Skip to content

Study · Animal study (in vivo) · mouse · 2018

13 results

Expression level of 12-amino acid triggering receptor on myeloid cells-like transcript 1 derived peptide alleviates lipopolysaccharide-induced acute lung injury in mice.

Shi R, Zhang J, Peng Z, Yuan S, Gao S, Chen L, Yuan Y

International journal of molecular medicine30 Jan 2018Cited by 9 (Europe PMC)

PMID29393375 (opens in a new tab)DOI10.3892/ijmm.2018.3443 (opens in a new tab)PepBankPUB-29393375
Source linkPubMedAsk about this study
Jump to 13 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced lung injury, LR12 significantly reduced pathohistological injury versus scramble.

    In plain wordsIn mice, LR12 significantly reduced lung tissue injury versus scramble.

    Peptide
    Nangibotide
    Outcome
    DecreasePathohistological lung injury
    Study

    mousen: not reported in source

    Male C57BL/6 mice with LPS-induced acute lung injury
    Comparator
    LPS + scramble
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    LPS‑induced pathohistological injury, edema and neutrophil infiltration were significantly alleviated by TREM‑1 inhibitor, LR12.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group. Normal saline (NS) or LPS was administrated by intratracheal instillation, and NS, LR12 or LR12 scramble was administered intraperitoneally 30 min later.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced lung injury, LR12 significantly reduced edema versus scramble.

    In plain wordsIn mice, LR12 significantly reduced lung edema versus scramble.

    Peptide
    Nangibotide
    Outcome
    DecreaseLung edema
    Study

    mousen: not reported in source

    Male C57BL/6 mice with LPS-induced acute lung injury
    Comparator
    LPS + scramble
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    LPS‑induced pathohistological injury, edema and neutrophil infiltration were significantly alleviated by TREM‑1 inhibitor, LR12.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group. Normal saline (NS) or LPS was administrated by intratracheal instillation, and NS, LR12 or LR12 scramble was administered intraperitoneally 30 min later.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced lung injury, LR12 significantly reduced neutrophil infiltration versus scramble.

    In plain wordsIn mice, LR12 significantly reduced lung neutrophil infiltration versus scramble.

    Peptide
    Nangibotide
    Outcome
    DecreaseNeutrophil infiltration
    Study

    mousen: not reported in source

    Male C57BL/6 mice with LPS-induced acute lung injury
    Comparator
    LPS + scramble
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    LPS‑induced pathohistological injury, edema and neutrophil infiltration were significantly alleviated by TREM‑1 inhibitor, LR12.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group. Normal saline (NS) or LPS was administrated by intratracheal instillation, and NS, LR12 or LR12 scramble was administered intraperitoneally 30 min later.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced lung injury, LR12 significantly reduced IL-6 versus scramble.

    In plain wordsIn mice, LR12 significantly reduced IL-6 versus scramble.

    Peptide
    Nangibotide
    Outcome
    DecreaseIL-6
    Study

    mousen: not reported in source

    Male C57BL/6 mice with LPS-induced acute lung injury
    Comparator
    LPS + scramble
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The proinflammatory cytokines [interleukin (IL)‑6, IL‑1β, tumor necrosis factor‑α] and chemokines (keratinocyte chemokine and monocyte chemoattractant protein‑1) were significantly reduced, whereas the anti‑inflammatory cytokines, IL‑10 were significantly increased by LR12.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group. Normal saline (NS) or LPS was administrated by intratracheal instillation, and NS, LR12 or LR12 scramble was administered intraperitoneally 30 min later.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced lung injury, LR12 significantly reduced IL-1β versus scramble.

    In plain wordsIn mice, LR12 significantly reduced IL-1β versus scramble.

    Peptide
    Nangibotide
    Outcome
    DecreaseIL-1β
    Study

    mousen: not reported in source

    Male C57BL/6 mice with LPS-induced acute lung injury
    Comparator
    LPS + scramble
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The proinflammatory cytokines [interleukin (IL)‑6, IL‑1β, tumor necrosis factor‑α] and chemokines (keratinocyte chemokine and monocyte chemoattractant protein‑1) were significantly reduced, whereas the anti‑inflammatory cytokines, IL‑10 were significantly increased by LR12.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group. Normal saline (NS) or LPS was administrated by intratracheal instillation, and NS, LR12 or LR12 scramble was administered intraperitoneally 30 min later.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced lung injury, LR12 significantly reduced tumor necrosis factor-α versus scramble.

    In plain wordsIn mice, LR12 significantly reduced tumor necrosis factor-α versus scramble.

    Peptide
    Nangibotide
    Outcome
    DecreaseTumor necrosis factor-α
    Study

    mousen: not reported in source

    Male C57BL/6 mice with LPS-induced acute lung injury
    Comparator
    LPS + scramble
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The proinflammatory cytokines [interleukin (IL)‑6, IL‑1β, tumor necrosis factor‑α] and chemokines (keratinocyte chemokine and monocyte chemoattractant protein‑1) were significantly reduced, whereas the anti‑inflammatory cytokines, IL‑10 were significantly increased by LR12.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group. Normal saline (NS) or LPS was administrated by intratracheal instillation, and NS, LR12 or LR12 scramble was administered intraperitoneally 30 min later.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced lung injury, LR12 significantly reduced keratinocyte chemokine versus scramble.

    In plain wordsIn mice, LR12 significantly reduced keratinocyte chemokine versus scramble.

    Peptide
    Nangibotide
    Outcome
    DecreaseKeratinocyte chemokine
    Study

    mousen: not reported in source

    Male C57BL/6 mice with LPS-induced acute lung injury
    Comparator
    LPS + scramble
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The proinflammatory cytokines [interleukin (IL)‑6, IL‑1β, tumor necrosis factor‑α] and chemokines (keratinocyte chemokine and monocyte chemoattractant protein‑1) were significantly reduced, whereas the anti‑inflammatory cytokines, IL‑10 were significantly increased by LR12.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group. Normal saline (NS) or LPS was administrated by intratracheal instillation, and NS, LR12 or LR12 scramble was administered intraperitoneally 30 min later.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced lung injury, LR12 significantly reduced monocyte chemoattractant protein-1 versus scramble.

    In plain wordsIn mice, LR12 significantly reduced monocyte chemoattractant protein-1 versus scramble.

    Peptide
    Nangibotide
    Outcome
    DecreaseMonocyte chemoattractant protein-1
    Study

    mousen: not reported in source

    Male C57BL/6 mice with LPS-induced acute lung injury
    Comparator
    LPS + scramble
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The proinflammatory cytokines [interleukin (IL)‑6, IL‑1β, tumor necrosis factor‑α] and chemokines (keratinocyte chemokine and monocyte chemoattractant protein‑1) were significantly reduced, whereas the anti‑inflammatory cytokines, IL‑10 were significantly increased by LR12.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group. Normal saline (NS) or LPS was administrated by intratracheal instillation, and NS, LR12 or LR12 scramble was administered intraperitoneally 30 min later.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced lung injury, LR12 significantly increased IL-10 versus scramble.

    In plain wordsIn mice, LR12 significantly increased IL-10 versus scramble.

    Peptide
    Nangibotide
    Outcome
    IncreaseIL-10
    Study

    mousen: not reported in source

    Male C57BL/6 mice with LPS-induced acute lung injury
    Comparator
    LPS + scramble
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The proinflammatory cytokines [interleukin (IL)‑6, IL‑1β, tumor necrosis factor‑α] and chemokines (keratinocyte chemokine and monocyte chemoattractant protein‑1) were significantly reduced, whereas the anti‑inflammatory cytokines, IL‑10 were significantly increased by LR12.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group. Normal saline (NS) or LPS was administrated by intratracheal instillation, and NS, LR12 or LR12 scramble was administered intraperitoneally 30 min later.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced lung injury, LR12 significantly decreased nuclear p65 expression versus scramble.

    In plain wordsIn mice, LR12 significantly decreased nuclear p65 expression versus scramble.

    Peptide
    Nangibotide
    Outcome
    DecreaseNuclear p65 expression
    Study

    mousen: not reported in source

    Male C57BL/6 mice with LPS-induced acute lung injury
    Comparator
    LPS + scramble
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    LR12 was identified to significantly decrease p65 expression levels in the nucleus and inhibit the activity of NF‑κB.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group. Normal saline (NS) or LPS was administrated by intratracheal instillation, and NS, LR12 or LR12 scramble was administered intraperitoneally 30 min later.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced lung injury, LR12 inhibited NF-κB activity versus scramble.

    In plain wordsIn mice, LR12 inhibited NF-κB activity versus scramble.

    Peptide
    Nangibotide
    Outcome
    DecreaseNF-κB activity
    Study

    mousen: not reported in source

    Male C57BL/6 mice with LPS-induced acute lung injury
    Comparator
    LPS + scramble
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    LR12 was identified to significantly decrease p65 expression levels in the nucleus and inhibit the activity of NF‑κB.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group. Normal saline (NS) or LPS was administrated by intratracheal instillation, and NS, LR12 or LR12 scramble was administered intraperitoneally 30 min later.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced lung injury, LR12 reduced TREM-1 expression versus scramble.

    In plain wordsIn mice, LR12 reduced TREM-1 expression versus scramble.

    Peptide
    Nangibotide
    Outcome
    DecreaseTREM-1 expression
    Study

    mousen: not reported in source

    Male C57BL/6 mice with LPS-induced acute lung injury
    Comparator
    LPS + scramble
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, LR12 alleviated LPS‑induced ALI by reducing the expression of TREM‑1, increasing the release of soluble TREM‑1 and inhibiting activation of the NF-κB signaling pathway.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group. Normal saline (NS) or LPS was administrated by intratracheal instillation, and NS, LR12 or LR12 scramble was administered intraperitoneally 30 min later.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced lung injury, LR12 increased soluble TREM-1 release versus scramble.

    In plain wordsIn mice, LR12 increased soluble TREM-1 release versus scramble.

    Peptide
    Nangibotide
    Outcome
    IncreaseSoluble TREM-1 release
    Study

    mousen: not reported in source

    Male C57BL/6 mice with LPS-induced acute lung injury
    Comparator
    LPS + scramble
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, LR12 alleviated LPS‑induced ALI by reducing the expression of TREM‑1, increasing the release of soluble TREM‑1 and inhibiting activation of the NF-κB signaling pathway.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were randomly assigned to three groups as follows: Sham group, LPS + scramble group and LPS + LR12 group. Normal saline (NS) or LPS was administrated by intratracheal instillation, and NS, LR12 or LR12 scramble was administered intraperitoneally 30 min later.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.