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Study · Animal study (in vivo) · mouse · 2018

4 results

Targeted endothelial gene deletion of triggering receptor expressed on myeloid cells-1 protects mice during septic shock.

Jolly L, Carrasco K, Derive M, Lemarié J, Boufenzer A, Gibot S

Cardiovascular research1 May 2018Cited by 42 (Europe PMC)

PMID29361046 (opens in a new tab)DOI10.1093/cvr/cvy018 (opens in a new tab)PepBankPUB-29361046
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, LR12 prevented impaired vascular reactivity associated with TREM-1 engagement.

    In plain wordsIn mice, LR12 prevented impaired blood vessel reactivity associated with TREM-1 engagement.

    Peptide
    Nangibotide
    Outcome
    DecreaseImpaired vascular reactivity
    Study

    mousen: not reported in source

    Vascular TREM-1 engagement
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The pharmacological inhibition of TREM-1 (using the synthetic inhibitory peptide LR12) prevented these disorders both in vitro and in vivo.
    1 context sentence
    Summary · context
    We next observed that TREM-1 engagement impaired mouse vascular reactivity and promoted vascular inflammation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, LR12 prevented vascular inflammation associated with TREM-1 engagement.

    In plain wordsIn mice, LR12 prevented blood vessel inflammation associated with TREM-1 engagement.

    Peptide
    Nangibotide
    Outcome
    DecreaseVascular inflammation
    Study

    mousen: not reported in source

    Vascular TREM-1 engagement
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The pharmacological inhibition of TREM-1 (using the synthetic inhibitory peptide LR12) prevented these disorders both in vitro and in vivo.
    1 context sentence
    Summary · context
    We next observed that TREM-1 engagement impaired mouse vascular reactivity and promoted vascular inflammation.
  3. 03LabOther designEfficacy outcome

    In vitro, LR12 prevented vascular dysfunction associated with TREM-1 engagement.

    In plain wordsIn lab tests, LR12 prevented vascular dysfunction associated with TREM-1 engagement.

    Peptide
    Nangibotide
    Outcome
    DecreaseImpaired vascular reactivity
    Study

    n: not reported in source

    In vitro vascular experiments
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The pharmacological inhibition of TREM-1 (using the synthetic inhibitory peptide LR12) prevented these disorders both in vitro and in vivo.
    1 context sentence
    Summary · context
    We next observed that TREM-1 engagement impaired mouse vascular reactivity and promoted vascular inflammation.
  4. 04LabOther designEfficacy outcome

    In vitro, LR12 prevented vascular inflammation associated with TREM-1 engagement.

    In plain wordsIn lab tests, LR12 prevented vascular inflammation associated with TREM-1 engagement.

    Peptide
    Nangibotide
    Outcome
    DecreaseVascular inflammation
    Study

    n: not reported in source

    In vitro vascular experiments
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The pharmacological inhibition of TREM-1 (using the synthetic inhibitory peptide LR12) prevented these disorders both in vitro and in vivo.
    1 context sentence
    Summary · context
    We next observed that TREM-1 engagement impaired mouse vascular reactivity and promoted vascular inflammation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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