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Study · In vitro (cells) · 2018

9 results

ERK1/2 and Akt phosphorylation were essential for MGF E peptide regulating cell morphology and mobility but not proangiogenic capacity of BMSCs under severe hypoxia.

Sha Y, Yang L, Lv Y

Cell biochemistry and function13 Feb 2018Cited by 5 (Europe PMC)

PMID29441602 (opens in a new tab)DOI10.1002/cbf.3327 (opens in a new tab)PepBankPUB-29441602
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In BMSCs under severe hypoxia, MGF E peptide restored cell morphology (cell contraction, reduced cell area and roundness).

    In plain wordsIn stem cells in a dish under low oxygen, MGF E peptide restored normal cell shape.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCell contraction, area and roundness under hypoxia
    Study

    n: not reported in source

    BMSCs under CoCl2-simulated severe hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Fortunately, MGF E peptide could restore all abovementioned indexes except RhoA expression.
    2 context sentences
    Summary · context
    It was demonstrated that severe hypoxia (500-μM CoCl2 ) significantly caused cell contraction and reduced cell area, roundness, adhesion, and migration of BMSCs.
    Summary · context
    In this study, CoCl2 was used to simulate severe hypoxia and the effects of mechano-growth factor (MGF) E peptide on the morphology, adhesion, migration, and proangiogenic capacity of BMSCs under hypoxia were measured.
  2. 02LabIn vitro (cells)Efficacy outcome

    In BMSCs under severe hypoxia, MGF E peptide improved the decline of cell adhesion.

    In plain wordsIn stem cells in a dish under low oxygen, MGF E peptide improved cell attachment.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseBMSC adhesion under hypoxia
    Study

    n: not reported in source

    BMSCs under CoCl2-simulated severe hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This study proved that mechano-growth factor E (MGF E) peptide could improve the severe hypoxia-induced cell contraction and decline of cell adhesion and migration of BMSCs.
    1 context sentence
    Summary · context
    In this study, CoCl2 was used to simulate severe hypoxia and the effects of mechano-growth factor (MGF) E peptide on the morphology, adhesion, migration, and proangiogenic capacity of BMSCs under hypoxia were measured.
  3. 03LabIn vitro (cells)Efficacy outcome

    In BMSCs under severe hypoxia, MGF E peptide improved the decline of cell migration.

    In plain wordsIn stem cells in a dish under low oxygen, MGF E peptide improved cell movement.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseBMSC migration under hypoxia
    Study

    n: not reported in source

    BMSCs under CoCl2-simulated severe hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This study proved that mechano-growth factor E (MGF E) peptide could improve the severe hypoxia-induced cell contraction and decline of cell adhesion and migration of BMSCs.
    1 context sentence
    Summary · context
    In this study, CoCl2 was used to simulate severe hypoxia and the effects of mechano-growth factor (MGF) E peptide on the morphology, adhesion, migration, and proangiogenic capacity of BMSCs under hypoxia were measured.
  4. 04LabIn vitro (cells)Mechanism

    In BMSCs under severe hypoxia, MGF E peptide restored the inhibited expression of p-RhoA and the mobility-relevant proteins integrin β1, p-FAK and fibronectin.

    In plain wordsIn stem cells in a dish under low oxygen, MGF E peptide restored levels of proteins linked to cell movement.

    Peptide
    MGF / PEG-MGF
    Outcome
    Increasep-RhoA, integrin β1, p-FAK and fibronectin expression under hypoxia
    Study

    n: not reported in source

    BMSCs under CoCl2-simulated severe hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Fortunately, MGF E peptide could restore all abovementioned indexes except RhoA expression.
    2 context sentences
    Summary · context
    RhoA and ROCK1 expression levels were upregulated by severe hypoxia, but p-RhoA and mobility-relevant protein (integrin β1, p-FAK and fibronectin) expression levels in BMSCs were inhibited.
    Summary · context
    In this study, CoCl2 was used to simulate severe hypoxia and the effects of mechano-growth factor (MGF) E peptide on the morphology, adhesion, migration, and proangiogenic capacity of BMSCs under hypoxia were measured.
  5. 05LabIn vitro (cells)Mechanism

    In BMSCs under severe hypoxia, MGF E peptide did not restore the upregulated RhoA expression.

    In plain wordsIn stem cells in a dish under low oxygen, MGF E peptide did not bring RhoA levels back to normal.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeRhoA expression under hypoxia
    Study

    n: not reported in source

    BMSCs under CoCl2-simulated severe hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Fortunately, MGF E peptide could restore all abovementioned indexes except RhoA expression.
    2 context sentences
    Summary · context
    RhoA and ROCK1 expression levels were upregulated by severe hypoxia, but p-RhoA and mobility-relevant protein (integrin β1, p-FAK and fibronectin) expression levels in BMSCs were inhibited.
    Summary · context
    In this study, CoCl2 was used to simulate severe hypoxia and the effects of mechano-growth factor (MGF) E peptide on the morphology, adhesion, migration, and proangiogenic capacity of BMSCs under hypoxia were measured.
  6. 06LabIn vitro (cells)Mechanism

    In BMSCs under severe hypoxia, the MEK-ERK1/2 pathway was involved in MGF E peptide regulating cell morphology, mobility and relevant proteins (except p-FAK).

    In plain wordsIn stem cells in a dish, MGF E peptide acted on cell shape and movement partly through the MEK-ERK1/2 pathway.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableMEK-ERK1/2 pathway involvement
    Study

    n: not reported in source

    BMSCs under CoCl2-simulated severe hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MEK-ERK1/2 pathway was involved in MGF E peptide regulating cell morphological changes, mobility, and relevant proteins (except p-FAK).
    1 context sentence
    Summary · context
    In this study, CoCl2 was used to simulate severe hypoxia and the effects of mechano-growth factor (MGF) E peptide on the morphology, adhesion, migration, and proangiogenic capacity of BMSCs under hypoxia were measured.
  7. 07LabIn vitro (cells)Mechanism

    In BMSCs under severe hypoxia, the PI3K-Akt pathway was involved in MGF E peptide regulating cell area, mobility and relevant proteins.

    In plain wordsIn stem cells in a dish, MGF E peptide acted on cell area and movement partly through the PI3K-Akt pathway.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicablePI3K-Akt pathway involvement
    Study

    n: not reported in source

    BMSCs under CoCl2-simulated severe hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PI3K-Akt pathway was involved in MGF E peptide regulating cell area, mobility, and relevant proteins.
    1 context sentence
    Summary · context
    In this study, CoCl2 was used to simulate severe hypoxia and the effects of mechano-growth factor (MGF) E peptide on the morphology, adhesion, migration, and proangiogenic capacity of BMSCs under hypoxia were measured.
  8. 08LabIn vitro (cells)Efficacy outcome

    In BMSCs under severe hypoxia, MGF E peptide showed an adverse effect on the expression level of vascular endothelial growth factor α.

    In plain wordsIn stem cells in a dish under low oxygen, MGF E peptide had an adverse effect on VEGFα expression.

    Peptide
    MGF / PEG-MGF
    Outcome
    Direction not reportedVEGFα expression under hypoxia
    Study

    n: not reported in source

    BMSCs under CoCl2-simulated severe hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    it was confirmed that MGF E peptide showed an adverse effect on the expression level of vascular endothelial growth factor α in BMSCs under severe hypoxia
    1 context sentence
    Summary · context
    In this study, CoCl2 was used to simulate severe hypoxia and the effects of mechano-growth factor (MGF) E peptide on the morphology, adhesion, migration, and proangiogenic capacity of BMSCs under hypoxia were measured.
  9. 09LabIn vitro (cells)Efficacy outcome

    In BMSCs under severe hypoxia, MGF E peptide accelerated cell proliferation.

    In plain wordsIn stem cells in a dish under low oxygen, MGF E peptide sped up cell multiplication.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseBMSC proliferation under hypoxia
    Study

    n: not reported in source

    BMSCs under CoCl2-simulated severe hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but could make up for this deficiency through accelerating cell proliferation.
    1 context sentence
    Summary · context
    In this study, CoCl2 was used to simulate severe hypoxia and the effects of mechano-growth factor (MGF) E peptide on the morphology, adhesion, migration, and proangiogenic capacity of BMSCs under hypoxia were measured.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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