer uptake decreased during higher-dose teriparatide treatment.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseAortic fluoride tracer incorporation
    Study

    micen: not reported in source

    Aged female apolipoprotein E-deficient mice with aortic calcification
    Comparator
    Baseline
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    400 µg/kg daily · injection · 4.5 weeksAs given in this study (mice).

    Measurements

    Fluoride incorporation change
    −33%
    PTH400

    Source sentences

    Summary
    In contrast, 18F-NaF incorporation decreased in the PTH400-treated group (-33 ± 20%, P = 0.03).
    2 context sentences
    Summary · context
    Female apolipoprotein E-deficient mice were aged for over 1 yr to induce aortic calcification, treated for 4.5 wk with daily injections of control vehicle (PBS), 40 µg/kg teriparatide (PTH40), or 400 µg/kg teriparatide (PTH400), and assayed for aortic calcification by microcomputed tomography (micro…
    Summary · context
    In a followup cohort, aged female apolipoprotein E-deficient mice were treated with PBS or PTH400 and assayed for aortic calcification by serial microCT and micropositron emission tomography.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In aged hyperlipidemic mice, teriparatide reduced the mineral surface area index versus PBS vehicle.

    In plain wordsIn mice, higher-dose teriparatide reduced mineral surface area compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseMineral surface area index
    Study

    micen: not reported in source

    Aged female apolipoprotein E-deficient mice with aortic calcification
    Comparator
    PBS vehicle
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    400 µg/kg daily · injection · 4.5 weeksAs given in this study (mice).

    Source sentences

    Summary
    Quantitative histochemical analysis by Alizarin red staining revealed a lower mineral surface area index in the PTH400-treated group compared with the PBS-treated group ( P = 0.04).
    2 context sentences
    Summary · context
    Female apolipoprotein E-deficient mice were aged for over 1 yr to induce aortic calcification, treated for 4.5 wk with daily injections of control vehicle (PBS), 40 µg/kg teriparatide (PTH40), or 400 µg/kg teriparatide (PTH400), and assayed for aortic calcification by microcomputed tomography (micro…
    Summary · context
    In a followup cohort, aged female apolipoprotein E-deficient mice were treated with PBS or PTH400 and assayed for aortic calcification by serial microCT and micropositron emission tomography.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In aged hyperlipidemic mice, teriparatide increased left ventricular myocardial collagen deposition versus PBS vehicle.

    In plain wordsIn mice, higher-dose teriparatide increased heart muscle collagen deposition compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseLeft ventricular collagen deposition
    Study

    micen: not reported in source

    Aged female apolipoprotein E-deficient mice with aortic calcification
    Comparator
    PBS vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    400 µg/kg daily · injection · 4.5 weeksAs given in this study (mice).

    Measurements

    Collagen deposition
    2.1%
    PTH400
    Collagen deposition
    0.5%
    control

    Source sentences

    Summary
    Furthermore, Masson trichrome staining showed a significant increase in collagen deposition in the left ventricular myocardium of mice that received PTH400 [2.1 ± 0.6% vs. control mice (0.5 ± 0.1%), P = 0.02].
    2 context sentences
    Summary · context
    Female apolipoprotein E-deficient mice were aged for over 1 yr to induce aortic calcification, treated for 4.5 wk with daily injections of control vehicle (PBS), 40 µg/kg teriparatide (PTH40), or 400 µg/kg teriparatide (PTH400), and assayed for aortic calcification by microcomputed tomography (micro…
    Summary · context
    In a followup cohort, aged female apolipoprotein E-deficient mice were treated with PBS or PTH400 and assayed for aortic calcification by serial microCT and micropositron emission tomography.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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Terms as the source lists them.

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